Top Tweets for #CardioVascRes
What are Markers of arterial adventitial fibroblast?
PDGFRA🧐
DPEP1
3 fibroblast subsets
CD55+
LOX+
CXCL14+
CD55+ adventitial fibroblasts are enriched in thoracic aorta & carotid artery, but rare in other large arteries
@SluimerJudith #CardiovascRes 2023
https://t.co/oSLdTniPRv
PRMT5 methylates & stabilizes KLF4 protein▶️
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023 @ESC_Journ@ESC_Journals
https://t.co/qdDvKGrVEP
#SmoothMuscleCell #Atherosclerosis
SMC CCN2/CTGF KO creates a striking #Glycosaminoglycan-depositing & LDL-entrapping, pro-atherogenic phenotype😎◀️What is the cellular mechanism?🧐
What a crazy Fatty mouse Aorta!🤯
@_lassebs #CardiovascRes 2024 @ESC_Journals
https://t.co/cpTdp9liur
#SmoothMuscleCell MMP3 mediates #ArterialCalcification in mice+Vitamin D3 (How?🧐)
MMP3 is the only MMP upregulated in calcifying rat aortic SMCs (Pi/Ca2+)
Raul Guzman lab #CardiovascRes 2024
https://t.co/0WAQoyfty9
αSMA+ #SmoothMuscleCell-TRAP;Ldlr−/−;ApoB100/100🐭▶️SMC Translatome in #Atherosclerosis
Novel atherosclerosis proteins
Spink5
Atp1a4
Gm13293
Hs6st2
Itih4
Smim3
Pcdh11x
No EndMT trait detected
@Aarthi_Ravindra @OrdTiit @KaikkonenLab #CardiovascRes 2024
https://t.co/mvYe2JnDaG
Transcriptional driver ZBTB11 of #Cardiomyocyte degeneration (#Autophagy #Apoptosis) in PKP2 #ArrhythmogenicCardiomyopathy
Tomo-seq
RNAseq of 214 100-μm cryosections of👤LV wall
Epicardium-to-Endocardium🤠
#SpatialTranscriptomics
#CardiovascRes 2022
https://t.co/OXdvi0w5lN
Genetic (p16-3MR) vs Pharmacological (ABT263) #Senolysis in ApoE-/-🐭#Atherosclerosis
p16-3MR: No benefits
ABT263:⏬lesion👉senolyis+leukocyte depletion
Proliferating Mφ also p16+;SAβGal+
🧐#Senescence in situ?
Martin Bennett lab #CardiovascRes 2022
https://t.co/V63WKDVz9Q
Collagen IV-nanoparticle delivers PAD4i GSK484 to eroded atherosclerotic lesions with exposed basement membrane
⏫lesional #EndothelialCell coverage
⏬local NET
in🐭flow-mediated #SuperficialErosion
Dr. Jinjun Shi & Peter Libby labs #CardiovascRes 2021
https://t.co/p7lFBgFH4A
#Foxo1 mediates the inhibitory effect of JQ1, a #Bromodomain-containing protein (acetyl-lysine reader) inhibitor, on #SmoothMuscleCell proliferation
+Differential roles of BRD2/3/4 in proliferation🤓
Dr. Daniel Sedding lab #CardiovascRes 2021 @SeddingUni
https://t.co/5iusiVDKiq
Single-nuclei Transcriptomics human Lung
#COVID19 x7
IPF x6
Ctrl x12
COVID🫁
⏫Systemic venous+capillary #EndothelialCell
⏬general capillary EC
⏬Epi-Endo Notch, EC-stromal PDGF
⏫Stromal-EC PlxnA-Sema3A
@CarmelietLab #CardiovascRes 2022 @ESC_Journals
https://t.co/Jsvfwfbo3q
Partial #EndMT, marked by #Hypoxia-induced CD45, as a major cellular source for neointima formation
50% ECs in ligated artery are CD45+🤠
CD45 maintains this Partial status😈
Amazing!🤩
@Chura_rhythm @HYanagisawaLab #CardiovascRes 2022 @ESC_Journals
https://t.co/i3ewZKF8u0
Chromatin landscape dynamics of #SmoothMuscleCell in #Atherosclerosis🐭
Integrated scATACseq+scRNAseq+lineage tracing analysis reveals a protective role of ATF3 in atherogenic #Complement 3+ SMC
Dr. Ying Wang & Nicholas Leeper lab #CardiovascRes 2022
https://t.co/Qi2LC4HQX4
Oligoclonal expansion (Confetti lineage tracing) & single-cell transcriptional trajectory of a minor population of pre-existing Sca1+ arterial #SmoothMuscleCell in 🐭carotid injury & #Atherosclerosis
Dr. Helle Jørgensen lab #CardiovascRes 2022 @hfj22
https://t.co/97Z3KtxBS6
BMPR1A, a new signaling player in #PulmonaryArteryHypertension🤠
Postnatal #EndothelialCell BMPR1A KO->
⏬ID2->
⏫ZEB1-dependent TGFBR2 transcription & #EndMT
Dr. Suk Won Jin & Hyung J Chun labs #CardiovascRes 2022 @ESC_Journals @CVR_TomaszGuzik
https://t.co/A6I1iXljRo
#PaperAlert! Check out latest pub: “Chronically elevated branched chain amino acid levels are pro-arrhythmic” on #CardiovascRes
https://t.co/nc6FSc7uZC
Kudos to our @DigiMedBayern partners! @EPI_Helmholtz @HelmholtzMunich @dzhk_germany @DiabResearch @LMU_Uniklinikum @LMU_Muenchen
An antiplatelet response gene expression signature is associated with bleeding | #THIPubs #THIFellowship @JordanGales5 | @ESC_Journals #CardiovascRes https://t.co/fkGOSEElGT
#PaperAlert 🎊
recent @DigiMedBayern paper by @LarsMaeg: Organ-on-a-chip technology: a novel approach to investigate #cardiovascular diseases, #CardiovascRes. Congrats to the whole team! @TU_Muenchen @VascularTUM @dzhk_germany @karolinskainst @uppsalauni https://t.co/xX2ENdSjyw
Targeting the Hippo pathway in heart repair • #THIPubs @jmartinlab @ESC_Journals #CardiovascRes
https://t.co/RJBr2a6vDj
Recommendations for nomenclature and definition of cell products intended for human cardiovascular use • #THIPubs @dralourdeschac1 @CHM_RMR #DrEmersonPerin #CCTRN @ESC_Journals #CardiovascRes
https://t.co/JNcBXQ4BcG
Our study led by @marketrinder shows that, while Lp(a) is an apoB-containing lipoprotein, apoB concentration insufficiently explains CVD risk attributable to Lp(a) (unlike for LDL-C) https://t.co/4Kti7e54El @ESC_Journals #CardiovascRes @zekavatm M. Uddin @akhilp2301
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