Yisui Xia 夏乙燧

Postdoc @ Karim Labib' Lab / UoD / C. elegans/ DNA replication / Leeds Utd fan / 中国🇨🇳重庆🌶

[Yisui Xia 夏乙燧 @YisuiXia]

Glad to share our KL lab recent work on @ScienceMagazine about DONSON orthologues are essential for CMG assembly during initiation in C. elegans🪱, by a nice collaboration between us @mrcppu, @Yeeles_Lab @MRC_LMB, Ye and Constance @UoDLifeSciences
https://t.co/qFpykA5ogV

[Yisui Xia 夏乙燧 @YisuiXia]

Absolutely bias. Imaging if a Germany player hold the photo of Nazis. What will you guys do? Hypocrisy!

[Brighton & Hove Albion Academy @BHAFC_Academy]

The club sincerely apologises for any offence caused in China by a recent post about our Academy’s participation in the Premier League Christmas Truce Tournament.

We hugely value our fans in China and had no intention of causing any offence.

[Yisui Xia 夏乙燧 @YisuiXia]

Last day in Dundee. Sweet 9 years.
Moving on, a step forward from postdoc to young PI.

[altmeyerlab @altmeyerlab]

Sharing our latest work @UZH_en tracking DNA damage inheritance by Live+QIBC https://t.co/pN5Ivt8DIV. Huge congrats to @APanagopoulos_, M. Stout and all co-authors for this tour de force! Beautifully summarized by @S_J_Aitken and E. Reilly @NatureNV https://t.co/9IVexti382.

[Duderstadt_lab @DuderstadtLab]

🚨New preprint🚨We developed a transverse flow imaging approach to directly visualize bacterial replisomes challenged by topological barriers and discovered a fast rotational mode of replisome operation. Fantastic work by Thomas Retzer and Hamdan Lab! https://t.co/p8YYBlVtFN

[Lucas Farnung @LucasFarnung]

🔬 New from the Farnung Lab: We have established a fully in vitro reconstituted chromatin replication system and we report the first cryo-EM snapshots of the human replisome engaging nucleosomes. 🧬✨https://t.co/Ox7gJYtUyL

[Hana Sedlackova @HanaSedlackova1]

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! https://t.co/N643U0oS1M

[Zha Lab @zha_lab]

Thank Dr. Chen for a great talk. Dr. Sophie Polo will join Social DNAing this week to share a story on the connection between epigenome and DNA damage response. Please sign up at https://t.co/XaGM9Lt62q

[Costa Lab @CostaLabCrick]

How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA?

Find the answer in our latest article
https://t.co/OKrGwsCNr8

Congratulations to Agata Butryn, who spearheaded the entire project, Contributions from @GreiweJulia in the early days.

🎉❄️🔬🧬

[James Dewar @JamesMDewar]

In our latest preprint we analyzed how abasic (AP) sites affect DNA replication:
- AP sites stall DNA synthesis ⛓️‍💥
- Leading APs stall replisomes but lagging APs don’t 🛑/✅
- TLS is crucial for bypass of both leading and lagging strand AP sites 🛠️🧬
https://t.co/to6d9i6Dn1

[Zha Lab @zha_lab]

Happy New Year from Social DNAing to you all! Let us roll with 2025!

[Hana Sedlackova @HanaSedlackova1]

📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: https://t.co/296kJoJh1M

[Bleichert Lab @BleichertLab]

Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉

Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways.

Read more here: https://t.co/bPT5Y4uPkR

[Johannes Walter @FrogWalterLab]

Check out latest from the Walter-Pellman collaboration, revealing how the replisome is remodeled in mitosis to allow CMG eviction, which we propose minimizes fallout from under-replication.
https://t.co/n0OaywrcGU

[Juntao Yu @just_a_fly_guy]

The two papers from the Chen Lab describing the discovery of cGAS and cGAMP are among the most elegant biochemical studies I have ever read. Congratulations to Dr. Zhijian "James" Chen and the Chen Lab on this well-deserved honor. A truly inspiring breakthrough!

[Hana Sedlackova @HanaSedlackova1]

📢For all HaloTag lovers💙💚❤💜🤍 we developed a new cell-permeable Biotin-HaloTag ligand enabling rapid protein labeling in living cells and efficient streptavidin pull-down. We hope you enjoy the reading and find some inspiration🙌 https://t.co/LIbONhRKde

[Steven Banik @StevenMBanik]

Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH @StanfordUChem https://t.co/XQFwRmnfaX

[Tom Deegan @TDDeego]

What a fantastic few days at UK DNA replication 2024 - thanks @BiochemSoc for organising such a great meeting. Hope to see you all in Edinburgh in two years time 🏴󠁧󠁢󠁳󠁣󠁴󠁿

[Google DeepMind @GoogleDeepMind]

We’re presenting AlphaProteo: an AI system for designing novel proteins that bind more successfully to target molecules. 🧬

It could help scientists better understand how biological systems function, save time in research, advance drug design and more. 🧵 https://t.co/lx35RvplFr

[Yeeles Lab @Yeeles_Lab]

🚨📣 Excited to share our latest work investigating how the replisome responds to topoisomerase-DNA crosslinks 🧬🔬

https://t.co/9ujCs1k8g5

Fantastic work from @rosewesthorpe and @JohannJRoske 🍄🍄🍄🍄

[Johannes Walter @FrogWalterLab]

Thrilled to share our new finding that the DUB USP37 suppresses rogue ubiquitylation and disassembly of stressed replisomes by TRAIP. Fantastic collaboration between Olga Kochenova in my lab and Giusi D’Alessandro in Steve Jackson’s lab! Read all about it: https://t.co/ELz9S8qHAi