Top Tweets for #Senolysis
Senescent cells are cheating metabolism to survive?🧐
Kyoto University finds an abnormal glycolysis trick keeping them alive. Chemical abrogation of this path reverts these phenotypes and eliminates SnCs through #senolysis. #reprogramming @KyotoU_News
https://t.co/AlAfEGoj8l
👏Next up will be Dr. Ippei Shimizu, MD, Director of the Department of Cardiovascular Aging and Heart Failure at the NCVC, Japan. Excited for Dr. Shimizu’s insights on #senolysis and the suppression of pro-fibrotic BATokine become therapies for #cardiovascularmetabolic diseases‼️
#Senolysis is death of senescent cells induced by small molecule inhibitors. Hoque et al. reported effects of ABT-263, a Bcl-2 family inhibitor, on #gemcitabine-induced #senescence of human #pancreatic_cancer cells.
https://t.co/WmH4GTjMQX
#CancerReports #PancreaticCancer
Senotherapy, cancer, and aging https://t.co/tOk9nXpbVc @WilliamDale_MD @rochgerionc @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Senolysis #SenomorphicTherapy #Senotherapy #Chemotherapy
Therapeutic opportunities for #Senolysis in cardiovascular disease
#Atherosclerosis
#MyocardialInfarction
#HeartFailure
#CardioOncology
#PulmonaryHypertension
Jesús Gil lab @FEBSJournal 2023
https://t.co/oN6i33T9TU
Genetic (p16-3MR) vs Pharmacological (ABT263) #Senolysis in ApoE-/-🐭#Atherosclerosis
p16-3MR: No benefits
ABT263:⏬lesion👉senolyis+leukocyte depletion
Proliferating Mφ also p16+;SAβGal+
🧐#Senescence in situ?
Martin Bennett lab #CardiovascRes 2022
https://t.co/V63WKDVz9Q
Increasing serotonin (5-HT) breakdown delays/prevents aging [https://t.co/y5gzuWYZVG] #5-HT #aging #inflammation #lifespan #senescence #senolysis #serotonin #raypeat #idealabs #idealabsdc
Death-Seq
Genome-wide CRISPR screening of Death regulators in adherent cells
Sequencing CRISPR libraries in detached vs attached cells
FoxF1 #Senolysis? Fig 7B😆
Adapted for Adhesion/Extrusion?
@AlexJColville @JieYuLiu4 @Thomas_Rando Cell Metab 2023
https://t.co/bgHrILg6Fj
Interesting talk by @DanielMuozEspn1 showing us that there is a population of scenescent TME cells that can promote #tumourogenesis in lung #adenocarcinoma. Great insights into how #senolysis could be used as a preventative therapy!
#CRUKFunded #EACR2023 @Cambridge_Uni
.@DanielMuozEspn1 will present on clearance of senescent #macrophages ameliorates tumorigenesis in KRAS-driven #LungCancer at 12:45pm (CEST) during #EACR2023's symposium on #TumourDormancy, persistence & #senescence: https://t.co/Mh51LxJ8QA
#CRUKFunded @Cambridge_Uni @EACRnews
Sundeep Khosla chairs Session 2 on "Senescence in Physiology" at #SenescenceInVivo and presents on senescence in bone. Recent publication from the group on local vs systemic #senolysis: https://t.co/AFwUHkNrvR
How Do #Senescent #Cells Fuel Certain #Cancers?
“Forkhead box protein O4 (FOXO4)-DRI peptide interferes with the binding of #FOXO4 to #p53, which occurs in #senescent cells, and this activates #senolysis.”
#Peptides #Senolytic #Peptide #FOXO4DRI #Cancer
https://t.co/J6GMzbx02V
Check here the new work of our group!
@IDM_UPV_UV @CIPFciencia
#senescence #cardiactoxicity #senolysis
The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? #icsa #senescence #sasp #senolysis https://t.co/tJN4r7JcwH
Senolytic #vaccination improves normal and pathological #age-related phenotypes and increases #lifespan in progeroid mice. #geroprotection #senolysis #aging #ageing https://t.co/RcksCUihlG
NEW: In a mouse model of #atherosclerosis, the authors show that #senescent cells inhibit the promigratory phenotype switching of vascular smooth muscle cells by secreting IGFBP3 and that #senolysis promotes the repair of fibrous caps in advanced lesions. https://t.co/3YEs6UhDRZ
Dihomo-15d- #Prostaglandin J2 accumulates within the cell to promote RAS and SASP, whereas #senolytics release Dihomo-15d-PGJ2 from the cell. #senescence #senolysis #aging #ageing https://t.co/lcn8xPKXbn
#Senolysis by #glutamine-olysis inhibition ameliorates various #aging-associated disorders. #senolytics #mitochondria #metabolism #pharma #redox https://t.co/4iiEbqeDl0
Repurposed drug safety assessment using available ocular data! Great collaboration with @SallyLiuBaxter and her team. #glaucoma #senescence #senolysis #aging
Fabulous collaboration with @DrDorotaSK and team members from @ShileyEye to look at the safety of potentially neuroprotective agents for glaucoma!
https://t.co/BQtveq7iJl
#glaucoma #ophthalmology #Aging
ICYMI | In this News&Views, Katharina Wolter & Lars Zender explore how cancer therapies can trigger #senescence of tumour cells and a new study showing that eradication of therapy-induced senescent cells (#senolysis) can improve #LiverCancer therapy
https://t.co/1SIhhgbedY
Clearance of senescent islet cells improves glucose metabolism and β cell function https://t.co/kAmgJCr5j3 #NBThighlight #Senolysis
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