#MethylPred - Twitter Hashtag

about 3 years ago

@BichileT I would ask @TYoungstein as she’s my go to expert & the queen of #MAS. Fundamentally need to treat the #lupus so would give pulse #methylpred, oral pred, Cyclophosphamide & Rituximab But might use anakinra early on to reduce inflammation. Have used brief course CNI before

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

over 3 years ago

@arvindcanchi @nephondemand @sijiezheng @Lupusreference @raja_1980 @LupusAcademy @ISNWCN But agree the original @NIH papers deeply problematic & carried far too much weight for too long. But in their day game changing. & if patients non adherent /intolerant with oral meds the #CyP #MethylPred plus #Rituximab or #belimumab can be life saving. #lupus #nephritis 4/

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

almost 4 years ago

@hormone_doc @chriswincup My mantra! Almost every study that has used lower doses of #steroids, efficacy at least as good if not better and toxicity reduced. Max ##methylpred dose should be 500mg or less. #lupus #nephritis

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

almost 4 years ago

@chriswincup One of my all time favourite references! 100mg #methylpred x 3 = efficacy 1000mg x 3 doses. Lower doses AS effective. Demonstrated in 1987!! #steroids #lupus #lessismore

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Videsh Sookram @Sookie425

over 4 years ago · Trinidad and Tobago

Nothing like an exciting call when you have to open pharmacy.. #Methylpred

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

about 5 years ago

@divyaa24 @BradRovin @hannahksb @doc_wilson3 @1mariecondon #Aurora trial showed how to taper rapidly.I like Brad’s idea of #obinituzumab #Methylpred & #MMF & no oral steroids BUT new worry -poor anti-#COVID19 ab after #CovidVaccine if B cell deplete & obi depletes for a v long time - problem if need regular boosters. #lupus #nephritis 2/

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

about 5 years ago

@divyaa24 @BradRovin One day! We only give #methylpred 500mg x 2 & NO #steroid if not on. Now I’m well, we should finally get out our long term data on our 20 year #lupus #nephritis cohort. Majority of 100+ #rituxilup #patients remain off steroids after years @hannahksb @doc_wilson3 @1mariecondon 1/

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Dr. Sahab! @Dr_Saaab

over 5 years ago

VERIFIED. #DELHI. #DEXAMETHASONE. #METHYLPRED. #FABIFLU. #BEVACIZUMAB. Ambey Medicine Corner - Safdarjung Hospital, for Dexamethasone 4mg & 8mg, Methyprednisolone - MEP4, Fabiflu. Doctor's Prescription required for all medication. #+919910160011.

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Nick Mark MD

@nickmmark

almost 6 years ago

These studies differ in steroid (#hydrocortisone, #dexamethasone, #methylpred) & dose, population enrolled (ICU vs wards, intubated vs not), & primary endpoints (mortality, MV duration, organ failure, etc) All were well done methodologically though several were stopped early. 5/

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Sethina Watson @morefluids

over 6 years ago

For the latest #trials on #COVID19 #SARSCoV2 - excellent summary of drugs/trials in this thread from @GongGasGirl recap of @AAGBI #webinar #stemcells #awakeproning #monoclonals #interferons #methylpred #ConvalescentPlasma #Hydroxycloroquine

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

about 7 years ago

@NephRodby @CaptainKidney79 @GlassockJ @kdjhaveri @aishaikh @poyanmehr @hswapnil @VelezNephHepato @fervenzafernan1 @LaurenceHBeckJ1 @Rush_Nephrology Absolutely. Two trials - https://t.co/ykR6uzUJzt 100mg=1000mg in #SLE #lupus https://t.co/PqTJhxlDQL lower (still high!) #methylpred as good and less toxic. #lessismore #steroid

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

about 7 years ago

@tulunsokit @GlassockJ @KavGul6 And agree with @NephRodby it’s a very nasty #biopsy with necrosis and I imagine losing function quickly. We’d almost certainly use #modified #eurolupus - much <#steroid (2-3 x 500mg #methylpred, 0.5mg/kg/d oral pred) & likely #Rituximab. And #ovarian #protection & #HCQ 2/

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

over 7 years ago

@stephenmcadoo @lastwalsh And the answers to those questions are? And why 3g #methylpred ? But regardless, huge congrats on delivering such a huge trial in a rare disease 👏🏻👏🏻👏🏻 Comiserations to @Profcpusey #Vasculitis2019

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

over 7 years ago

@RealDr_Pepper You’ll have to buy @Profcpusey a lot of whisky to get him through this!!! Anyone challenging the 3g #methylpred everyone got? Seems a retrograde step from #MEPEX? #PexiVAS #Vasculitis2019

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

about 8 years ago

@Dr_Beale_ @arvindcanchi @akshayakeerti @dr_nbbbb Don’t disagree - my first line for #lupus #nephritis would be #rituximab #methylpred (500mg x/) and #MMF and NO oral steroid but expensive. Am assuming patient in India & may be unaffordable.

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Prof Liz B 🇬🇧🇮🇱🇺🇦🇵🇸

@kidneydoc101

about 8 years ago

Relevant to so many areas of #nephrology #membranous #lupus #Vasculitis #IgA etc. #methylpred pulses should prob 500mg IV or less (can cite you why) in non #CNS disease, oral pred max 0.5mg/kg/d, max 60mg. We need trials - dose, duration, taper etc. #ERAEDTA18 @AuriniaPharma

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