Top Tweets for #doseoptimization
Thank you @SenatorChoi for taking the time to listen to my Crohn’s disease journey & being open to understanding the reasons why SB-964 is so important! Dose optimization should NOT require prior authorizations 😠 #IBDAdvocacy #SB964 #DoseOptimization #IBD
#DoseOptimization in Oncology Drugs - a 🧵 #bcsm
1/ “The modern drug development paradigm in oncology should recognize that the MTD is not necessarily the optimal dose… phase I trials should determine a range of dosages.” —FDA/ASCO guidance (July 2025)
👉 https://t.co/NEgPEEbtAu
4/ Dosing isn’t just a science issue. It’s a quality of life issue—especially for people on treatment for the long haul. Read the article online https://t.co/NngFYo7Z5m #DoseOptimization #MBC #Oncology 🧵
🔟 Action needed on dose titration!
🔊 Loud message: Starting therapy isn’t enough—optimize dosing continuously to ensure max benefits.
#DoseOptimization #GDMT [11/11]
Proud to share our review in Cancer Treatment Reviews:
We explore how trial designs are evolving to prioritize safety, biomarkers & patient-centered care.
Thanks to Prof. @curijoey and @darioT_
#Oncology #DoseOptimization #CancerTrials @OncoAlert
Proud to share our review in Cancer Treatment Reviews:
We explore how trial designs are evolving to prioritize safety, biomarkers & patient-centered care.
Thanks to @DarioTrapani & Prof. @curijoey !
#Oncology #DoseOptimization #CancerTrials
https://t.co/g28YItQYSd
Nectin-4 PET For Optimizing Enfortumab Vedotin Dose-Response In Urothelial Carcinoma https://t.co/AAyLd28MYV
@484Mishra @djmcconkey @Imaging4Health
#Nectin4 #Enfortumabvedotin #ADC #antibodydrugconjugates #doseoptimization #PETimaging #JHU #JHMI #Bladdercancer
A new era in dosing for people with #breastcancer. #doseoptimization helps people stay on treatment longer and miss less. Get the latest from #SABCS24. https://t.co/4nJecAFJmx
“We don’t just want to live long. We want to live well.” - Julia Maués, co-founder of @the_rightdose
Excited to support my friend, & #PCDI lead @itsnot_pink as she represents @The_Right_Dose, bringing invaluable patient expertise on #doseoptimization to #SABCS24!
Changing the conversation, moving away from #MTD, toward #PersonalizedMedicine in #Oncology.
#SABCS24
@SA@SABCSSanAntonio
#bcsm
Dr. Patricia LoRusso, “make every patient count & make the drug count in every patient!”
#DoseOptimization
#PCDI
@The_Right_Dose
#bcsm
@SABCSSanAntonio
#SABCS24
Important FDA special session at #SABCS24! Grateful to @awolff for championing the shift from #MTD to minimum effective dose in #clinicaltrials.
Follow @The_Right_Dose (PCDI) for updates on #doseoptimization in #metastaticbreastcancer. It’s not just about living longer—it’s about living better! #QoLmatters
@SABCSSanAntonio
@OncoAlert
#bcsm
#DoseOptimization
🙌 Hmm.. who can we tag for this? 🧐
Funding #DoseOptimization studies would be helpful, too!
#bcsm
#cancer
���Five patients treated with the antibody-drug conjugate (ADC) in the YL202-INT-101-01 trial and the phase 2 YL202-CN-201-01 trial (NCT06107686) experienced grade 5 adverse effects (AEs).”
Grade 5 is ☠️
#bcsm
#lcsm
#toxicities
#CancerResearch
#DoseOptimization
Repeat, again & again - #doseoptimization
“The lower dose of T-DXd (5.4 mg/kg) led to higher ORR and longer PFS than the higher dose (6.4 mg/kg), with nearly HALF the rate of ILD. Less can be more!”
Although not #metastaticbreastcancer specific, dosing, efficacy, and QoL for patients using these targeted therapies utilized across multiple #cancers, is important to understand. Evidence exists - we simply need to look for it ~ then put it in practice!
The #RightDose for the #RightPatient at the #RightTime
#PersonalizedMedicine
#PrecisionMedicine
#bcsm
#QoLMatters
#TxRelatedToxicities
https://t.co/VhFZ1NQBwN
#PCDI
Similar to DESTINY-CRC01, most responses were seen in HER2 IHC 3+ tumors. HER2 expression does matter, for T-DXd efficacy.
Speaking on #doseoptimization, “We want to live as long as possible, but not at any price,” said Julia Maues (@itsnot_pink) who has #metastaticbreastcancer. “What we want is to balance treatment with quality of life.”
https://t.co/eRk67bIBk5
#bcsm https://t.co/fHu72hJGyF
Speaking on #doseoptimization, “We want to live as long as possible, but not at any price,” said Julia Maues (@itsnot_pink) who has #metastaticbreastcancer. “What we want is to balance treatment with quality of life.”
https://t.co/eRk67bIBk5
#bcsm https://t.co/fHu72hJGyF
This👉🏻“No camizestrant dose reduction or discontinuation secondary to TRAEs was reported for doses of 150 mg and below.”
With similar ORR, CBR, mPFS @ lower doses. Hopeful Camizestrant cont’s to show promise for HR+ MBC!
#DoseOptimization
#QoL
#bcsm
#metastaticbreastcancer
I obviously quote tweeted another @Annals_Oncology article 😅
https://t.co/xA9OeLkQ5e
#bcsm #ESMOBreast24
#DoseOptimization “It's the right thing to do for our patients,” says Mikkael Sekeres, MD. Does drug $$ matter? “Each milligram of drug doesn't have an inherent value.” Optimal dosing w/⬇️toxicities, pts are likely to remain on tx longer= win/win! #bcsm https://t.co/j4UiUGR8uW
Cody Chiuzan and Hakim-Moulay Dehbi demonstrate that for early phase clinical trials the 3+3 design is consistently outperformed by model-based designs which offer improved efficiency and precision in determining the MTD. @Cchiuzan @SCTorg @LGM_biostats #doseoptimization
Researchers from Columbia University and Université de Paris Cité illustrate the importance of using designs that include late-onset toxicities in dose-finding clinical trials. @uni_uparis @BiardLucie @SCTorg @LGM_biostats #doseoptimization #FDA
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