Top Tweets for #elastase
1 "nouveau virus" n'est pas TJS si différent de son prédécesseur ou ses cousins.
L'ignorer a conduit à
mal prendre en charge le COVID
= observer des décès ÉVITABLES.
SARS->nétose
➡️Les #NETs se préviennent!
@D_Deplanque
@philippefroguel
@institutpasteur @CNRS
@inserm
#elastase
@2r2d75 @AtheePrat @delamare41 @Dom1719088182 @GilbertDeray During the outbreak of SARS
a known history of DM
& ambient hyperglycaemia
were independent predictors for death & morbidity.
In the recent outbreak of MERS over 2/3 of all case fatalities occurred in patients w/ co-morbid DM.
Diabetes & chronic infections
https://t.co/QCenFi5ac0
Therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells: a step forward for improving immunetherapy
Here preclinical and first in human trial shows promising rational @OncoAlert @CellCellPress #elastase https://t.co/QWXiIl411y
🔴 What's new:
💥 #Neutrophil #elastase, NGAL and lactoferrin #serum levels significantly decreased over 2️⃣ years of #infliximab #treatment despite stable neutrophil levels❗️
🔵 @drRobinDud 🔵
🔴 @SN_gastro 🔴
#UEGJFridays #IBD #MedEd
Role of #neutrophil extracellular traps (#NETs) in #rheumatoid #arthritis (RA) pathogenesis
🔹RA neutrophils are prone to releasing NETs, where #citrullinated antigens (Cit-Ags), #carbamylated antigens (Car-Ags), and neutrophil #elastase (NE) are externalized.
🔹NET-cit- and Car-Ags are endocytosed by fibroblast-like #synoviocytes (FLS) and presented to antigen-specific T cells, leading to the generation of anti-citrullinated protein antibodies (#ACPAs) and anti-carbamylated protein (CarP) antibodies by B cells.
🔹Released NE cleaves peptidyl arginine deiminase (PAD)-2 from FLS. NE also degrades cartilage, and the resulting fragments are citrullinated by PAD-2 released from FLS.
🔹These antibodies can generate #immune complexes that, in turn, activate macrophages to release pro-inflammatory #cytokines.
🔹Carbamylated histones released within NETs trigger accelerated osteoclastogenesis after engaging TLR4. ACPAs, cytokines, rheumatoid factor and #immunocomplexes activate neutrophils to release NETs, creating a vicious cycle that can perpetuate #inflammation and joint damage.
*Carmona-Rivera C, Nakabo S, Kaplan MJ. Unraveling the role of neutrophil extracellular traps in rheumatoid arthritis: From triggers to therapeutic targets. Semin Arthritis Rheum. 2024
🔗https://t.co/7VKEMMPWCe
Elastase-targeting biomimic nanoplatform for neurovascular remodeling by inhibiting NETosis mediated AlM2 inflammasome activation in ischemic stroke.
| Huae Xu, Nanjing Medical Univ. |
#elastase #inflammasome #IschemicStroke
https://t.co/2rcAcyuAd8
Congratulations @MariaRRios3 Pleasure to be involved in this exciting project with @Giulia_Rinaldi7 @A_G_Rossi et al., @EdinburghUni @EdinUni_IRR @EdinUni_CIR 🧪🩸🧬🔬
#neutrophils #NETs #elastase #probes
Very excited to share that my latest paper has just been published! We developed a NIR probe detection of human neutrophil elastase in neutrophils!
Thanks to everyone that made it possible! 🫶🏽
You can read it here 👇🏽
https://t.co/XYuoGM7zFa
@ChemCommun @EdinburghChem
Ever hear of a single protease inhibitor blocking two different enzymes at the same time? Have a look at our most recent paper in @jbiolchem where we show simultaneous inhibition of #elastase and #cathepsin-G by the #staph immune evasion protein, EapH2.
https://t.co/w0c9GN3stc
Therapeutic effect of two strategies directed at disruption of pathogenic #neutrophil #ExtracellularVesicles in a murine #emphysema model (Genschmer et al.) - 🆕 in @ajplung from @DerekRussellMD @UABHeersink @UABPathology
https://t.co/sAk1EtWjXH
#COPD #Elastase
Localized, Transient #Elastase treatment
sponge, 5/10 min->
Sustained ascending #AorticAneurysm till 4 wk
Elastin degradation
#SmoothMuscleCell disarray+death
No #AorticDissection?
Lovely VE-cadherin+ #VasaVasorum😌
Dr Wei Guo lab @FrontCVMedicine 2023
https://t.co/AbNaCIjI9R
Read the latest @FrontGastro_BMJ paper online on
"What is the significance of a faecal elastase-1 level between 200 and 500μg/g?" via
https://t.co/gm8bSKqYKV
@RMBeattie50 @Gut_BMJ @BMJOpen_Gastro #HPB #PancreaticInsufficiency #Elastase
Read the latest @FrontGastro_BMJ paper online on
"What is the significance of a faecal elastase-1 level between 200 and 500μg/g?" via
https://t.co/gm8bSKqYKV
@RMBeattie50 @Gut_BMJ @BMJOpen_Gastro #HPB #PancreaticInsufficiency #Elastase
Read the latest @FrontGastro_BMJ paper online on
"What is the significance of a faecal elastase-1 level between 200 and 500μg/g?" via
https://t.co/gm8bSKqYKV
@RMBeattie50 @Gut_BMJ @BMJOpen_Gastro #HPB #PancreaticInsufficiency #Elastase
Read the latest @FrontGastro_BMJ paper online on
"What is the significance of a faecal elastase-1 level between 200 and 500μg/g?" via
https://t.co/gm8bSKqYKV
@RMBeattie50 @Gut_BMJ @BMJOpen_Gastro #HPB #PancreaticInsufficiency #Elastase
#Neutrophil Extracellular Traps (#NETs) Promote #Metastases of #ColorectalCancers through Activation of ERK Signaling by Releasing Neutrophil #Elastase https://t.co/SVAOIp8b1V #mdpiijms via @IJMS_MDPI
Getting to Grips with Pancreatic Insufficiency Consensus for the management of pancreatic exocrine insufficiency:UK practical guidelines https://t.co/maQp6fhruy
@RMBeattie50 @BMJOpen_Gastro @BritSocGastro @Gut_BMJ #Pancreas #elastase #pancreatitis @bapen @BSPGHAN @BDA_Dietitians
Sharing our recent work published in @an_chem
First #twophoton probe for ratiometric imaging of #elastase. We mapped elastase level changes in organs under #IBD. Thanks @CPostech @postech2020 @jis_university for providing outstanding research facilities.
https://t.co/k7vKtTHqsI
On the cover of the July issue of IOVS: "The Role of #Elastase in Corneal Epithelial Barrier Dysfunction Caused by #Pseudomonas aeruginosa #Exoproteins.”
https://t.co/v0cklaZ8ez #cornea #keratitis #Pseudomonasaeruginosa #OpenAccess #Ophthalmology
This is a phenomenal #tour_de_force!!
#Neutrophil #elastase kills cancer cells
Beautiful biology with a feast of mechanistic details.
And with a surprise at the end: #Abscopal_effect!
Bravo!!
#neutrophil to the rescue! #human -not murine- neutrophils release extracellular active #elastase that selectively kills #tumor cells via #CD95 & #histone1. Primary tumor growth attenuation instigates #CD8T to attack #metastasis!! @CellCellPress https://t.co/VZK8kLguBo
#neutrophil to the rescue! #human -not murine- neutrophils release extracellular active #elastase that selectively kills #tumor cells via #CD95 & #histone1. Primary tumor growth attenuation instigates #CD8T to attack #metastasis!! @CellCellPress https://t.co/VZK8kLguBo
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