Top Tweets for #GDFATHERNeo
With #GDFatherNeo #ESMO26 We brought visugromab+nivo combination neoadjuvantly in pts with MIBC after the initial phase 1 data in refractory setting.
33% CR rates vs 8% Nivo+placebo
All pCR pts still event-free (median FUP 15.7m)
Only 1 relapse event in major responders in N+V arm (pTa relapse)
4/5 pCR skipped RC in N+V arm.
Safety was quite good.
Pre-existing CD8+ infiltration associated with N+V Response.
It was an illuminating academic-industry collaboration for me.
Results simultaneously released today in @NatureMedicine
@myESMO @CMercinelli @Anto_cigliola @BrigidaMaiorano @giannatempopatr @DrIacovelli @ciccarese_c and Many more @SanRaffaeleMI @MyUniSR
https://t.co/RUvImBFXs9
Happy to share two additional 🧩 of the neoadjuvant/perioperative puzzle of MIBC slated to be disclosed #ESMO26
- Friday 23 Oct: CA078 trial (#ENERGIZE) Randomized phase III periop Nivo-GC vs GC
- Sat 24 Oct: Long term results of #GDFATHERNeo Phase II neoadj Nivo + Visugromab vs placebo #GFD15
@myESMO @OncoAlert @sonpavde @shilpaonc @SanRaffaeleMI @MyUniSR @urotoday

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