Top Tweets for #DNMT3a
Rethinking Myeloid Precursor Disease in 2025 - Abdul Mannan
https://t.co/ELJADZGAH6
#ASXL1 #BCUHB #CCMUS #CCUS #CHIP #DNMT3A #ClonalHaematopoiesis #CMUS #Hematology #TET2 #Hemostasis #HemostasisToday #JAK2 #Medicine #MyeloidPrecursorDisease #Thrombosis #Health #MedEd #MedX
Impact of Epigenetic Mutations in Chronic Myelomonocytic Leukemia - PubMed #CMML #ASXL1 #DNMT3A #TET2 @MayoCancerCare https://t.co/IoehsgrXP7
Intresting article in @Nature showed that #metformin led to a markedly lower prevalence of #DNMT3A R822-mutant clonal hematopoiesis #CH
💡Could metofrmin to prevent progression to #AML❓
@OncoAlert #leusm #CHIP #MDS
https://t.co/hD3B7nzcqp
🚨 A new episode is out!
Dr. Margaret "Peggy" Goodell (@Goodell_Lab) from @bcmhouston talks about her seminal discovery of a side population of HSCs, as well as her work on #DNMT3A mutation and clonal #hematopoiesis of indeterminate potential. 🩸
🎧 https://t.co/sInIzTQ2VA
In addition, they looked at data from 412,000 UK Biobank volunteers & found people taking metformin were less likely to have changes in #DNMT3A gene. This link remained even after accounting for factors that could have confounded results, such as diabetes status and BMI. 8/
Researchers investigated how to prevent abnormal blood stem cells with genetic changes from progressing to become AML. The work focused on the most common genetic change, which affects a gene called #DNMT3A and is responsible for starting 10–15% of AML cases. 4/
Excited to share the @Goodell_Lab News&Views on 3 exciting studies by @VassiliouLab, Chan Lab, and @TrowbridgeLab in @Nature and @NatureComms, showing that blood stem cells with mutant #DNMT3A (major driver of Clonal Hematopoiesis) depend on enhanced mitochondrial respiration ⬇️
Congratulations to Prof. Andreas and the team on the impressive publication in Blood, and highlighting the impact of recurrent blood donations on donor health and HSCs ... Well done 💪
#blood #Donation #HSCs #DNMT3A #clonal_hematopoisis #Trumpp_Andreas #Darja_karpova
🩸Functional analysis of frequent donor enriched DNMT3A variants examined in CRISPR-edited human HSCs demonstrated their competitive outgrowth potential upon stimulation with #erythropoietin.
This study was led by Drs. @DarjaK1 and Andreas Trumpp.
🔎 https://t.co/Mw7kJTZLa9
Beautifully presented configuration of the clonal hematopoiesis landscape in frequent blood donors by Dr. Darja Karpova.
#ESHMICRO2025 #ESHCONFERENCES #EPO #DNMT3A
Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response https://t.co/wRyZMmx9yL Why does #DNMT3A #CH increase mortality in the context of #COVID19 and #VEXAS #multiomics @MayoCancerCare @LFE_Maialab
#SfN24 #DNAmethylation #engram #memory #Dnmt3a our SFN friends, come to our poster, say hi, and learn more about our research on methylation in memory from @ShawnLiu_Lab and @YueqingPeng labs!! 🔥🔥💥💥 https://t.co/sK8rg5Wan0
Clonal hematopoiesis drives femoral atherosclerosis in middle-aged adults 🔬❤️📊 https://t.co/IrVyQCbD68 #CardiovascularResearch #Atherosclerosis #ClonalHematopoiesis #GeneticMutations #DNMT3A #TET2 #Heart #MiddleAge #PreventiveMedicine #Health @NatureMedicine
Outcome of #NPM1m #AML
⭐️ #FLT3_ITD #DNMT3A #WT1 and #non_ABD_NPM1 ⬇️ OS, ⬆️ relapse , ⬆️ MRD+
⭐️ MRD- after 2 cycles is predictive of outcome
⭐️ ⬆️ salvage flag-Ida for mrd+ ⬆️OS, ⬇️ relapse
@BloodJournal
Molecular, clinical, and therapeutic determinants of outcome in NPM1-mutated AML https://t.co/7WCsLaVfUV
Embryonic-derived mosaicism is likely highly under-appreciated and yet can have significant implications for the identification, management, and transmission of a variety of conditions. Eg #TBRS #DNMT3A @TBRSCommunity
https://t.co/KcLRUEheA9
👉👉👉Appreciated the chance to exchange ideas 💡 & catch up with .@jaiswalmdphd today as he is visiting @MDAndersonNews as invited guest speaker for his pioneering work in CHIP! Wonderful visit. #CHIPsm #MDSsm #MPNSM #TET2 #JAK2 #DNMT3A #ASXL1 #TCL1A
.@fengyang0415, @gur_ola et al. show that hematopoietic-specific heterozygous loss of #Dnmt3a exacerbates #colitis-associated #ColonCancer. https://t.co/U306P07Ba0
From JEM #Cancer Collection ➡️ https://t.co/ZSorwcUVm5
#AACR2024
Loss of Dnmt3a increases self-renewal of JAK2V617F HSCs - @Wang_Yu_Hung
@BloodJournal
#Cancer #DNMT3A #JAK2MutAllele #JAK2V617F #MPN #OncoDaily #Oncology #PegIFNα
https://t.co/Y5JXsTlYfH
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