Top Tweets for #contractile
#MechanicalStress to #MetabolicDysfunction & #Contractile impairment with #Cytoskeletal #Remodeling & #AMPK #Signaling as potential #TherapeuticTargets in #HeartFailure https://t.co/KwwOSM3X7Y @MarguliesLab #TranslationalScience
It is performing motions based on #contractile activities and thus creates visible #blebbing effects.But it is no living cells and lacks a nucleus: #Blebbisomes are large and a new discovery.
#Cells can #communicate with each other. This is an important property in organisms with complex tissue differentiation. Only in this way can complex #physiologicalprocesses be efficiently controlled. This communication does not occur solely via electrical impulses, as we know them from nerve cells. Genetic information, lipids, or proteins that were previously secreted from a cell in #vesicles are also transferred. Such vesicles are called #extracellularvesicles (#EVs).
According to the authors D. K. Jeppesen et al. (2025), such EVs also serve "cell-to-environment intercellular communication."
For the first time, the researchers observed particularly large EVs, up to 20 µm in size, that are surrounded by a #membrane and can actively perform movements, which the authors describe as blebbing. Based on this ability, they named this type of extracellular vesicles "blebbisomes." They even contain #organelles such as functioning #mitochondria as well as "#multivesicularendosomes." Blebbisomes can be formed by normal cells as well as cancer cells. The phenomenon has been observed in both mouse and human cells.
Text Stefan F. Wirth, Berlin October 2025
Reference:
Jeppesen, D.K., Sanchez, Z.C., Kelley, N.M. et al. Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties. Nat Cell Biol 27, 438–448 (2025). https://t.co/WNtdxhMKBa
I am excited to finally be able to share with you our work reporting the first Extracellular Vesicle with a personality! This video does not show a cell, it is a Blebbisome! #CellBiology
https://t.co/ABCCCZ5fPp
Dr @LanderNoelia reviews the structure of #cAMP compartments in #Trypanosoma #cruzi. #Contractile #Vacuole #Environmental #Sensing #Flagellar #Distal #Metacyclogenesis #Osmoregulation #Signaling #Microdomains @uofcincy
https://t.co/vZcWeUapr4
If long #ncRNA, #CBP, and #H3K27ac orchestrate #VSCM #proliferation and #migration, and #P300 inhibits migration and activates #contractile #genes, where do we target therapy? Would it be better to target #myocardin alone? 👇🧵
@HaoYin20 @CMPLPUCCHILE @lipo_fan @society_eas 👇🔬
In this 📑, @Helle_123 & @JordiLambert discuss how lessons from epigenetic studies of cellular regulation in other fields could help in translating the potential of targeting VSMC phenotype conversion into novel therapies in CVD
🔗https://t.co/DF4ALg68dH
@hfj22 @society_eas
#NewPaperAlert: Paper just out in @FrontCVMedicine on #contractile #function differences between left and right #myocytes in #AF.
Thanks to the reviewers and congrats to the Authors! #CardioTwitter
https://t.co/3E4qXxUhNo
Our next #EditorialBoard member is @tigerheartlab! Dr Tim Domeier is Assoc. Professor @mumedicine @Mizzou and his research explores the mechanisms of #calcium #homeostasis and cardiac muscle #contractile function in cardiac disease.
#CardioTwitter @ISHR_NAS @ISHR_ECI
8) Before discussing clinical features, dx, & tx, let’s go back to basics: How does 🫀 muscle contract? Let's look specifically at excitation-contraction coupling and how left ventricular #contractile proteins interact in order to generate pumping of 🩸throughout the body.
Results: In this study of the #MICrONS 🐭👁️-cortex 3D #ElectronMicroscopy dataset, I show how the shape of #Contractile #MuralCells transition from #PenetratingArteriole to #PrecapillarySphincter to #Capillaries. Vascular lumen = blue, mural cells = various colors (5/15)
Catch @c_mayerl 's co organized symposia while at @SICB_ Austin -
Biology at birth (https://t.co/GEFpD7bVha)
& read his recent co authored
Regional Variation in #Contractile Patterns & #Muscle Activity in Infant Pig Feeding
https://t.co/1lErGrxJHN
#oropharyngeal #evolution
#ArticlesInPress: Smooth muscle cell FTO regulates #contractile function
(Luse, et al.)
https://t.co/BXPpzjdHiW
@drlaurenbiwer @conn_pann_fun @mgood695
@MedicineUVA
#SmoothMuscle #BloodPressure #contractility
In this work, we used human platelet lysate-based #nanocomposite hydrogels (HUgel) to generate the first #contractile skeletal muscle tissues in a xeno-free system #tissueengineering 👇⬇️
Since #coffee we've had super cool talk from #PetrLeiman complete w #molecular #movies on #contractile #injection #systems & now an excellent person I've just met @Ida_deVries @nki_nl on #AlphaFill a way to put #metals & #cofactors into #AlphaFold #models
Released today @EMDB_EMPIAR & @PDBeurope, & published @NatureMicrobiol, the stunning 3.2 Å #SingleParticle #CryoEM structure of a #bacteriophage tail-like #contractile injection system uniquely anchored in #thylakoid membrane stacks.
1/3
アメーバにも収縮胞があるんですね。現れる場所が同じではないように見えるのですがどのような仕掛けなのでしょう。アメーバの同じ位置というのも謎ですが。
#アメーバ
#Amoeba
#収縮胞
#Contractile vacuole
こちらはツリガネムシの収縮胞。柄の動きが主体の全体像ばかりで、ようやく見やすいものをディスクから掘り出しました。
#ツリガネムシ
#Vorticella
#収縮胞
#Contractile vacuole
Joost Luiken's lab has shown that supplementing with Lysine, Leucine and Arginine repairs lipid-induced #insulin #resistance and #cardiomyocytic #contractile #dysfunction.
@MaastrichtU @elsbiomedchem
➡️https://t.co/RVDQltj7YO
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