Top Tweets for #Cyclicstretch
Mechanical Control of Inflammation
#CyclicStretch (10% strain, 1 Hz, 6 h) suppresses TNFα-induced Inflammation of 👤Aortic Smooth Muscle Cell on collagen I coating
Independent of NF-κB nuclear translocation🥸
Bulk RNAseq➡️
Comparing 15% (pathological) vs 10% vs static on collagen vs fibronectin vs laminin
scRNAseq➡️
Comparing 10% stretch vs TNF vs 👤#Atherosclerosis (datasets from Wirka Nat Med 2019, Pan Circulation 2020, Alsaigh Commun Biol 2022)
@FiltLise @JulianAljuz bioRxiv 2025
https://t.co/lnBM4t8JOu
#SmoothMuscleCell #Piezo1 #Hypertension
#HydrostaticPressure (200 mmHg), Not #CyclicStretch (18% strain 1 Hz)➡️
⏫GPR146 (+⏬GPR4) in SMC➡️
⏫SMC synthetic phenotype
⏫Cardiomyocyte hypertrophy
⏫cAMP-CREB-Piezo1 (also TRPV4 & KCNK4)➡️ ⏫Systolic & Diastolic Blood Pressure
Evidence from GPR146 KO
SMC-GPR146 KI & KO
AAV2-SM22a-GPR146 & SMC-Piezo1 KO🐭
Jun Cai lab @CircRes 2025
https://t.co/tOod7C5iCZ
#FGF9 Bone
Osteocyte-derived FGF9 mediates Mechanosensitive osteocyte-to-osteoblast/osteoclast communication in Maxillary Bone formation
#CyclicStretch (10%, 20% strain)➡️⏬FGF9 in MC3T3 preosteoblasts (How!?😆)
FGF9⏫ in underdeveloped Maxilla
FGF9 directly⏬osteogenesis &⏫ osteoclastogenesis
(FGF9 downstream: ATF4/5/6 GLI1 GLIS3 NRF1 NR2F1 ZHX2)
A facemask protraction model in mice
A bone-targeted AAV vector (How!?🧐)
FGF9-bound FGFR2 can translocate into nucleolus
#AdvSci 2025 @AdvPortfolio
https://t.co/fVhxcfnElr
#TemporoMandibularJoint #OsteoArthritis
#FGF9/FGFR3 acts as downstream of ⬆️VWA1 in Compensatory responses (⏫ColII ACAN BCL2) of Condylar Cartilage in vivo (#IncreasedOcclusalVerticalDimension Rat 0.5-mm Zr occlusal plate on molars)
& Chondrocyte in vitro (6% #CyclicStretch)
Rac2-p38 works in Decompensatory responses to mechanical stress
@ArthritisRes 2025
https://t.co/unlgSZ1LlU
#SmoothMuscleOnAChip with #CyclicStretch #Proteomics
PDMS #Microfluidic 1-mm-wide channel + pneumatic layer + @Fluigent Push Pull pump
MOVAS SMC in collagen #Hydrogel (Why these cells look round, not spread/elongated?😳)
static vs 7% (physiologic) vs 19% (pathologic) strain
Mechanic stress-induced #ERStress
#AdvSci 2025 @AdvPortfolio
https://t.co/42LcmrlqUJ
#Piezo1 #YAP Bioenergetics #SmoothMuscleCell
Human Umbilical Cord #MesenchymalStromalCell
#CyclicStretch (10% strain, 0.5Hz, 7 d)
#Piezo1-Ca2+ influx➡️
YAP nuclear import (already⏫on 2.5% strain)➡️
⏫MFN1/2 ⏬DRP1➡️
⏫Mitochondrial fusion ⏫mtDNA-encoded genes➡️
⏫OXPHOS (⏫Glycolysis)➡️
⏫SMC contractile proteins
MFN1/2 also reciprocally ⏫nuclear YAP
@FASEBorg 2025
https://t.co/lEwIcey1r5
3D Aortic Valve-On-A-Chip #CalcificAorticValveDisease
2-Layered hydrogel
#ValvularEndothelialCell + #ValvularInterstitialCell in Collagen (Fibrosa)
VIC in Collagen/GAG (Spongiosa)
+Uniaxial #CyclicStretch 10%
#FluorescenceLifetimeImaging #OpticalRedoxRatio
#Proteomics
Modeling early metabolic reprogramming of CAVD
⏬#Glycolysis
+other interesting traits Proteasome, NAD+, Ufmylation...
@IshitaTandon2 @DrKartikBala @ActaBio 2024
https://t.co/UUjG1tLuA5
Stretchable GelMA+Alginate hydrogel-PDMS construct for #SmoothMuscleCell differentiation in 3D
Modify PDMS surface for hydrogel adhesion & whole-construct #CyclicStretch (5% strain, 0.5 Hz)
#3DBioprinting
Dr. Cristian Pennisi lab Biotechnol Bioeng 2023
https://t.co/dVDN2fyTkz
Modeling the roles of #MatrixStiffness & Cell Aspect Ratio in cell re-orientation to #CyclicStretch
"on soft substrates, round-like cells more likely orient themselves in a parallel/perpendicular fashion"
Dr. Luigi Preziosi lab Bull Math Biol 2023
https://t.co/f5QREE8j6D
#NAVBO Member Publication Alert
#CyclicStretch promotes vascular homing of endothelial progenitor cells via Acsl1 regulation of mitochondrial fatty acid oxidation
Dr. Yue Han, John Shyy & Shu Chien groups @PNASNews 2023
https://t.co/aBTgmk4Kia
#Autophagy #Mechanobiology
#CyclicStretch 10% 1.25Hz->
Microtubule depolymerization in venous SMC->
⏬autophagosome-lysosome fusion->
⏫p62 aggregate, binding to KEAP1->
⏫NRF2 antioxidant pathway->
⏫Vein Graft Stenosis
Dr. YX Qi lab @JMCCardiology 2022
https://t.co/a8GRzlRnO2
Biaxial #CyclicStretch (strain 0-12%, 1 Hz, 48 h) on expression of Notch1/2/3, Jag1 & ECM (Collagen, FN) in👤coronary artery #SmoothMuscleCell
Jag1 or DAPT blunts SMC mechanoresponses in Notch & ECM levels🤠
Dr. Sandra Loerakker lab @FrontCellDevBio 2022
https://t.co/ztkM6L8MHl
#CircRNA #SmoothMuscleCell #Mechanobiology
circSlc8a1 -> miR-20a-5p -> Lamtor1 bridges #CyclicStretch with mTORC1-mediated #Neointima (SMC prolferation/migration) of🐭vein graft
Dr. Ming-Liang Zhang, Zong-Lai Jiang & Ying-Xin Qi labs @THNOdotORG 2022
https://t.co/4sYjgcxd1C
ECM #Calcification (mediated by Asporin) blunted the mechanoresponse of fibroblast to #CyclicStretch
-Alignment
-Collagen remodeling
-Myofibroblast differentiation
A biomechanical cue for #Keloid pathology
Dr. Yanan Du & Chenyu Huang lab, FASEB J 2022
https://t.co/4Gi8lraC6O
3D PDMS-GelMA #CyclicStretch #MicrophysiologicalSystem for Aortic #SmoothMuscleCell
Enables Thoracic #AorticAneurysm patient-specific SMC-targeting drug screening🤠
#PersonalizedMedicine
Dr. Chunsheng Wang, Kai Zhu, Weijia Zhang labs @eBioMedicine 2022
https://t.co/TThNHhjx4P
#Mechanocrine🤠
#CyclicStretch⏫#LiverSinusoidalEndothelialCell Secretion of CXCL1 -> #Neutrophil/#NETosis/Microthrombi-> Liver #PortalHypertension
In LSEC: Stretch-> Integrin/#Piezo1-> Notch1-> CXCL1
Dr. Vijay Shah lab @AGA_Gastro 2019 @Dr_Vijay_Shah
https://t.co/DdcKaWq8zh
Mechanosensing behaviors of #EndothelialCell in response to 1D, 2D circumferential, 3D radial #CyclicStretch
15% linear strain, 0.2 Hz, PDMS membrane deformation
Alignment, Junction, #FocalAdhesion, #YAP
Dr. Yong Yang lab, ACS Appl Mater Interfaces 2022
https://t.co/z7pOVLAZiy
#CyclicStretch (3% strain 1Hz) ⏫ the cytosolic translocation & secretion of HMGB1, a DAMP, in rat aortic #SmoothMuscleCell, dependent on PDGFRβ (Not PDGFRα/IGFR/EGFR/FGFR)
Love to see mechanosensitive SMC secretome🤓
Dr. Chi Dae Kim lab @PLOSONE 2022
https://t.co/YbYLckYDTx
The effects of #CyclicStretch on material uptakes are complex & cargo-dependent
Plasmid DNA
https://t.co/OhJ7y5tCuB
Lipid Nanoparticle
https://t.co/T3uCIHUEih
Silica Nanoparticle
https://t.co/syaDtd0gqe
Difference b/w apical & basolateral membrane
https://t.co/t4VSCsKRID
...
#CyclicStretch (1Hz, 10% strain)⏬poly(acrylic acid)-#MagneticNanoparticle Internalization in SHR rat Aortic #SmoothMuscleCell & LN-229 Glioblastoma cell
Evident roles of surface membrane & actin dynamics
Dr. Yunn-Hwa Ma lab, Int J Nanomedicine 2022
https://t.co/I1tZ4YsIBA
Last Seen Hashtags on Sotwe
CaughtOnCamera(***)+filter:videos
Seen from Germany
mnwo #caption
Seen from Singapore
绿帽
แนวครอบครัวแม่ลูก
Seen from Thailand
varka
WomensHygiene
Seen from United States
bocil()****** filter:videos
Seen from Turkey
使用済下着
Seen from Japan
นัดเย็ดอุทุมพร
Seen from Thailand
porn #blonde
Seen from Turkey
Trends for you
Most Popular Users
Elon Musk 
@elonmusk
241.5M followers
Barack Obama
@barackobama
118.9M followers
Cristiano Ronaldo
@cristiano
114.6M followers
Donald J. Trump
@realdonaldtrump
111.8M followers
Narendra Modi
@narendramodi
107.1M followers
Rihanna
@rihanna
98.7M followers
NASA
@nasa
92.3M followers
Justin Bieber
@justinbieber
91.8M followers
KATY PERRY
@katyperry
90M followers
Taylor Swift
@taylorswift13
84M followers
Lady Gaga
@ladygaga
75.5M followers
Virat Kohli
@imvkohli
73.5M followers
Kim Kardashian
@kimkardashian
70.9M followers
YouTube
@youtube
68.8M followers
Neymar Jr
@neymarjr
66.5M followers
Bill Gates
@billgates
65.2M followers
Selena Gomez
@selenagomez
63.1M followers
The Ellen Show
@theellenshow
62.2M followers
CNN
@cnn
61.8M followers
X
@x
60.7M followers