Top Tweets for #focalAdhesion
#SmoothMuscleCell #Aging Mechanobiology
24- vs 4-mo
Rat soleus muscle feed artery
⏬Myogenic tone (so flat 45~135 cmH2O! Learn new knowledge😋)▶️rescued by 1h 130 cmH2O pretreatment
Cultured Aged SMC
👉Bulk RNAseq ⏬SMC contractile markers #FocalAdhesion
👉Faster kinetics (⏫SM α-actin filamentation ⏫vinculin clustering) to biaxial #CyclicStretch
👉Inert to Pressure➡️⏬SM α-actin filament on soft 4 kPa matrix
👉Sensitized to Pressure➡️⏫SM α-actin filament ⏫integrin β1 clustering on stiff 100 kPa matrix
Andreea Trache lab @FrontPhysiol 2025
https://t.co/uBeLrNIezG
New #Review from Kazuo Katoh, Dr. Tsukuba University of Technology🔔 Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response ➡️ https://t.co/FmEUTDjDKF
🏷️Journal @Landmark_IMR
#focaladhesion #extracellularmatrix #ECM #integrin
#FAK #Src #Cancer
🌱 A @Columbia team, including first author Dr. Rafaela Muniz de Queiroz, report a molecular mechanism where Mdm2 requires Sprouty4 to regulate #FocalAdhesion formation and metastasis independent of p53.
📕 Give it a read!
https://t.co/ojOcgeWgha
Amazing Angiogenic disorder induced by Constitutive Active Src in #EndothelialCell
See the ballooning EC outgrowth from fibrin beads, forming a dome instead of sprouts
Super-intense #FocalAdhesion
Dissembled VE-cad junction
Slow migration
@J_Cell_Sci 2024 @TEssebier @VesselDynamics
https://t.co/RMPv155ou6
#YAP #Mechanoptosis #RigiditySensing #MechanosensitiveApoptosis
pTyr357 YAP, phospho by c-Abl/Src in #FocalAdhesion then translocated to Nuclei, ➡️apoptosis of MDA-Tpm2.1 (epithelial cell) MEF (fibroblast) on soft matrix (0.25 kPa)
Cellular sensing of #MatrixStiffness dictates pro-proliferative/pro-apoptotic switch of YAP
@Haguy_Wolfenson @CellReports 2024
https://t.co/oEWON6IdML
Another #openacccess paper is out at CYTOSKELETON @CytoskelJournal! Topographical depth reveals contact guidance mechanism distinct from #focaladhesion confinement. https://t.co/6eMDQxc4Ol #cytoskeleton #research #science #cel #cellbiology #microscopymonday #Microscopy
CONGRATS to DR. @NicolasYJolivet on successfully defending his PhD thesis this morning! 2nd #PhD (and 🪓recipient!) from the @IslaMyxoLab. The #FocalAdhesion model of #Myxococcus gliding #motility is here to stay! Couldn't be prouder! 😀🦠🔬🧪🥳🍾
Check out a new paper exploring the effect of oxidative stress-induced senescence on focal adhesion structure and movement! Grateful to @kegottschalklab for the opportunity to contribute to this study.
#SenescenceResearch #OxidativeStress #FocalAdhesion
https://t.co/r8jAcF8tpV
New in @physiolrev: Membrane adhesion junctions regulate airway #SmoothMuscle phenotype and function (Zhang et al.)
https://t.co/787Z9mJ0t0
@IUMedSchool #PhenotypeRegulation #Contraction #FocalAdhesion #SignalTransduction
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. By Vipavee Niemsiri et al. @PsychiatryUcsd #lithium #focaladhesion #bipolardisorder #psychiatry #OpenAccess https://t.co/Dq2zBJNUGx
Sometimes images from the archive folder are aesthetically pleasing :)
Cells on #micropattern #actin #focaladhesion
#sciart #cellbiology #geometry
Beautiful work from @LabLappalainen where @reenak52086225 et al. give their insights on #focaladhesion composition 👏
Specialized actin nanoscale layers control focal adhesion turnover https://t.co/qb6lM7Tok9
📝 Emerging Methods and Technologies 📝
Probing invadosomes: technologies for the analysis of invadosomes
🖋️ By Ya-Wen Liu and co-authors from National Taiwan University
🔗https://t.co/34e31bDAru
#focaladhesion #invadosomedynamics #proteolyticactivity
alpha-catenin regulates #integrin adhesions and ECM mechanosensing. A new study from @aavi1907 @Haguy_Wolfenson and colleagues https://t.co/XQAqKeBO9g
#Mechanobiology #CellBiology #FocalAdhesion #Adhesion #Biophysics
Zoom on a protrusion in Xenopus neural crest cell.
Actin in red, immunostaining in green.
Can anyone guess what is the protein shown in green?
I bet you can't!!!
#Xenopus #neuralcrest #cellmigration #actin #focaladhesion
Cholesterol Metabolism & #EndothelialCell #FocalAdhesion
shRNA KD TFEB, master TF of lysosome biogenesis ->
⏬SCAP/SREBP2/HMGCR/Cholesterol
⏬β1 integrin endocytosis by Caveolae
⏫FA+#FibrillarAdhesion
Dr F Bussolino & G Doronzo labs, Angiogenesis 2022
https://t.co/lqPH1xZG3N
Mechanosensing behaviors of #EndothelialCell in response to 1D, 2D circumferential, 3D radial #CyclicStretch
15% linear strain, 0.2 Hz, PDMS membrane deformation
Alignment, Junction, #FocalAdhesion, #YAP
Dr. Yong Yang lab, ACS Appl Mater Interfaces 2022
https://t.co/z7pOVLAZiy
Depending on cytoskeleton dynamics & the need of #FocalAdhesion, cell migration comes in 2 flavors (at least): amoeboid & mesenchymal.
Immune cells generally use ameboid motility mode.
Surprisingly, #septin inhibition switched T cell migration to a more mesenchymal one!
#science
Chemorepulsive FLRT2-Latrophilin 2 axis in #EndothelialCell
⏬Cell-ECM adhesion: #FocalAdhesion assmebly, #StressFiber formation & #YAP/TAZ activity
⏫Cell-cell adhesion: ZO-1 #TightJunction
Dr. Massimo Santoro & Guido Serini labs @JCellBiol 2021 @gserini
https://t.co/IyIrHgJgIF
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