Top Tweets for #GALACTICHF
Serum magnesium and outcomes in heart failure with reduced ejection fraction: the GALACTIC-HF trial. Read more in the #EHJ at https://t.co/SvMHZXQfi0 #HeartFailure #GALACTICHF #Magnesium @ESCardio @ESC_Journals
@abdelhamed012 @brendonneuen @MkosiborodMD @AndrewJSauer @GoggleDocs @paomorejon @ValleAlfonso @drkevinfernando @escardio @MarcoMetra @ShelleyZieroth Last large HFrEF RCT #GALACTICHF w a mean BMI of 29—the majority of whom meet #SELECT BMI thresholds of above 27kg/m2.
https://t.co/lFW9xNUJYM
Globally, people with HFrEF are more commonly overweight or obese, especially when accounting for ethnicity-appropriate thresholds
Relationship between #TricuspidRegurgitation x #HFrEF❓
🫀Moderate/severe TR ⬆️ risk of HF events& #CVdeath, highlighting the importance of managing TR in HF‼️
🫀Omecamtiv mecarbil was effective regardless of TR severity
More 🖇️: https://t.co/qTIbkT1jt3 #JACCHF #GALACTICHF
Initial reaction (2/3):
-Urgent HF contributed to a miniscule % of the 1º composite endpoint...certainly did *not* drive Rx benefit (173 of 3,130 events)
-Decision-making based on LVEF measured in last yr is standard of care!
-Background Rx in #GALACTICHF best of modern HF RCTs
Thanks to @jteerlinkmd @MyosinMD @HeitnerStephen for the opportunity to present some new data from #GALACTICHF at #ACC22 on the effect of OM in inpatients and outpatients enrolled in the trial as part of a great session on HF clinical trial updates
Thanks to @jteerlinkmd @MyosinMD @HeitnerStephen for the opportunity to present some new data from #GALACTICHF at #ACC22 on the effect of OM in inpatients and outpatients enrolled in the trial as part of a great session on HF clinical trial updates
Enroute to #ACC22 - looking forward to seeing the results of #METEORICHF presented by @DukeHFDoc and also present some new data from #GALACTICHF on Monday.
Discover upcoming sessions on factors that contribute to patient drop off, the role of omecamtiv mecarbil with #GALACTICHF, and genetic variants that shape the cardiovascular outcomes of #breastcancer patients at #ACC22.
https://t.co/XZajDTmBWR
@jennkwanMDPhD @DrKristieHarris
Just published in EHJ‼️
How does #Afib influence efficacy of omecamtiv mercabil in #GALACTIC HF?
➡️ important to note that not necessarily Digoxin is to blame, but that Digoxin use identifies a highly vulnerable population
https://t.co/VDOo0dRAF5
@ehj_ed @ESC_Journals
📌Influence of atrial fibrillation on efficacy & safety of #omecamtiv mecarbil in HF: #GALACTICHF trial
#CardioEd #CardioTwitter
.@US_FDA #NDA filed for first-in-class selective cardiac myosin activator #OmecamptivMecarbil in #HFrEF after successful P3 #GALACTICHF. PDUFA target action date in Nov '22.
Excited for #METEORICHF LBCT #ACC22 @GLewisCardiol @DukeHFDoc
Incredible journey @MyosinMD @jteerlinkmd!
Important & robust finding from #GALACTICHF
ACEi (#SOLVD) ARB (#CHARM) & MRA (#EMPHASIS) ↓ incident AF, however this is 1 of the first that ↓ #stroke in HF. Sotagliflozin (#SOLOIST/#SCORED) & rivaroxaban in sinus (#COMMANDER) ↓ stroke, but aren't available for this indication
#HeartFailure2021 LBT: A New analysis from the #GALACTIC_HF trial suggests a possible negative interaction between omecamtiv mecarbil and digoxin in patients with atrial fibrillation/flutter but no such interaction in sinus rhythm
#GALACTICHF #HF #heartfailure #HFA_ESC
Today we announced additional results from #GALACTICHF in #HeartFailure at @escardio’s #HeartFailure2021. https://t.co/DWgpAoBnJH
#HFA_ESC #CardioTwitter
Latest publication from the #GALACTICHF team on omecamtiv mecarbil in HFrEF:
Effect of Ejection Fraction on Clinical Outcomes in Patients treated with Omecamtiv Mecarbil in GALACTIC-HF
Effect of OM was greater in those with lower EF%
https://t.co/rrFwTiAKHQ
#GALACTICHF #ACC21 GALACTICHF: omecamtiv mecarbil reduces heart failure hospitalizations by a greater margin among patients with more severely reduced ejection fraction.👍
Today @jteerlinkmd presented results of a secondary analysis from #GALACTICHF in #HeartFailure, which were simultaneously published in @JACCJournals #JACC #LBCT.
https://t.co/qVw8LHVXNd
LVEF, with all its limitations & imprecision, continues to be a powerful marker to identify responders for many Rx
Strong Rx interaction (P=0.004) in #GALACTICHF: Magnified benefits with ↓ LVEF, in keeping w mechanism of OM
#ACC21 @JACCJournals #SimPub:
https://t.co/RrUmBq7c8o
#ACC21 #JACC LBCT SimPub: New analysis from #GALACTIC-HF demonstrates increasing magnitude of treatment effect of #omecamtiv mecarbil in #HFrEF patients with more reduced EF. https://t.co/99U1jrWhSt
#CardioTwitter #MedTwitter #Heartfailure @jteerlinkmd
2/2
#ACC21 | #GALACTICHF:
Omecamtiv mecarbil ⬇️ HF hospitalizations by a greater margin among patients with more severely ⬇️ EF
❌adverse effect on HR,K+,BP or Cr
@jteerlinkmd
@JACCJournals 🔗 https://t.co/v8XwIpa5kZ
@ACCinTouch #ACC21 #ACCFIT
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