Top Tweets for #Replisome
CMG helicase disassembly is essential and driven by two pathways in budding yeast
Karim Labib and colleagues show that Pif1-family helicases mediate an ancestral pathway for ‘old’ #replisome disassembly during the subsequent S-phase
https://t.co/pCwkNuzxgB
How do physiological DNA secondary structures affect genome stability?
In vitro reconstitution by @CosterLab @ICR_London shows physiological #G4 or iM #quadruplex formed during #replication stall eukaryotic #replisome by inhibiting leading strand synthesis
https://t.co/f5khlGObR8
I love to #draw! Here a cover art that I made for our paper (👉🏻 https://t.co/PwwL87eAIZ): "the DNA is like the narrow streets of small Italian villages: only one machine at a time! #Sen1 (👮♂️) removes #RNAPII (🛵) to avoid collisions with the #replisome (🐝🚗)".
"The Interplay of #Cohesin and the #Replisome at Processive and Stressed #DNA #ReplicationForks" from van Schie and de Lange.
#cellsmdpi #molecularbiology #cellbiology
Full text: https://t.co/E8B9TSC8Qj
#NewChapter #replisome #SARSCoV2
Los invitamos a leer nuestro 𝗻𝘂𝗲𝘃𝗼 𝗰𝗮𝗽𝗶́𝘁𝘂𝗹𝗼 sobre la biología estructural del replisoma del #SARSCoV2: un complejo molecular que le ayuda al coronavirus a replicar su material genético.
Link: https://t.co/ty3BXCsP5b
It was great working with everyone involved with this project, especially @mljones1993 here at the @MRC_LMB, and our collaborator @TDDeego at the MRC HGU in Edinburgh.
@Nature #Replisome #DNA #Replication #CryoEM
(2/2)
🔓 #OA
TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans
➡️https://t.co/fMe4MUiopN
@UoDLifeSciences @mrcppu @YisuiXia Ryo Fujisawa @TDDeego Dr Remi Sonneville Prof Karim Labib
#DNAReplication #CDC48 #Replisome
🔓 #OpenAccess
The fate of two unstoppable trains after arriving destination: Replisome disassembly during DNA replication termination
➡️https://t.co/0M34DiPr6r
@UoDLifeSciences @mrcppu @YisuiXia
#Ubiquitylation #DNAReplication #Replisome
Species-specific fine-tuning of #replication termination: Karim Labib, Remi Sonneville & coworkers @mrcppu show role of #replisome-associated TIMELESS-TIPIN complex and #p97 adaptor UBXN-3 in ubiquitination and disassembly of CMG helicase
https://t.co/mpb9IEGhSv
#Researchers @RockefellerUniv are uncovering remarkable insights into #DNA replication, the process that underpins how #genetic material is copied and reproduced such that #life on #earth can grow. Learn more: https://t.co/HCJhO7wZFv
#replisome #proteins #celldivision #scicomm
(1/2) We show that in human cells, #replisome disassembly is continuously required for efficient DNA replication by recycling key replisome components back into the soluble compartment.
Failure to disassemble replisomes after LRR1 loss suppresses #DNA #replication by blocking the recycling of replication factors. Image from a study by Yilin Fan, @MeyerTeruelLabs and colleagues.
https://t.co/oyHjlMraSo
#Biochemistry #Cellcycle #Celldivision
Excited about this preprint coming out from @Megan_Behrmann @HimashaMPerera. Several years of work establishing ways to do in vivo biochemistry of #DNAreplication #DNArepair. This is just a start! #replisome #coupling
Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness https://t.co/GIePc3JXRr #bioRxiv
New #openaccess research from @IshinoYoshizumi and colleagues: Two conformations of #DNA polymerase D-#PCNA-DNA, an archaeal #replisome complex, revealed by cryo-electron microscopy
Read it here: https://t.co/E2t8EbptyX
#Researchers @RockefellerUniv are uncovering remarkable insights into #DNA replication, the process that underpins how #genetic material is copied and reproduced such that #life on #earth can grow. Read more: https://t.co/gu6SzLMeEU #replisome #proteins #celldivision #scicomm
Our very own @ThomasRetzer94 presenting a poster @interactmunich about #singlemolecule studies of #replisome coping with #topological barriers
Binding to histones
Pol α helps to maintain
Silent chromatin
#ChromatinHaiku #Replisome
paper: https://t.co/9shWVZmFXV
author tweet: https://t.co/ClmliNMwXw
We've got a new paper out:
Histone H2A‐H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin.
https://t.co/cfeZK5pQqk
@embojournal
Thanks Cecile/Karim for the great collaboration!
Chromatin, here we come...
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