Top Tweets for #Capsids
@yusufhameed @SP28947316 BP keep waiting for $SGMOโs STAC-BBB #capsid to hit the clinic (first shot likely in #Prion later this year).
The NHP data look strong, arguably better than several competitors, but the only proof that matters is human data. If itโs well-tolerated in patients, itโs a no-brainer.
@JoshInvestValue Both are in-house-developed ( $SGMO ) but very different #AAV #capsids:
๐น For #pain โ ST-503 uses #capsid STAC-102 or STAC-103 for #intrathecal delivery.
๐น For #prion and #tauopathy programs - STAC-BBB, an intravenously administered BBB-crossing capsid.
@SchoolyardPS7 In other words; for the success of the #Capsids, it's totally unimportant if you trust @SangamoTx's management.
The question regarding Capsid success is: Do you trust the management at @EliLillyandCo, @Roche/@genentech, and @AstellasUS?
$SGMO $LLY $RHHBY $ALPMY
@Franca_ole @yusufhameed #Prevail as in "Prevail Therapeutics"? Isn't the $LLY subsidiary not shopping for #capsids right now?
Is your post a hidden clue as to who the next $SGMO partner might be?
https://t.co/nGn3n1Ty56
@SchoolyardPS7 @BiotechAnalysst @bduclaux @TechMatter5 @Jefferies There will be recurring revenue at least 10%
$400M would extend $SGMO cash runway until 2029.
How are you then evaluating #HemA, #Pain, #Prion, #Alzheimer's #capsids #MINT #Treg etc ..
@yusufhameed @SangamoTx @adamfeuerstein @megtirrell @jimcramer @cvpayne @US_FDA @pfizer @Roche @TakedaPharma Nice list .. I would like to add that $LLY/Prevail have the right of first refusal on some of $SGMO's #Capsids
Also I am missing the #CAR #Tregs on that list ๐
https://t.co/w24TKEbBTb
@yusufhameed @NEJM @SangamoTx You are raising good questions and indeed $SGMO #ZiFi based #celltherapy has shown NO longterm ADRs like cancer. I think when their #Capsids and ZiFi suppressors show good safety profile in humans #Pain & #Prion 25/26 sky is the limit no need for a takeover.
@bill_us you also could think of applications where you want $SGMO #capsids for a different than IV route ... #GeneTherapy is one time injection ... keep in mind $BIIB / $IONS planning to deliver their anti #Tau #ASO via cerebrospinal fluid (CSF) injection every 12 or 24 weeks.
@BehaviorFin @snicobio @monaco_biotech Guess what $LLY 100% subsidiary company #Prevail Therapeutics is testing $SGMO #capsids for #CNS delivery since last summer: https://t.co/kcrvVUpyzz
@RNAiAnalyst all fair points!: but look what kind of license deals $VYGR got for their compared to $SGMO less efficient #capsids ... https://t.co/y90fn20ihG
@BiotechAnalysst @GamalielBaer und I add a 50% PoS for #Treg deal and an therefore an upside value >17.50$ $SGMO by Plattform @RBC means the #Capsids I guess not even the Modular Integrase (MINT) platform raveled at #ASGCT2024. @SangamoTx https://t.co/wliwSoO9cx
We are thrilled to reveal @SangamoTxโs Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: https://t.co/zXcGGr3VJo [1/10]
![f_fauser's tweet photo. We are thrilled to reveal @SangamoTxโs Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: https://t.co/zXcGGr3VJo [1/10] https://t.co/N20Tezcy2a](https://pbs.twimg.com/media/GNI0PewaUAEdUdf.png)
These #capsids abele to cross the #BBB in NHP optimized for #zincfinger proteins allowing numerous #genetherapy and #epegentic interventions in the #CNS https://t.co/hVLRFmmnsl
We are excited to announce our neurotropic AAV capsid that demonstrated industry-leading BBB penetration and brain transduction in primates following IV admin. Learn more here:https://t.co/ZSxwpc2P8p
@doepke_michel The $SGMO combination of #zincfinger with #neurotrophic #capsids and #intracranial injection should have a even more potent effect...
pyCapsid analyzes protein shell dynamics and mechanical units in high-resolution structures, especially virus #capsids, providing insights through collective vibrations and disassembly-associated regions. [co-authored by EVBC member @toniluqe] https://t.co/l1ZUkbnbjk #virustools
@BiotechAnalysst If I would be in $AZN shoes I would buy $SGMO shares - much bigger/better #genetherapy Pipeline including #Capsids for less $$$
Well, I am very very VERY happy to announce that I have been awarded an @arc_gov_au #FutureFellowship #FT23 to do some very cool things with #virus #capsids @Griffith_Uni @GRIDD_GU
@BiotechAnalysst @AppleHelix Indeed #Capsids need to be optimized for each desease. Educated guess: $SGMO Capsids $LLY is evaluating are given via intracerebral/spinal injections whereas due to safety reasons in highly infectious #Prion-desease the licend Capsids from $VYGR are more likely given systemically
Join the conversation tackling the greatest gene therapy manufacturing and analytical challenges.
https://t.co/rzwMRvgJOt #genetherapy #gene #vectors #viral #potencyassay #impurities #plasmids #comparability #analysis #control #manufacturing #chemistry #capsids #cmc #downstream
#HSV-1 #virus #capsids bind to nuclear pores and release viral #DNA through a portal in the capsid formed by a dodecamer of the #UL6 #protein.
See also our #textbook "#Allgemeine #Virologie" (2nd edition, Tobler, Ackermann Fraefel) ISBN: 978-3-8252-5630-2
@HauptVerlag @uzh_de
Researchers engineer family of adeno-associated #viralvectors that cross #bloodbrainbarrier in primate models, advancing efforts to develop #genetherapies for #neurologicaldiseases. https://t.co/SW14T3yH4o #AAVs #viralvector #AAV #AAV9 #viralcapsids #capsids #viruses #genetherapy
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