Top Tweets for #PEXIVAS
ANCA-associated glomerulonephritis: New #PEXIVAS study data show that plasma exchange (PLEX) significantly improves early kidney function (+41% recovery after 4 weeks). No difference in response based on steroid dosage. 👉 https://t.co/QbLHcpswuk #KidneyHealth
#PEXIVAS Trial #post-hoc Analysis
🌟✨ Important Findings from the #PEXIVAS Trial on ANCA-Associated Vasculitis! ✨🌟
Over a 12-month study involving **691 patients** with significant kidney involvement, we explored the impact of **Plasmapheresis (PLEX)** on kidney function.
🚀 **eGFR Improvements**: Remarkable increases in kidney function observed at weeks 2 (4.8 ml/min), 4 (4.2 ml/min), and 8 (4.3 ml/min) for those receiving PLEX compared to no PLEX. 📈
🔍 **Early Recovery**: At week 4, kidney function recovery stood at **32.7%** for the PLEX group vs. **23.0%** in the control group (Relative Risk: **1.41**) - a significant advancement!
🌟 **Long-Term Benefits**: Sustained improvements evident at weeks 26 (RR: 1.09) and crucially at 52 weeks (RR: 1.16), showcasing the lasting impact of PLEX!
🧬 **PR3-ANCA vs. MPO-ANCA**: Patients with **PR3-ANCA** had better recovery outcomes across all time points, highlighting the importance of serotype in treatment success (week 4 RR: **1.39**).
In conclusion, the #PEXIVAS trial underscores the substantial early and long-term benefits of PLEX in enhancing kidney function for AAV patients, particularly those with PR3-ANCA!
➡️ Dive deeper into the findings: DOI: 10.1016/j.kint.2025.01.002
#KidneyHealth #ANCA #Vasculitis #ClinicalResearch #HealthScience #MedicalBreakthroughs #MedTwitter #RheumTwitter
Without having the kidney biopsy, we don’t know which patients had active inflammation.. This is a huge limitation #PEXIVAS #Nephtwitter
Someone just said “I’m ashamed” “We need more randomized trials on apheresis”
📄 Hémorragie intra-alvéolaire chez des patients avec #vascularites associées aux #ANCA : résultats essai randomisé contrôlé #PEXIVAS 👤 Résumé par Drs @BaptisteChevet @Kev_Chevalier Divi CORNEC & Bérengère MOLINA ➡️ https://t.co/VNSC7t0dlP #maladiesrares #FAI2Ralupourvous #fsmr
#Editor’s #Choice
@MatsJunek
Who #relapses in
#ANCA #vasculitis
In #Pexivas trial
#Renal #failure may be protective from relapses.
Seems to be the case in renal #lupus #GN too~my opinion
?Why 🤷
#EULAR2024 #EULARBEST @ARD_BMJ
@RheumNow @eular_org @ACR_Journals
In this analysis of the #PEXIVAS study, there was no credible effect of plasma exchange on survival or ventilator-free days
@LynnFussner
@lastwalsh
@OSUPCCM_Fellows
🔗 https://t.co/jEXP9f5Gly
Outcomes of DAH in #AAV (post-hoc #PEXIVAS):
1️⃣ 26% death by 3 months when severe DAH (vs <5% in non severe or no DAH), mostly within 1st month
2️⃣ no effect of PLEX nor GC regimen on 1 year mortality, whether in any DAH, not severe or severe DAH groups (low numbers). @LynnFussner
@WLASZ @drmohansai @iamnephrologist @odlerb @Ting2li @DuvuruG Thanks for including me in this discussion!
Our pre-specified post hoc analysis of patients with DAH due to AAV in #PEXIVAS (just published, open access next month) found no effect of PLEX on outcomes, including vent-free days.
https://t.co/sVE0gvbEDU
Brilliant presentation @odlerb !
How does plasma exchange affect early renal improvement in AAV patients.
Tailored treatment is the best approach. Looking forward to the publication!
#VasculitisBCN2024
#vasculitis #pexivas
@vascuk @IrishVasculitis @Vasculitis_NL @_ERNRITA
Relapse in AAV (post-hoc #PEXIVAS):
1️⃣ 92% achieved remission, with 23% relapsing (median follow-up 3 years)
2️⃣ PLEX & low dose steroids: not associated with relapses
3️⃣ PR3-ANCA, non-DAH lung involvement: ↑ relapse risk
4️⃣ severe kidney disease, oral CYC: ↓ relapse risk
PEXIVAS subanalysis: neither PLEX nor the use of reduced-dose glucocorticoids was associated with the risk of disease relapses... Another safety point to reinforce the use of reduced-dose glucocorticoids in #ANCAvasculitis
https://t.co/cmH8m18BPH
From the #Transfusion Evidence Round-Up #WorldKidneyDay2024
#Plasmaexchange and #glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: #PEXIVAS non-inferiority factorial RCT
by Jayne et al.
https://t.co/ICfBVG88kh
Thanks for the opportunity to work on this, @lastwalsh!
With the inclusion of participants with DAH on vent, #PEXIVAS provides valuable insights into this population…and all the work that is still needed.
@OSUPCCM_Fellows @OhioStateDHLRI @ATSBlueEditor @VasculitisFound
#PEXIVAS’s lesser known little brother PEXIHAIR demonstrates non-inferiority for silkiness
To Reduce Rapidly or Not? 🤯
#PEXIVAS vs Standard #Steroid taper
Every patient should be Individualised
with regards to their steroid taper ⬇️
Always is not always the right answer especially in ANCA #Vasculitis
(Mostly the wrong one)
#Rheumatology👇
319 pts with severe #GPA were studied with #steroid lower dose #Pexivas regimen studied Rx differences including Rx with #immune #suppressives and various doses of #steroids in French #vasculitis group. abst0725 @ACRheum @RheumNow #ACRbest Reduced #prednisone dose BAD esp w #RTX
#isfa2023 Andreas Kronbichler @AKronbichler presenting data on plasma exchange #PLEX in AAV - post #Pexivas - Pexivas is not the end! I completely agree.
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