Top Tweets for #LBA4
#LBA4 #SERENA6 trial 🚨
Camizestrant plus a CDK4/6 inhibitor for the treatment of emergent ESR1 estrogen receptor mutations during first-line endocrine-based therapy in HR + HER-2 Negative MBC patients
✅PFS at 2 years was 29.7% vs 5.4%, a hazard ratio of 0.52
✅ mPFS 16 months vs 9.2 months HR 0.44 CI 0.31-
⏳OS still immature
💡Time ti deterioration in gHRQL mTTD 23m vs 6.4m = better quality of life in Camizesterant group
✔️ Treatment discontinuation due to AE were low, 1.3% camizestrant and 1.9% Ai
⚠️Photopsia 20% ⬆️ vs 8% in other group but didn’t impact daily life
⚠️ESRm positive after 1 test 51% and 38% after 2-5 tests
@ASCO @OncoAlert #ASCO25
Of course the LAURA trial for EGFR unresectable Stages 3 diseases (although I have some concern regarding Asian population and OS results)
Ramalingan S et al. ASCO 2024 #LBA4
🔥#LBA4 LAURA: Osi after CRT in stage III EGFRm NSCLC
🎯Great discussion @LeciaSequist
✅Landscape of therapy
✅Crossover rate of Osi
✅Necessity of efficient MRD analysis to select pts who need longer Osi
✅Other driver+ stage III?
#ASCO24 #LCSM @OncoAlert @ASCO
🔥#LBA4 LAURA: Osi after CRT in stage III EGFRm NSCLC
🎙️@RamalingamMD
🎯PFS HR 0.16 (95%CI 0.10-0.24)
🎯OS HR 0.81 (95%CI 0.42-1.56, 20%)
🔥Urgent necessity‼️Biomarker testing regardless of stage
✅Primary: PFS
✅NCT03521154
#ASCO24 #LCSM @OncoAlert @ASCO
https://t.co/8sk2AVqlCW
🔥#LBA4 LAURA: Osi after CRT in stage III EGFRm NSCLC
🎙️@RamalingamMD
🎯PFS HR 0.16 (95%CI 0.10-0.24)
🎯OS HR 0.81 (95%CI 0.42-1.56, 20%)
🔥Urgent necessity‼️Biomarker testing regardless of stage
✅Primary: PFS
✅NCT03521154
#ASCO24 #LCSM @OncoAlert @ASCO
https://t.co/8sk2AVqlCW
⏰Starting in 1 hrs: 🔜1:00 PM CDT
🎯#ASCO24🔥"Lung" Plenary
✅#LBA3 Early palliative care via telehealth vs in person
🎙️Dr.Joseph Greer
✅#LBA4 LAURA: Osi after CRT in EGFRm
🎙️@RamalingamMD
✅#LBA5 ADRIATIC: Durva after CRT in LS-SCLC
🎙️@DavidRSpigel
#LCSM @OncoAlert @ASCO
⏰Starting in 7 hrs: TODAY🔜2:47 PM CDT
🎯#ASCO24🔥"Lung" Plenary
✅#LBA4 LAURA: Osi after CRT in EGFRm
🎙️@RamalingamMD
🎯PFS HR 0.16 (95%CI 0.10-0.24)
🎯OS HR 0.81 (95%CI 0.42-1.56), 20% maturity
✅Primary: PFS
✅NCT03521154
📰https://t.co/3xj29hFKAl
#LCSM @OncoAlert @ASCO
🆙BRAKING‼️ #ASCO24 "Lung" Plenary abstract
✅#LBA4 LAURA: Osi after CRT in EGFRm
🎙️@RamalingamMD
🎯PFS HR 0.16 (95%CI 0.10-0.24)
🎯OS HR 0.81 (95%CI 0.42-1.56), 20% maturity
✅Primary: PFS
✅NCT03521154
📰https://t.co/3xj29hFKAl
#LCSM @OncoAlert @ASCO
https://t.co/IvF5M7ZdHP
@PTarantinoMD @LungCancerRx @RManochakian @JackWestMD @lungoncdoc @FawziAbuRous @DevikaDasMD @IyengarPuneeth @NRGonc @UTSW_RadOnc @MSKCancerCenter @DFCI_BreastOnc @DavidRSpiegel @StephenVLiu @drshieldsmd @LaurenByersMD @teekayowo @sands_jacob @NarjustFlorezMD @KalinskyKevin @drsarahsam Sorry to break it to you, but #lcsm is #smallmolecule #TKI 👑💊 Another plenary, another year for Osimertinib #ASCO24..
1️⃣ LAURA: Osimertinib post-CRT in unresectable stage III EGFRm NSCLC. #LBA4 @RamalingamMD
➡️ Unresectable stage III EGFRm NSCLC
➡️ Endpoint: PFS
#KO 😉
⏰NOW OUT‼️ #ASCO24🔥Plenary Session #LCSM
✅#LBA3 Early palliative care via telehealth vs in person
🎙️Dr.Joseph Greer
✅#LBA4 LAURA: Osi after CRT in EGFRm
🎙️@RamalingamMD
✅#LBA5 ADRIATIC: Durva after CRT in ES-SCLC
🎙️@DavidRSpigel
@OncoAlert @ASCO
https://t.co/EfWoCfSUhR
🧐Hide and Seek🥇#ASCO24
🔥LAURA
🎯Osimertinib as consolidation after CRT in EGFRm Locally advanced NSCLC
https://t.co/Iq5PN73vLv
🔥ADRIATIC
🎯Durvalumab as consolidation after CRT in LS-SCLC
https://t.co/yNDZtrUWcw
#LCSM @OncoAlert @ASCO
#ASCO21 @ASCO Plenary #LBA4 : VISION trial just presented 👏👏177Lu-PSMA-617 is new SOC in “PSMA positive” mCRPC #prostatecancer with prior novel AR inhibitors + taxanes👉Reduces risk of progression by 60% & of death by 38% @Morr316 @oncoalert @PCF_Science @urotoday
The #OncoAlertTopTweet 🚨from Day1⃣ #ASCO21
Tweet @neerajaiims
@ASCO Plenary #LBA4 : VISION trial in “PSMA positive” mCRPC #prostatecancer with prior novel AR inhibitors+taxanes
index177Lu-PSMA-617 significantly improves OS & rPFS vs. SOC
Thanks, @weoncologists
#ASCO21 @ASCO Plenary #LBA4 : VISION trial in “PSMA positive” mCRPC #prostatecancer with prior novel AR inhibitors+taxanes👉177Lu-PSMA-617 (beta radiation) significantly improves OS & rPFS vs. SOC👇 Congrats @Morr316 #OliverSartor @oncoalert https://t.co/t9p7pQ9xBN @PCF_Science
#ASCO21 @ASCO Plenary #LBA4 : VISION trial in “PSMA positive” mCRPC #prostatecancer with prior novel AR inhibitors+taxanes👉177Lu-PSMA-617 (beta radiation) significantly improves OS & rPFS vs. SOC👇 Congrats @Morr316 #OliverSartor @oncoalert https://t.co/t9p7pQ9xBN @PCF_Science
#ASH20 #LBA4 Dr A. Hochhaus Ph3 #ASCEMBL #Asciminib vs #Bosutinib in patients with #CML after 2 or more TKIs. #STAMP = Specifically Target the #ABL1 #Myristoyl Pocket | #leusm #mpnsm #BCRABL
Really terrific commentary on #LBA4 by @michael_overman. Excellent explanation of curves crossing and agree this is practice-changing! What a relief to not subject pts to months of 1L chemo! #ASCO20
#ASCO19 Olaparib (Lynparza) improved PFS in patients with a germline #BRCA mutation and metastatic #pancreaticcancer (#LBA4, POLO trial.) STORY TO FOLLOW. ⚛️
<3 we're getting older! #LBA4 #Birthday #IndieUnite #TheaTO @theatreontario @TOPoetrySlam @obsidiantheatre https://t.co/mibbbny5pV
@LittleBlackAfro turns four today!! Damn. Thanks for the support everyone! @HYP_SLAM @StorefrontTO @HamiltonFringe
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