Pearson Lab

University of Chicago head and neck cancer lab doing research at the interface of computational methods, tumor biology, and clinical relevance. PI: Alex Pearson

[Pearson Lab @lab_pearson]

@kevinmboehm @theNCI Yesss! Congratulations 🎉. Well deserved. Can't wait to see the next generation of ideas.

[Pearson Lab @lab_pearson]

Great collaboration with @ErnstLengyel Lab led by Leo Donle and Michael Phillips.

[Pearson Lab @lab_pearson]

Excited to share our new #AI framework for harmonizing medical #foundationmodel *embeddings* across acquisition conditions and models🔬🩻💻.

We propose using paired data and a single global affine transformation per model, that we call FEATMAP

Preprint: https://t.co/dVv0fYTGWi

[Pearson Lab @lab_pearson]

We tried this in some useful contexts:
- Digital pathology (with scanner + foundation model harmonization)
- Brain MRI (1.5T ↔ 3T field-strength harmonization)

To do all this we generated almost 300M precision matched FM-based embeddings to test the alignment impact.

[UChicago Medicine Comprehensive Cancer Center @UCCancerCenter]

Congratulations to #SlideflowLabs, @UChicago spun out cancer pathology AI company on winning Rattan L. Khosa First Place Prize. #SlideflowLabs enables hospitals to run cancer biomarkers in-house with faster turnaround times. @lab_pearson @UChicagoPath
https://t.co/S7M1QE9Mfm

[Cancer Core Europe (CCE) @CancerCoreEU]

🤖 Join the Artificial Intelligence in Cancer Research Summer School 2025 hosted by @IstTumori- A pioneering event where cutting-edge technology meets life-saving medical innovation. More info ➡️ https://t.co/UmlxKpTCzK

[UChicago Medicine Comprehensive Cancer Center @UCCancerCenter]

At #ASCO25, Frederick Howard, MD, presents a poster showing high efficiency of AI models that accurately predicts treatment outcomes in breast cancer patients, offering a faster, more scalable alternative to traditional genomic testing.
@fredhow @lab_pearson @UChicagoHemOnc

[UChicago Medicine Comprehensive Cancer Center @UCCancerCenter]

From ambient dictation tools to FDA-approved diagnostics, #AI is transforming oncology!
At #ASCO25, Alexander Pearson, MD, PhD presents how AI is reshaping clinical cancer care—from research to bedside. @UChicagoMed @UChicagoHemOnc @lab_pearson

[Ari Rosenberg @AriRosenbergMD]

🧐Our DEPEND trial is out! Neoadjuvant nivo/chemo followed by response-stratified CRT in HPV-negative stage IVa/b HNSCC. @UCCancerCenter @UChicagoHemOnc @ajuloorimd @lab_pearson @HNCancerDoc @EIzumchenko @eevokes https://t.co/BHMPjA6NCw

[Pearson Lab @lab_pearson]

Jazzed to see our work describing *potential LLM use trends in @ASCO abstracts* as one of the @JCO_ASCO family top articles of 2024. Check out all the top articles here: https://t.co/ug48QHEHte. @fredhow @LGM_Biostats @JCOCCI_ASCO @UCCancerCenter @UChicagoBSD

[arsela prelaj @PrelajArsela]

The #callforabstracts for our annual AI for Oncology conference in @IstTumori (May 8-9, 2025) is open until Feb 3rd - https://t.co/gARV1MQbAL We really look forward to your submissions! And the top 3 will have the chance to present in front of a stellar lineup - don't miss it!

[Pearson Lab @lab_pearson]

@UCCancerCenter @fredhow @ScienceAdvances Check out @fredhow super cool work, including #VirtualBiopsies 🖥️💉predicting histology tumor growth patterns directly from #BreastCancer #MRI scans 🧲🪄 with #DeepLearning @UCCancerCenter @UChicagoBSD @UChicagoMed.

[Pearson Lab @lab_pearson]

Thanks so much @BasuLab1 @LovaSunMD @PennHeadandNeck! What a great opportunity to brainstorm science together.

[Devraj Basu, MD, PhD, FACS @BasuLab1]

It was a privilege to host @lab_pearson together with @LovaSunMD as part of our Head and Neck Cancer Center of Excellence lecture series and learn about progress toward AI-based discrimination of actionable states for cancer therapy.

[Nature Biotechnology @NatureBiotech]

Generative artificial intelligence for drug discovery: how the first AI-discovered and AI-designed drug progressed to phase 2 clinical testing
#behindthepaper https://t.co/SxB1FkkJeQ

[Akash Patnaik, MD, PhD, MMSc @AkashPatnaik7]

Honored to present our translational research at @TheVFoundation symposium. Thank you for the invtation and your support! @UCCancerCenter @UChicagoMed @UChicagoHemOnc @UofC @UChicagoCCB

[Pearson Lab @lab_pearson]

Very exciting things in the works @UChicagoHemOnc @UChicagoBSD #IYKYK

[William F Parker, MD, PhD @WF_Parker]

Incredibly excited to share our open-source Common Longitudinal ICU data Format (CLIF)! We hope CLIF will substantially improve the efficiency of critical illness research and evaluation of important ICU quality measures

Appreciate any and all feedback!

[James Dolezal @JamesDolezal]

🚀 Big news! Slideflow 3.0 is here! 🎉 We've revamped our licensing (now Apache-2.0) to make Slideflow more open & accessible. We've added 3 foundation models (Virchow, UNI, GigaPath), upgraded MIL, & much more. Check it out: https://t.co/IlxP0jEmLs #AI #Pathology #OpenSource

[Pearson Lab @lab_pearson]

Fantastic news!

[Evan Neczypor, MD @NezzSayz]

Thank you @woldloren! I am honored to receive this award from @ConquerCancerFd. I have been blessed with incredible mentorship on this project from the Applebaum lab @UChiPritzker @d_golden @lab_pearson & @spshubeck. Excited to present @ASCO!

https://t.co/EhUsjdY6jY @FutureDocs