Top Tweets for #KEYNOTE177
📍#KEYNOTE177 confirma el impacto de #pembrolizumab en #mCRC MSI-H/dMMR con>5 años de seguimiento:
https://t.co/XX2t8L0SOy
🔹Mediana de SG: 77,5 vs 36,7 meses (HR 0,73)
🔹SG a 5 años: 54,8% vs 44,2%
🔹Mediana de SLP: 16,5 vs 8,2 meses (HR 0,60)
#Pembrolizumab continued to show durable antitumour activity compared with chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic #ColorectalCancer, #KEYNOTE177 study finds
10.1016/S1470-2045(22)00197-8
Our new paper is out - great collaboration with @lab_pearson from @UChiPritzker 🇪🇺🇺🇸 #AI based #MSI testing in #colorectal #cancer could save 💵💶 @UniklinikAachen @NCT_HD @rwth #keynote177
Q: How could #digitalpathology #AI affect cancer healthcare systems cost and care delivery if we deployed existing models *today*? 🤖vs🦀
Check out our new cost-model use case manuscript in @FrontiersIn @FrontOncology:
https://t.co/yC19L0xzkS
#GI21 #ASCOGI21 @ASCO
#KEYNOTE177: Phase III randomized study of #pembrolizumab vs #chemotherapy for #microsatelliteInstabilityHigh advanced #ColorectalCancer
@ASCO_pubs @pashtoonkasi @NiuSanford
@realbowtiedoc @ShaalanBeg @PamelaKunzMD
🗞 L'article, publicat recentment a @NatRevClinOncol, aprofundeix sobre l'assaig #KEYNOTE177 i compta amb el punt de vista de @TaberneroJosep, director del VHIO, sobre la importància de l'estudi per als pacients amb càncer colorectal.👇 https://t.co/Qx5bACK4ce
🗞 El artículo, publicado recientemente en @NatRevClinOncol, profundiza sobre el ensayo #KEYNOTE177 y cuenta con el punto de vista de @TaberneroJosep, director del VHIO, sobre la importancia de este estudio para los pacientes con cáncer colorrectal.👇https://t.co/7KoVRssw2w
Happy to share our map of #CRC response to immunotherapy incl. #KEYNOTE177 samples. Huge effort by @RedaKeddar @AmeAchaSag Michele, Lucia (not on Twitter) @JoSpencerLab clinical colleagues @uclcancer fabulous STPs @TheCrick and many more. Summary 👇 1/8 https://t.co/vklPXFti7F
#Pembrolizumab in Microsatellite-Instability–High #Advanced #ColorectalCancer #KEYNOTE177
@pashtoonkasi @LorenzaRimassa @fireflyann @ShuchiGulati
https://t.co/INJg99lHuk
How do we interpret future 1st line ICB studies when a significant % of pts receive IO in later lines of treatment? Striking lack of OS benefit in #attraction4 , while PFS sign better. May be the case for #keynote177 in dMMR #crc as well #ESMO20
#KeyNote177 looking at Quality of Life for #MSI #colorectalcancer - physical as well as social functioning.
#ESMO20 #CRCSM
Andre et al, KEYNOTE-177 QoL results
Pembro vs standard chemotherapy in MSI-H/dMMR mCCR:
- better health-related QoL
- prolonged TTD for global health status/QoL (HR 0.61), physical functioning (HR 0.50), social functioning (HR 0.53) and fatigue (HR 0.48)
#ESMO20
As per Thierry Andre on todays #ESMO20 meeting we will likely not know which pts on #Keynote177 were germline Lynch vs. somatic MSI-H mutated #colorectal #cancer patients. #crcsm @VUMC_Cancer @VUMChealth #clinicaltrials #cancerresearch @Merck @OncoAlert
#ESMO20
#6 on @PTarantinoMD Top 10 list
#KeyNote177 - Quality of Life for #MSI #ColorectalCancer patients receiving Pembro in the 1st line.
#CRCSM #OncoAlert
Hard, yet exciting exercise, trying to pick a TOP10 of upcoming #ESMO20 Abstracts
A multitude of practice-changing trials in breast, lung, gastric cancer, CRC and so much more!
Don’t miss this important appointment - registration still open, free for @myESMO members!
@OncoAlert
#WorldGI2020 👇🏾THIS is what we need to figure out.
Who are these MSI⬆️patients who don’t respond to upfront #immunotherapy. 💡
🔴True progression
🟡?not true dMMR (confirm MSI/NGS)
🟢TMB
🟠?KRAS➕
🟣host immune system📉
Other thoughts/ideas❓
@myESMO @OncoAlert
#CRCSM
OncKIP faculty member @BraghiroliIgnez shares a personal highlight from #ASCO20: results from #KEYNOTE177 study of pembrolizumab vs. chemotherapy in MSI-H/dMMR metastatic colorectal cancer #crcsm
Great news for US patients with MSI metastatic #colorectalcancer . Hopefully Europe will follow soon. Hope to see the publication of #keynote177 soon!
Just Out📣 @US_FDA 🇺🇸Approves1️⃣st Line pembrolizumab in MSI-H/dMMR 🧬Metastatic #ColorectalCancer
This marks the 1️⃣st #immunotherapy approved for this patient population as 1️⃣st line treatment & administered without also giving #chemotherapy 🧪
https://t.co/CWOGieBNdh
#Pembrolizumab should be considered a new standard of care as first-line therapy for MSI-H metastatic #colorectalcancer, says Thierry Andre. Slides are from a press preview. Full data to be presented as LBA4 during the plenary. https://t.co/go6fgnH4KO #ASCO20 #ASCO2020 #crcsm
Just in time for the FDA approval!
(of Pembrolizumab in the 1st line for #MSI #colorectalcancer)
Dr. Weinberg discusses #KeyNote177 during first 7 minutes - some interesting comments re possible future directions
@benweinbergmd
JUST RELEASED: In our latest episode of #OncLiveOnAir, @benweinbergmd, of @LombardiCancer, discusses the clinical implications of recent data presented at the 2020 ASCO Virtual Scientific Program on the treatment of CRC. #ASCO20 #crcsm Listen now: https://t.co/JzDPZCiHaW
June IS Immunotherapy Month...
what with TWO FDA approvals for I/O in #colorectalcancer
But good to remember all the points brought up in #KeyNote177 so that the research keeps moving forward and the best therapy is found for #MSI patients (and hope that helps MSS pts).
#CIM20
#ASCO20 Excellent discussion from prof. Overman on practice-changing results of #Keynote 177, raised questions & next steps #Oncoalert
Excited to be part of this outstanding and important conference. Thanks @IEOufficiale for the opportunity to share highlights on #colorectalcancer!! #ASCO20 #CRC
#keynote177 #IDEA #RAPIDOtrial
@CCAlliance starting it off with #KeyNote177 for #MSI #mCRC patients in the 1st line.... Drs. Lieu & @marshalj23
#CRCLive #CRCSM #ASCO20
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