Top Tweets for #OLPASIRAN
LIPOPROTEIN a & CHRONIC KIDNEY DISEASE
⬆️Lp(a) as renal function declines
⬆️Lp(a) contributes to the excess CV burden and residual risk
👉🏻Th causal role of Lp(a) in CKD-related cardiovascular disease remains incompletely defined
DOI: 10.1159/000553534
#pelacarsen #olpasiran
Lp(a) AWARENESS DAY
✅Biomarker that further predicts CV risk
✅Once in life recommended measurement
✅Repeat after menopause
✅Treatment might be available soon
#knowyourlpa #lpainsights #pelacarsen #olpasiran #lepodisiran #muvalaplin #zerlasiran #acc26 #smalllpa #lifeiswhy
$AMGN $ARWR #Olpasiran
Watch @DrM_ODonoghue, @BrighamWomens present extensive #olpasiran data from the Phase 2 OCEAN(a)-DOSE trial, and discuss progress with the ongoing Phase 3 OCEAN(a)-OUTCOMES and OCEAN(a)-PreEvent trials at the 2nd expert meeting of the @LpaForum > https://t.co/3kMC6jkEAA
#Lpa #CVD
New data from the OCEAN(a) DOSE - TIMI 67 trial indicates that siRNA #olpasiran reduces Lp(a) irrespective of apo(a) isoform size and affects both isoforms equally. @DrM_ODonoghue #AHA25
Why does interference of apo(a) synthesis with #olpasiran also lead to a net reduction in apoB particles? Read more online now @JAMACardio @DrM_ODonoghue @AndreZimerman
https://t.co/kHovQ9lUTG
LIPOPROTEIN A REVIEW
✍️Factors Associated With⬆️Lipoprotein(a)
✍️Lipoprotein(a) and ASCVD Risk
✍️Guideline Recommendations for Lipoprotein(a) Testing
✍️Management of High Lipoprotein(a)
https://t.co/DsMesyKk2a
#cardioX #Olpasiran #pelacarsen #lepodisiran #muvalaplin #lpainsights
Lipoprotein(a) as a Pharmacological Target: Premises, Promises, and Prospects 👉🏻 https://t.co/PCRCOeIiiA @CircAHA #LEPODISIRAN ACCLAIM-Lp(a) @EliLillyandCo #OLPASIRAN OCEAN(a)-Outcomes Trial @Amgen #PELACARSEN Lp(a)HORIZON @Novartis @ValleAlfonso @jlopezmir
PCSK9 INHIBITOR WAR
✍️How Does Inclisiran Fit in with Current Monoclonal Antibody Inhibitor Therapy?
✍️Reasons for a Novel Agent in a Crowded Therapeutic Field
✍️Deserved (deep) reading https://t.co/0pG16otbvu
#PCSK9 #bempedoic #pelacarsen #olpasiran #lerodalcibep #Volanesorsen
$ARWR $AMGN #RNAi #SiRNA $7.9 billion NPV for #Olpasiran #AMG890 #Lipoprotein #Lipoproteina #LPa #SilenceTheGene #GeneSilencing #Phase3 @ArrowheadPharma @BertrandBio
Most valuable R&D project by NPV (consensus forecast)
Top 4 all obesity: $NOVOB CagriSema NPV likely outdated as well, since many analyst have downgraded their PT for Novo in recent days post REDEFINE 1, then $LLY reta & orfo, and $AMGN mariTide
Also 2 FcRn's from $IMVT (I guess ranked on the 2 combined)
Then $MLTX Il-17A/F nanobody soleno, followed by $AMGN Lp(a) siRNA, #Akeso $SMMT ivo PD-1 x VEGF, and $MRNA $MRK PCV MRNA-4157
Zerlasiran, a small-interfering RNA, reduced time-averaged lipoprotein(a) concentrations by more than 80% during 36 weeks of treatment in patients with atherosclerotic cardiovascular disease.
https://t.co/8W9UmoUu6S
Por otro lado, #olpasiran un #ARNinterferencia, nos ha mostrado en el OCEAN[a]-DOSE trial, reducciones de #Lpa del 70.5% (10-mg), 97.4% (75-mg), 101.1% (225-mg) cada 12 semanas, quedando pendiente efectos a nivel #cardiovascular en ensayos fase-III
#LpaInsight
![gomezdelgadoFJ's tweet photo. Por otro lado, #olpasiran un #ARNinterferencia, nos ha mostrado en el OCEAN[a]-DOSE trial, reducciones de #Lpa del 70.5% (10-mg), 97.4% (75-mg), 101.1% (225-mg) cada 12 semanas, quedando pendiente efectos a nivel #cardiovascular en ensayos fase-III
#LpaInsight https://t.co/wMwDEOfuU9](https://pbs.twimg.com/media/Gek8yEKWoAAshOA.jpg)
Catching up on some reading and it is exciting to see our editorial with @JSpitz_MD on #olpasiran in print in @JACCJournals! @HeartPlano @InovaHealth
Coverage of @DrM_ODonoghue's paper on the extended benefits of #olpasiran in the OCEAN(a)-Dose trial in @medicaldialogs
https://t.co/NQWFlC9Czi
📍The Off-Treatment Effects of Olpasiran
on Lipoprotein(a) Lowering
#OCEAN(a)-DOSE Extension Period
👥 276
⏰86 weeks
👉mean % change from baseline in Lp(a) was 76.2%➡️53.0%➡️44.0%➡️27.9% at 60, 72, 84, and 96 weeks, respectively
👉The respective off-treatment changes in Lp(a) for the 225 mg Q12W dose were 84.4%➡️61.6%➡️52.2%➡️36.4%
📁 https://t.co/DfoYiXY1B0
Dr. Belardo and I discuss the new advances in treating Lp(a), one of which #olpasiran reduces levels one year after drug discontinuation in the OCEAN(a)-DOSE trial.
The Off-Treatment Effects of #Olpasiran on Lipoprotein(a) Lowering: OCEAN(a)-DOSE Extension Period Results. https://t.co/xTNXVCxEXA
In summary, this new publication by @DrM_ODonoghue et al tells us that about 1 year after the last dose of #olpasiran 225 mg, Lp(a) levels didn't return to pretreatment values and were still 40% - 50% lower than in baseline. Seems promising, looking forward to outcome studies!
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