Top Tweets for #DoseOptimization
Thank you @SenatorChoi for taking the time to listen to my Crohn’s disease journey & being open to understanding the reasons why SB-964 is so important! Dose optimization should NOT require prior authorizations 😠 #IBDAdvocacy #SB964 #DoseOptimization #IBD
#DoseOptimization in Oncology Drugs - a 🧵 #bcsm
1/ “The modern drug development paradigm in oncology should recognize that the MTD is not necessarily the optimal dose… phase I trials should determine a range of dosages.” —FDA/ASCO guidance (July 2025)
👉 https://t.co/NEgPEEbtAu
4/ Dosing isn’t just a science issue. It’s a quality of life issue—especially for people on treatment for the long haul. Read the article online https://t.co/NngFYo7Z5m #DoseOptimization #MBC #Oncology 🧵
🔟 Action needed on dose titration!
🔊 Loud message: Starting therapy isn’t enough—optimize dosing continuously to ensure max benefits.
#DoseOptimization #GDMT [11/11]
Proud to share our review in Cancer Treatment Reviews:
We explore how trial designs are evolving to prioritize safety, biomarkers & patient-centered care.
Thanks to Prof. @curijoey and @darioT_
#Oncology #DoseOptimization #CancerTrials @OncoAlert
Proud to share our review in Cancer Treatment Reviews:
We explore how trial designs are evolving to prioritize safety, biomarkers & patient-centered care.
Thanks to @DarioTrapani & Prof. @curijoey !
#Oncology #DoseOptimization #CancerTrials
https://t.co/g28YItQYSd
Nectin-4 PET For Optimizing Enfortumab Vedotin Dose-Response In Urothelial Carcinoma https://t.co/AAyLd28MYV
@484Mishra @djmcconkey @Imaging4Health
#Nectin4 #Enfortumabvedotin #ADC #antibodydrugconjugates #doseoptimization #PETimaging #JHU #JHMI #Bladdercancer
A new era in dosing for people with #breastcancer. #doseoptimization helps people stay on treatment longer and miss less. Get the latest from #SABCS24. https://t.co/4nJecAFJmx
“We don’t just want to live long. We want to live well.” - Julia Maués, co-founder of @the_rightdose
Excited to support my friend, & #PCDI lead @itsnot_pink as she represents @The_Right_Dose, bringing invaluable patient expertise on #doseoptimization to #SABCS24!
Changing the conversation, moving away from #MTD, toward #PersonalizedMedicine in #Oncology.
#SABCS24
@SA@SABCSSanAntonio
#bcsm
Dr. Patricia LoRusso, “make every patient count & make the drug count in every patient!”
#DoseOptimization
#PCDI
@The_Right_Dose
#bcsm
@SABCSSanAntonio
#SABCS24
Important FDA special session at #SABCS24! Grateful to @awolff for championing the shift from #MTD to minimum effective dose in #clinicaltrials.
Follow @The_Right_Dose (PCDI) for updates on #doseoptimization in #metastaticbreastcancer. It’s not just about living longer—it’s about living better! #QoLmatters
@SABCSSanAntonio
@OncoAlert
#bcsm
#DoseOptimization
🙌 Hmm.. who can we tag for this? 🧐
Funding #DoseOptimization studies would be helpful, too!
#bcsm
#cancer
“Five patients treated with the antibody-drug conjugate (ADC) in the YL202-INT-101-01 trial and the phase 2 YL202-CN-201-01 trial (NCT06107686) experienced grade 5 adverse effects (AEs).”
Grade 5 is ☠️
#bcsm
#lcsm
#toxicities
#CancerResearch
#DoseOptimization
Repeat, again & again - #doseoptimization
“The lower dose of T-DXd (5.4 mg/kg) led to higher ORR and longer PFS than the higher dose (6.4 mg/kg), with nearly HALF the rate of ILD. Less can be more!”
Although not #metastaticbreastcancer specific, dosing, efficacy, and QoL for patients using these targeted therapies utilized across multiple #cancers, is important to understand. Evidence exists - we simply need to look for it ~ then put it in practice!
The #RightDose for the #RightPatient at the #RightTime
#PersonalizedMedicine
#PrecisionMedicine
#bcsm
#QoLMatters
#TxRelatedToxicities
https://t.co/VhFZ1NQBwN
#PCDI
Similar to DESTINY-CRC01, most responses were seen in HER2 IHC 3+ tumors. HER2 expression does matter, for T-DXd efficacy.
Speaking on #doseoptimization, “We want to live as long as possible, but not at any price,” said Julia Maues (@itsnot_pink) who has #metastaticbreastcancer. “What we want is to balance treatment with quality of life.”
https://t.co/eRk67bIBk5
#bcsm https://t.co/fHu72hJGyF
Speaking on #doseoptimization, “We want to live as long as possible, but not at any price,” said Julia Maues (@itsnot_pink) who has #metastaticbreastcancer. “What we want is to balance treatment with quality of life.”
https://t.co/eRk67bIBk5
#bcsm https://t.co/fHu72hJGyF
This👉🏻“No camizestrant dose reduction or discontinuation secondary to TRAEs was reported for doses of 150 mg and below.”
With similar ORR, CBR, mPFS @ lower doses. Hopeful Camizestrant cont’s to show promise for HR+ MBC!
#DoseOptimization
#QoL
#bcsm
#metastaticbreastcancer
I obviously quote tweeted another @Annals_Oncology article 😅
https://t.co/xA9OeLkQ5e
#bcsm #ESMOBreast24
#DoseOptimization “It's the right thing to do for our patients,” says Mikkael Sekeres, MD. Does drug $$ matter? “Each milligram of drug doesn't have an inherent value.” Optimal dosing w/⬇️toxicities, pts are likely to remain on tx longer= win/win! #bcsm https://t.co/j4UiUGR8uW
Cody Chiuzan and Hakim-Moulay Dehbi demonstrate that for early phase clinical trials the 3+3 design is consistently outperformed by model-based designs which offer improved efficiency and precision in determining the MTD. @Cchiuzan @SCTorg @LGM_biostats #doseoptimization
Researchers from Columbia University and Université de Paris Cité illustrate the importance of using designs that include late-onset toxicities in dose-finding clinical trials. @uni_uparis @BiardLucie @SCTorg @LGM_biostats #doseoptimization #FDA
Last Seen Hashtags on Sotwe
fat
Seen from United States
CallOfClaymore
Seen from Malaysia
teadorarémeuprazer
Seen from Brazil
24hourslumberparty
Seen from Belgium
時田萌子生誕祭
Seen from United States
CleanUpcargill
Seen from New Zealand
pregnancy
Seen from United States
public handjob
Seen from Singapore
ms sethi
Seen from Netherlands
lakshmideeptha
Seen from Singapore
Most Popular Users
Elon Musk 
@elonmusk
240.2M followers
Barack Obama
@barackobama
119.3M followers
Donald J. Trump
@realdonaldtrump
111.6M followers
Cristiano Ronaldo
@cristiano
109M followers
Narendra Modi
@narendramodi
107M followers
Rihanna
@rihanna
97.3M followers
NASA
@nasa
92.1M followers
Justin Bieber
@justinbieber
90.6M followers
KATY PERRY
@katyperry
86.9M followers
Taylor Swift
@taylorswift13
80.7M followers
Lady Gaga
@ladygaga
72.2M followers
Kim Kardashian
@kimkardashian
69.4M followers
YouTube
@youtube
68.6M followers
Virat Kohli
@imvkohli
68.6M followers
Bill Gates
@billgates
63.4M followers
The Ellen Show
@theellenshow
62.5M followers
CNN
@cnn
61.9M followers
Neymar Jr
@neymarjr
61.2M followers
X
@x
60.9M followers
Selena Gomez
@selenagomez
60M followers