Top Tweets for #complement_therapeutics
Iptacopan/LNP023, an #oral #factorB inhibitor, shows efficacy as add-on therapy in a single-arm, phase 2, proof-of-concept trial
in #PNH patients who are poor responders to #eculizumab @TheLancetHaem #complement_therapeutics #trials https://t.co/OieSx8W1t6
Phase III results of #C5aR1-targeting #avacopan in #ANCA_vasculitis are now out in @NEJM Avacopan shown to be superior to prednisone taper with respect to sustained remission at week 52 #complement_therapeutics #trials https://t.co/QiR77N4mqC
Characterizing the original anti‐C5 function‐blocking antibody BB5.1 for species specificity, mode of action and interactions with C5 #complement_therapeutics https://t.co/Qh4q5MKg7x
An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase #C4inhibitor #complement_therapeutics #complementbiology #nanobodies https://t.co/NlL3f9pGkt
The arsenal of #complement_therapeutics keeps expanding! A new C3 specific #nanobody that blocks all three activation pathways in the human and murine complement system now reported by @gregers_rom et al @jbiolchem @AarhusUni
https://t.co/eI0VnCt5ki
This officially wraps up a fruitful collaboration between @FrontImmunol & @AegeanConf that could not have arrived at a better time for the changing landscape of #complement_therapeutics A big thank you to @LambrisLab & Edimara and to all authors for their great contributions!
Mastellos @dmastellos , Reis & Lambris edited a timely collection of #review articles authored by leading academic and clinical experts in #complement pathobiology and clinical translation.
Download the eBook for free: https://t.co/iXNaTOgIjJ
#immunology
Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS | Blood | American Society of Hematology #APS #thrombosis #CAPS #complement_therapeutics #biomarkers #assays https://t.co/tdwxzfDs1F
To block or not to block complement #C3 activation? Not a 'one size fits all' approach...It all depends on the context: local inflammatory milieu, source & magnitude of C' activation and underpinning pathology #retinitisPigmentosa #complement_therapeutics #complementbiology 👇
C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa https://t.co/5P7soqkSj3 part of a special collection of articles on neuroscience for #SfN19 https://t.co/4v2LPG5e8h
Breaking news: Drugmaker Alexion to buy biotech Achillion in $930 million deal #complement_therapeutics #RareDisease @PNHSupport @aHUSAllianceAct @aHUSUKvoice @aamdsif @CheckOrphan @eurordis @RareDiseases @rarediseaseuk https://t.co/ExhfyNgjkv
Vasishta Tatapudi & Robert Montgomery from @nyulangone discuss in this review @FrontImmunol the promising prospects of applying #complement_therapeutics in #kidney #transplantation @nyuniversity https://t.co/J7y3IAhhMx
Using #complement_therapeutics as an example we posit that therapeutic #innovations of potentially great clinical impact should embrace the overarching values of research #accountability, #data #transparency, #openess and scientific peer-reviewed #validation 4/
Complement Inhibitors in Clinical Trials for Glomerular Diseases @FrontImmunol #complementbiology #complement_therapeutics #KidneyDisease https://t.co/XwnSbVxLLN
@NatRevDrugDisc @UniBasel @LambrisLab @PennMedicine Glad to share this readcube PDF link that provides full-text access to our #complement_therapeutics review in @NatRevDrugDisc https://t.co/xwdJWqJ3ow @aHUSAllianceAct @aHUSUKvoice @aHUSAlliance @aamdsif @PNHSupport @CheckOrphan @NCSR_Demokritos @eurordis @MORL_UIowa
@NatRevDrugDisc @UniBasel @LambrisLab @PennMedicine With a focus on clinical-stage #complement_therapeutics emerging as new treatment options for patients with #rarediseases #orphandrugs #clinicaltrials @NCSR_Demokritos @PNHSupport @aHUSUKvoice @eurordis @RareDiseases @CheckOrphan @aamdsif @PNHToday @NationalaHUS @ParisTxGroup
The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System #complementbiology #thromboinflammation #microparticles #complement_therapeutics https://t.co/A49oriSdjY
Here's to the first small-molecule #inhibitor of #complement C5 reported in @nchembio by the @Novartis team! The drug development pipeline of C5-targeted #therapeutics is getting really 'overcrowded' ;-) https://t.co/9bKg9x0vGm #complement_therapeutics #structure #C5convertase
Worth checking out in @FrontImmunol: Anti-complement treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for proximal complement inhibition? #PNH #eculizumab #C3inhibitors #compstatins #FD #FB #complement_therapeutics #clinicalTrials https://t.co/UiSlGH0AoE
Failure of the anti-C5a monoclonal antibody IFX-1 to show clinical benefit over placebo in a multi-center #Phase2 study in patients with the inflammatory #skin_disorder #HidradenitisSuppurativa #complement_therapeutics #trials https://t.co/8VMorghzlm
Our @FrontImmunol research topic on #complement_therapeutics & related #diseases has now drawn its submission curtains Kudos to all #reviewers for their hard work, insightful comments and immense help in improving the content and scope of this collection!
https://t.co/QN7ZmNdfcr
Worth checking out this paper in @JCI_insight: Complement receptor #C3aR1 controls neutrophil #mobilization following spinal cord injury through physiological antagonism of CXCR2 #neutrophils #spinalcordinjury #complement_therapeutics #complementbiology
https://t.co/2SGQ9yPvjz
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