Top Tweets for #ZFPs
Other than Sangamo, no one can really make good ZFNs (zinc-finger nuclease). $SGMO @SangamoTx
@chromamedicine
@WhiteheadInst
@davidrliu
@JswLab
#ZFP #ZFPs #epigenetic #Genetherapy #ZFN #ZFNs
Other than Sangamo, no one can really make good ZFNs (zinc-finger nuclease). $SGMO @SangamoTx @chromamedicine @WhiteheadInst @davidrliu @JswLab #ZFP #ZFPs #epigenetic #Genetherapy #ZFN #ZFNs https://t.co/x6I3vh2smI
https://t.co/0M0A0zCS6B
@politicalbeauty Soso, interessiert anscheinend nicht allzu viele Menschen eure Propaganda.
#Stasi - Ableger #ZfPS
Nature Paper showing $SGMO Epigenetic Editing Programs
says #ZFPs may prove
more clinically relevant than CRISPR based on a smaller
size, mode of DNA binding and
more favourable immunogenic profile with #first clinical epigenetic editing trial indeed exploiting the #ZFP #platform
Dysregulated gene expression is associated with nearly #all human #disease and can be mediated by epigenetic modifications
$SGMO #Epigenetic #editing aims to reprogramme gene expression by rewriting epigenetic signatures, without editing of the genome.
https://t.co/hSQCnh3Buz
We demonstrate that CAG-targeting $SGMO #ZFPs reduce HTT1a levels, making them the #only HD therapeutic to allele-selectively lower mHTT, reduce HTT1a levels, and block instability.
#epigenetic #editing techniques such as #ZFPs have great #advantages as therapies for #HD
$QURE
$SGMO University of Washington says
#Huntingtons
"We found that treatment with #zinc #finger transcriptional #repressors basically totally #blocked the progression of instability, which makes me very anxious to get a #ZFP trial going in HD"
https://t.co/Pcphjp6wly
re $QURE
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#Avantis #ZFPs #Perps #RWAs #Wallchain
Suppression of #Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
$SGMO
"we believe that #epigenetic #editing techniques such as #ZFPs have great theoretical #advantages as therapies for HD "
https://t.co/DcryANPRJg
$SGMO we explore the diversity of zinc-finger containing proteins (#ZFPs) in the human genome for their capacity to bind DNA, RNA or both. We discovered specificity for the RNA-binding ZFPs and found they regulate many aspects of RNA
https://t.co/MdEtcvNtsb
Online Now: C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes https://t.co/bzeJa4EDKM
@zeusPharma @BowTiedBiotech @EdwinNNeumann @JswLab @WhiteheadInst @SangamoTx @chromamedicine Yes but differently however both using @SangamoTx #ZFPs. $SGMO also seems closer to clinic as having #capsid for iV delivery crossing #BBB (monkey data) wich might crucial in highly infectious desease. Weissman could go #Intrathecal route. RESURRECTION of Zinc Finger Proteins
@BowTiedBiotech It's a beautiful editorial highlighting the @EdwinNNeumann paper by @JswLab @WhiteheadInst using @SangamoTx $sgmo #zfp licensed to @chromamedicine https://t.co/DbW0ShlSBf #epigenetic #genetherapy #zfps #zfn #genomicmedicine
A CHARMed collaboration created a potent therapy candidate for fatal prion diseases:
Brainwide silencing of #prion protein by #AAV-mediated delivery of an engineered compact epigenetic editor. $SGMO @SangamoTx
https://t.co/Ht8tp5qTWc
https://t.co/X0lXRTqIu2
Showing Prions and #CRISPR-#Cas9 the Zinc-Finger:
#Epigenetic #Genetherapy even in the #CNS is closer to the #clinic as thought! https://t.co/rHlGDYrUSs
@JswLab researchers replaced Cas9 with a much smaller zinc finger protein... @WhiteheadInst @chromamedicine @SangamoTx #ZFPs
Other than Sangamo, no one can really make good ZFNs (zinc-finger nuclease). $SGMO @SangamoTx @chromamedicine @WhiteheadInst @davidrliu @JswLab #ZFP #ZFPs #epigenetic #Genetherapy #ZFN #ZFNs https://t.co/x6I3vh2smI
@GamalielBaer @RNAiAnalyst Correct and additional the highly immunogenic properties of #Cas9 compared to #ZFPs are highlighted in the @WhiteheadInst press release:
https://t.co/Ht8tp5qm6E https://t.co/5oSHE4Whc5 $SGMO #CRISPR #epigenetic @chromamedicine @SangamoTx #genetherapy
The Weissman lab researchers decided to replace #Cas9 with a much smaller zinc finger protein (#ZFP). #ZFPs are also common in human cells, meaning they are less likely to trigger an immune response against themselves than the bacterial Cas9. #SGMO @chromamedicine @SangamoTx
@RNAiAnalyst I care less about the author list than the fact that they used $SGMO #ZFPs https://t.co/DbW0ShlSBf
A CHARMed collaboration created a potent therapy candidate for fatal prion diseases:
Brainwide silencing of #prion protein by #AAV-mediated delivery of an engineered compact epigenetic editor. $SGMO @SangamoTx
https://t.co/Ht8tp5qTWc
https://t.co/X0lXRTqIu2
The Weissman lab researchers decided to replace #Cas9 with a much smaller zinc finger protein (#ZFP). #ZFPs are also common in human cells, meaning they are less likely to trigger an immune response against themselves than the bacterial Cas9. #SGMO @chromamedicine @SangamoTx
Researchers Che Julius Ngwa & colleagues provide the first comprehensive classification of zinc finger proteins #ZFPs of the #malaria parasite #Plasmodium falciparum.
Read this #OpenAccess Microreview in @CellMicrobiol.
https://t.co/6NQYlaeCUR
Die #AfD fällt auf das "dümmstmögliche Angebot" herein - 🤡🤡🤡
Wundert mich nicht.
#FlyerserviceHahn
#noAfD
@politicalbeauty @JanJosefLiefers Ehrlich gesagt bin ich sehr verwundert und enttäuscht über den Tweet des #ZfPS. Echt jetzt - @JanJosefLiefers angreifen und zur politischen Propaganda der Regierung schweigen 😳. Haben wir hier einen massiven Bias oder hab ich etwas falsch verstanden #ZfPS??
+ Geschacklos und pietätlos! +
MdA Martin #Trefzer hat anlässlich des Gusses eines Betonfundaments für die #Aschesäule am #Reichstag seine Kritik bekräftigt:
„Die Installation des #ZfPS ist an Geschmacklosigkeit und Pietätlosigkeit nicht zu überbietet."
https://t.co/FYaMFyqzEc
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