Top Tweets for #aeipf
@LPearmain @CallahanPulm @tkulkarn1 @KaminskiMed @leticiakawano @IPFdoc @KerriBerriKerri @drdayjee @ahajaricase Exactly. After the publication of #EXAFIP RCT in 2022 (PMID: 34506761), it was decided to launch #EXAFIP2: Glucocorticoids Versus Placebo for the Treatment of #AEIPF
(NCT05674994).
@tkulkarn1 @leticiakawano @IPFdoc @KerriBerriKerri @KaminskiMed @drdayjee @ahajaricase There is no global consensus on the dose of steroids to use. It varies by region/country and often between ILD specialist centres. E.g., in my centre the most used steroid dose for #AEIPF is Prednisolone 40 mg/d for 2 weeks, with a slow reduction of 5 mg every 2w up to 10 mg/d.
@tkulkarn1 @leticiakawano @IPFdoc @KerriBerriKerri @KaminskiMed @drdayjee @ahajaricase 🧵 Regarding standard treatment with steroids, given that it is #AEIPF, the ideal would be to have a study arm without steroids. But I am aware that it is difficult to do so in a conventional RCT. Good initiative, looking forward for the results 😃👍
@KaminskiMed @smlungpathguy @KerriBerriKerri @IPFdoc @leticiakawano 🧵 The impact on the number of acute exacerbations #AEIPF should be further studied in the long term, for both antifibrotics. Finally, the opinion of the patients through questionnaires of QoL (symptoms, tolerability, etc) is also essential for a holistic approach. #CureIPF 🫁🌎
@leticiakawano @virenkaul @aasimhasany @KerriBerriKerri @AneesaDas @subanichandra @GallodeMoraesMD @gretchemaben @accpchest @KK_52tan @jonas_schupp @KathleenLindell @yingzezhang @Simmons_ILD @rjhomer57 Actually the way they are defined #AEIPF are probably not that heterogenous. And OP is rarely seen. AE of other ILD are a different story. The question of an infectious or environmental triggers is fascinating. We need good longitudinal cohorts to assess that. @herazo_maya?
@leticiakawano @virenkaul @aasimhasany @KerriBerriKerri @AneesaDas @subanichandra @GallodeMoraesMD @gretchemaben @accpchest @KK_52tan @jonas_schupp @KathleenLindell @yingzezhang @Simmons_ILD @rjhomer57 @jonas_schupp (before becoming a #SingleCellGuru) with Dr. Antje Prasse profiled cytokines in #AEIPF BAL. They did NOT see overt IL1B, TNF inflammation, instead ⬆️IL1ra, CCL18, CCL22 alternatively activated macrophages - not sure steroids target them https://t.co/ypWWUfUMqv
@leticiakawano @virenkaul @aasimhasany @KerriBerriKerri @AneesaDas @subanichandra @GallodeMoraesMD @gretchemaben @accpchest I'm not aware of studies comparing tissue histology in early vs late #AEIPF. In our molecular profiling study (old, but still the ONLY one methinks) we saw cell death and DAD, but no evidence for the type of inflammation one would treat with steroids https://t.co/f0BSe8Pclf
@KaminskiMed @virenkaul @KerriBerriKerri @leticiakawano @AneesaDas @subanichandra @GallodeMoraesMD @gretchemaben @accpchest @KaminskiMed the talk focused on what we don’t have evidence on including steroids (which we somehow continue to use???) and the evidence update was on what it did not work. The only good from the recent RCTs was to know that we can design and recruit for #AEIPF RCTs!
@virenkaul @KerriBerriKerri @leticiakawano @AneesaDas @subanichandra @GallodeMoraesMD @gretchemaben @accpchest Could the outcome of this session be a public letter requesting “On behalf of #CHESTTrainees (and of our patients) we demand #RCT in #AEIPF - it’s time our mentors build the infrastructure for us to implement #EvidenceBasedMedicine to prevent & treat AE-IPF ” #RemapILD #CHEST2021
@virenkaul @KerriBerriKerri @leticiakawano @AneesaDas @subanichandra @GallodeMoraesMD @gretchemaben @accpchest I do not want to troll a dear #MedTwitter friend like @virenkaul but shouldn’t the title be “No Evidence update on the management of #AEIPF” #JustSaying #GrumpyPulmonologist #CHEST2021 #NoEvidence
Thanks to the @NCICNHS team for developing #ILD care and supporting cross-regional working with @NewcastleHosps 👉🏼Just to be clear to all, the fantastic talk on #AEIPF was given by 🏴Prof John Simpson🏴#Freeupgrade
Great afternoon of learning at the Northern ILD network update. Thanks to all the speakers for really informative and interesting sessions #ILD #interstitiallungdisease #IPF #pulmonaryfibrosis #respiratoryphysio @NCICNHS @NewcastleHosps @ChestClinicRVI
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