Friedrich Fauser

Genome Engineer | Early R&D Scientist @SangamoTx | Postdoc @JonikasLab, @CarnegiePlants & @PrincetonMolBio | PhD @PuchtaLab, @KITKarlsruhe | Tweets are my own

[Friedrich Fauser @f_fauser]

We are thrilled to reveal @SangamoTx‘s Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: https://t.co/zXcGGr3VJo [1/10]

[Sangamo Therapeutics @SangamoTx]

🧬🚀 We’ve made substantial progress in development of our modular integrase, or MINT, platform- a gene editing method that we believe will enable large-scale genome engineering. Our updated manuscript which showcases these advances is available on bioRxiv https://t.co/C0ARgcMXB1

[Friedrich Fauser @f_fauser]

Thrilled to share this update on bioRxiv:
https://t.co/Zzh5LBbBIu

>10x activity, T cell data & genome-wide specificity evaluation!

[Friedrich Fauser @f_fauser]

We are thrilled to reveal @SangamoTx‘s Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: https://t.co/zXcGGr3VJo [1/10]

[Martin Jonikas @JonikasLab]

We are excited to share 71,700 new #Chlamy mutants from the CLiP2 collection pre-publication! Nearly-saturating genome coverage.

Please note: new background strain, mating type, and antibiotic resistance.

Read: https://t.co/t0SUtH26rP
Search and order: https://t.co/4dGxCXXrmt

[Martin Jonikas @JonikasLab]

Excited to share our latest preprint!
Biogenesis, engineering and function of membranes in the CO2-fixing pyrenoid
https://t.co/NAxQmBXSky

[Friedrich Fauser @f_fauser]

Thanks @FremontFire for putting this Niles Canyon fire out quickly and @FremontPD for patrolling the neighborhood :)

[Friedrich Fauser @f_fauser]

@pituvilarnadal @NatureComms @Dinnenylab @JonikasLab Congrats Pep! Excited to see what comes next :)

[Josep Vilarrasa Blasi @pituvilarnadal]

After a mere blink in the cosmos -3 years as a preprint- our paper has found its home in @NatureComms . Thanks to all coauthors, the long supporting journey @Dinnenylab, and collaborators @JonikasLab and Michael Sussman. Oh, and by the way, I'm job hunting!!!

[Sangamo Therapeutics @SangamoTx]

One of our lead scientists, @wraithnot is presenting @FASEBorg about our exciting Modular Integrase (MINT) platform, a new approach to 🎯 integration of large 🧬 constructs into precise locations within the human genome. #genomicmedicine #MINTplatform

[Friedrich Fauser @f_fauser]

@Shanhe_PU @UWBotany @UWMadisonLS @UWMadison Congrats! :)

[Sebastian Arangundy Franklin @SArangundy]

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences https://t.co/SzeyxM68mL

[Jeff Miller @wraithnot]

Our #MINTplatform does not use #CRISPR, #ZincFinger or #TALeffector to 🎯 DNA. Instead, we directly reprogram Bxb1 integrase to go where we want in the human genome. The details are in our @bioRxiv paper: https://t.co/AxcZ5PYkHz

[Sangamo Therapeutics @SangamoTx]

We are thrilled to announce the publication of our manuscript detailing the development of our Modular Integrase (MINT) platform #MINTplatform is now live on @bioRxiv! https://t.co/macyMhbRNy @f_fauser @gdavis624 @arangundy @wraithnot

[Jeff Miller @wraithnot]

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences https://t.co/xjdxx7JWEh - our paper describing reprogrammed serine integrases is now on BioRxiv!

[Tom Ellis @ProfTomEllis]

Cool new preprint from Sangamo, engineering BxbI integrase to target native sites in the genome. Who needs landing pads now?

[Sergio Gutiérrez 👨‍🔬🦠🧬 @SaGutierrezz]

MINT platform reprograms Bxb1 integrase for precise genome editing. Achieving up to 35% efficiency, it integrates kilobase-sized constructs into specific genomic sites, including human TRAC and AAVS1 loci.🧬👨‍🔬✂️#GenomeEditing #SyntheticBiology #GeneTherapy https://t.co/9RjHc5LCmD

[Friedrich Fauser @f_fauser]

Now on bioRxiv:
Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences https://t.co/4TYHfeiOCK

Original Thread: https://t.co/XcZAufBhcp

[Friedrich Fauser @f_fauser]

We are thrilled to reveal @SangamoTx‘s Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: https://t.co/zXcGGr3VJo [1/10]

[Friedrich Fauser @f_fauser]

@SArangundy And here is the bioRxiv link:
https://t.co/XI5X11JyMf

Thanks to everyone who showed up at the #ASGCT2024 poster session. Didn't expect this to turn into ~5h of conversations :)

[Friedrich Fauser @f_fauser]

Please find Greg Davis (@gdavis264), Sebastian Arangundy (@Arangundy), or myself (Poster 1680, Friday) during #ASGCT2024 to talk science; or meet up with Jeff Miller (@wraithnot) during FASEB in Rome! Thanks to everyone who contributed to this project – this was fun 😊 [9/10]

[Friedrich Fauser @f_fauser]

Handle correction: @SArangundy

[Friedrich Fauser @f_fauser]

@mchilberg FASEB:
https://t.co/R7MkykVwtS

[Sangamo Therapeutics @SangamoTx]

Today at #ASGCT2024 is the platform presentation for our next-generation Modular Integrase (MINT) technology, engineered to enable large-scale genome editing. Learn how the MINT platform utilizes Bxb1, to integrate large sequences of 🧬 into the genome. https://t.co/Djj9h3pP9H

[Friedrich Fauser @f_fauser]

@jadafo @SangamoTx Thanks, Jason! Also thanks for all the support during this time!