Top Tweets for #ClinicalEquipoise
@kaulcsmc @drpablocorral @DrMarthaGulati @MichaelJBlaha @rblument1 @ProfDFrancis @Guilleresperon @drmikefarkouh would welcome ur collaboration and guidance. Yes if we can come together, possible to make it happen.
As said earlier, till then use #ClinicalEquipoise #BestData & judgement to guide management
Cant hide behind dogma of 'no RCT'
reminds of @Atul_Gawande great humbling message
@JeremyOatesUrol @TheChristieNHS @achoud72 Why wouldnt you tell pts no level 1 data in support of either head to head. And that survival is same. And chance of good function. Patient choice. #clinicalequipoise #EAU22
Brilliant talk by @HBGMD
De-adoption of monitoring (& treatment) in the ICU #clinicalequipoise
#evidencebased
How can we apply this to OSA and CPAP in asymptomatic patients?
When mandates have holes! 💪🏾protest! No to fear mongering!
Bring back the fired heroes who fought the 2 C19 waves! Greatful when media covers the news!
#NoToVaccineMandates #focusedprotection
#clinicalequipoise
#followthescience
#NaturalImmunity
#TeamFiji
Even the mainstream media is impressed with the protests in Australia this weekend.
@lollyfoot @syctong @DrDayaSharma We’ve seen this throughout:
- lopinovir/r 🚮
- hydroxy/chloroquine 🚮
- azithromycin 🚮
- combinations of the above 🚮
- #ivermectin
For whatever reason, perhaps a #cognitivebias towards the need to “do something”, #clinicalequipoise is often lost in #COVID19 to desperation.
If you are looking for the most updated analysis of the concept of #equipoise or #clinicalequipoise you can find it here: https://t.co/UnBvtALZrg. It is critically relevant to this discussion.
🧵I am teaching a class on research ethics at the moment, so it is a good time to discuss whether a randomized controlled trial (RCT) of community masking would be ethical
TL;DR: almost certainly yes
1/
@rallamee Also ULTIMATE because image-guided PCI is what should be done but often isn't..
And REFLECT II: the question of cerebral embolic protection is still out there! #clinicalequipoise
Good @NEJM essay on "A Reminder to Reason"
-With lack of data & emotional drain of sick pts, we understandably rely on anecdotes (ours & others), eg #HCQ
-But we easily fall prey to cognitive error (anchoring & confirmation bias)
#ClinicalEquipoise
https://t.co/TYbyyR8QCh
@Medway_Research @Anaes_Journal @rupert_pearse @_tomabbott @NELANews @rmoonesinghe @doctimcook @elboghdadly @BillFawcett @drlauraduggan @ProfEllenO @traumagasdoc @IainMoppett @AAGBI_President @nicholasalevy @RCoANews Optimise trial design with only key interventions & data points included, ⬆️ research activity & engagement. But always challenging when faced with #clinicalequipoise & the ‘emergency scenario’ quite often deters clinicians even considering including ‘their’ patients into trials!
I perceive lack of #ClinicalEquipoise is a major concern in #RCT #recruitment across the planet. #ANZUP19
This is worrying from @AlisonBirtle: how often do well-meaning clinicians compromise scientifically-justified equipoise when discussing treatment options including #ClinicalTrials? #ANZUP19
@AlisonBirtle success of trials is dependent on the full commitment of ALL investigators and team members to the trial. They must have #ClinicalEquipoise #ANZUP19
How much does this dilemma ring true in clinical practice & recruitment to research trials? Fascinating topic #equipoise #clinicalequipoise #AHPsinresearch #researchrecruitment @ChrisLittlew00d
Does #clinicalequipoise apply to #baskettrials, #umbrellatrials or #adaptive #platformTrials? @SpencerPHey @charlesweijer @akesselheim weigh in @bmj_latest Research ethics for emerging trial designs: does equipoise need to adapt? https://t.co/uJk0pXytLs
A nice, pithy @BMJ head-to-head on #clinicalequipoise for your #researchethics syllabus. I think both sides need some rebuttal space, @SpencerPHey @AlexJohnLondon @CharlesWeijer @Anetrid
https://t.co/hZC1NbnduI
How does it affect duty of care & #clinicalequipoise that trial participants have access to info abt alternatives on their own w/ Internet?
.@AlexJohnLondon on point: is there really "a" scientific community? #clinicalequipoise shld be somewhere btwn individ + monolithic judgment
.@AlexJohnLondon: is #clinicalequipoise about uncertainty in prof community or disagreement between factions each certain they are right
My take: should we really trust IRBs to assess #clinicalequipoise, do they have the right expertise? (Not a knock, just a question)
How 2 rehab #clinicalequipoise, via @charlesweijer: researchers can rely on REC approval unless expert community wld disagree
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