Top Tweets for #MotorNeurons
Recently published work lead by the very talented @DVillarroelC. Lots of work has gone in to this and I have enjoyed seeing this story develop over the years. Congrats to all! @SchiavoMNPlab @FrattaLab @Jobby1kanobi #axonaltransport #Rab7 #motorneurons #TBK1
Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7. https://t.co/NPV4DXxRbn
#A novel therapeutic molecule targets and removes misfolded SOD1 proteins from #NerveCells, slowing symptom progression and protecting #MotorNeurons in models of motor neuron disease. @uow @NatureComms https://t.co/pgmVUufUhg https://t.co/X1kmWfdLkr
#Als targets #MotorNeurons due to their constant, high burden of protein and organelle degradation. This intrinsic stress may explain their selective vulnerability and the disease’s relentless progression. @NatureComms https://t.co/Bt2OXztIql https://t.co/b6VozMqEhI
Research Article by @helio_cabral et al. (@_frankyblack_ @Dr_J_G_Inglis @unibs_official @uarizona) Adaptations in common #synapticinputs to #spinal #motorneurons during grasping versus a less functional hand task ✋🤏🫳
https://t.co/1OpvT2HTGd
A British woman suffering from motor neuron disease who lost her ability to speak is once again talking in her own voice thanks to artificial intelligence and a barely audible… https://t.co/BKUrq4AbhS #AI #ArtificialIntelligence #VoiceRestoration #Technology #MotorNeurons
ALS Mutation Linked to Stress Response Points to Targeted Therapies
Dampening the integrated #stressresponse (IRS) in motor neurons may be a valid therapeutic approach in patients with an inherited form of ALS
@cwru
#ALS #motorneurons
https://t.co/0tfdtygS7L
Organ-Chip ALS Model Uses Patient iPSCs to Uncover Early Disease Progression
An iPSC-based ALS-chip model was developed that mimicked early disease progression, revealing altered glutamate signaling in #motorneurons
@CedarsSinai #iPSCs #ALS
https://t.co/BgNO8wP5AG
Join Us for the Memory Decoding Journal Club! "Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons" https://t.co/BK7jb2lpcp #Neuroscience #MemoryResearch #MotorNeurons #JournalClub #BrainScience #Carboncopies #AspirationalNeuroscience
Join Us for the Memory Decoding Journal Club! - Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons
https://t.co/bei9gKPCFd... #Neuroscience #MemoryResearch #MotorNeurons #JournalClub #BrainScience #Carboncopies #AspirationalNeuroscience
It's over 150 years since #SMA was first described, but now for the first time we have carefully and accurately quantified the fundamental loss of #MotorNeurons upon which the disease is based: https://t.co/smeBU3l5bD @SMAEurope @SMA_UK_ @CureSMA @AbdnLifeScience @ParsonLab
📃Postsynaptic potentials of soleus #MotorNeurons produced by #TransspinalStimulation: a human single-motor unit study (Nilgün Yildiz et al.)
https://t.co/FnS0su9gFN
#PostsynapticPotentials #MotorUnits #TranscutaneousSpinalCordStimulation
🧠🧠Understanding the Difference Between Upper Motor Neuron Lesions (UMNL) and Lower Motor Neuron Lesions (LMNL)🧠🧠
#Neurology #UMNLesion #LMNLesion #MotorNeurons #MuscleHealth #NeurologicalDisorders #HealthAwareness #StayInformed
BREAKING COVID-19 News! SARS-CoV-2 Also Targets Human Motor Neurons! Expect More Neuromuscular Issues In Post COVID Phase!
https://t.co/hGZcDs9EJG
#COVID19 #News #BreakingNews #SARSCoV2 #USA #America #UnitedStates #MotorNeurons #London #Europe #Germany #France #Australia #India
A new NorthwesternMedicine study has found that modulating the activity of a kinase in #MotorNeurons may help mitigate #MitochondrialDefects and other symptoms of spinal muscular atrophy, offering a new therapeutic avenue for the devastating disease, per @PNASNews.
Finally it's #FluorescenceFriday again!
Today with iPSC-derived motor neurons stained for MAP2 (yellow), TOMM20 (magenta), and NucBlue (cyan). @zeiss_micro
📷 @klarametzner
#WinnerLab #stemcells #motorneurons #staining
📣 Don't miss this
GM1 ganglioside exerts protective effects against glutamate-excitotoxicity via its oligosaccharide in wild-type and amyotrophic lateral sclerosis motor neurons
🔓https://t.co/XnCKZXcWFU
#MotorNeurons #Glycosphingolipids #Neurodegeneration
Many thanks to @ArielJLevine for organizing a wonderful celebration of motor systems/Michael O’Donovan for the annual #preSfNmotorsymposium I learned so much - including how hard it was to make physiologically relevant solution for motor preparations! #SfN2023 #SfN #motorneurons
Congratulations to @Jobby1kanobi on leading this huge and exciting body of work on the many roles of #BDNF in regulating #transcription, the #cytoskeleton and #regeneration in #iPSC #motorneurons! A must read!
To the axon, RNA regulation, neurotrophin, and cytoskeleton nerds and nerdettes out there:
Ta-dah!! :)
(Summary thread coming soon).
BDNF controls phosphorylation and transcriptional networks governing cytoskeleton organization and axonal regeneration https://t.co/xz8mHtCS0k
Amyotrophic lateral sclerosis is a fatal and rapidly progressing neurodegenerative disease that affects motor neurons.
#sclerosis #motorneurons #motornerves #immunology #Bcells #antibodies #mutant #myelin #axon #celldeath #immunesystem #multiplesclerosis
Jason Villagomez & me (snapper extraordinaire) presenting @sophionbio poster on #ionchannel recordings from #iPSC derived #motorneurons from #ALS & #SMA patients on #APC #Qube & #QPatch.
Also our latest 8-recording site #QPatchCompact.
#ephys #electrophysiology
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