Top Tweets for #setd2
Epigenetics Update - An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events https://t.co/sursXSXtoG
#Epigenetics #MYC #ecDNA #KDM4C #SETD2 #Chromatin
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Empower your research at https://t.co/WmSYDGXnzb
Article✍️Targeting the #SETD2–#FTO–#KIT pathway as a pharmacological strategy for TKI-refractory #GIST. From Dr. Sun @CentralSouthUniversity; @Sciencedirect; @ElsevierConnect.
https://t.co/dKJnECSS2W.
Epigenetics Update - The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiation https://t.co/AnVqaUafFA
#Epigenetics #H3K36me3 #SETD2
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Gain deeper insights into gene regulation; https://t.co/WmSYDGWPJD
This Friday @UAM_IBMiB seminar: Magda Kopczyńska @kopczynska_m (@STOPlabPI) on #SETD2 methyltransferase activity in gene definition and transcription regulation. Don't miss it! #epigenetics #transcriptionTermination #chromatin
Epigenetics Update - A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability https://t.co/1hpQCsuciq
Brian D. Strahl (U at Chapel Hill) in Nat Cell Biol
#Epigenetics #SETD2 #H3K36me3
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Perfect for cancer, immunology, and aging; https://t.co/WmSYDGWPJD
SETD2 loss in renal epithelial cells drives epithelial-to-mesenchymal transition in a TGF-β-independent manner
🔗https://t.co/h15UOBMP9L
#SETD2 #TGFβ #ccRCC
#Epigenetics #camets
In summary, mutations in the lysine methyl transferase domain of #SETD2 increases expression of ribosome-associated proteins and leads to worse patient outcomes relative to other #SETD2 mutations. Lots more to do in this area! Thx to @UrologyCareFdn for funding the study!
1) Data from human cell lines and tumors suggest that #SETD2 mutations in #kidneycancer (specifically the methyl transferase function) is associated with increased expression of ribosomal genes and protein. Thus, #SETD2 may regulate ribosomes and/or translation. 2 of🧵
Our paper evaluating lysine methylation in #SETD2 mutated #kidneycancer was published in @KCA_Journal! @rob_hapke from @VanderbiltU wrote it as undergrad-now @PennMedicine MD/PhD student. I want to highlight 2 points. @VUMC_Cancer @VUMCHemOnc 1 of🧵 https://t.co/zIqpMaedGt
Just found a paper by senior author @RSeervai that cited @ABclonal_USA 's #SETD2 antibody
https://t.co/6bZyaYky4K
Angela's child Rowan has #SETD2 related syndrome. She shares this advice to newly diagnosed families: "Find your SETD2 family, make friends, share your story, and never lose hope." Read more about their family journey: https://t.co/mpuPo0fYIV #ShareYourRare #SimonsSearchlight
Our new work describing the mechanism of activation of alternative promoter in #LiverCancer #HCC. #Genereguation #AlternativePromoter #SETD2 #H3K36me3 #DNMT3B #TET1 #CGdinucleotide @UCPHAndersenLab @LLUHealth https://t.co/hXrlmGNaK2 1/15
Welcome to read🧐SETD2, an epigenetic tumor suppressor: a focused review on GI tumor, by Xiu-li Liu et al. @UFMedicine
https://t.co/yTfrqfOd9G
#SETD2 #biomarker #Cancer #tumor #pathology
#SETD2 loss perturbs the kidney cancer epigenetic landscape to promote #metastasis and engenders actionable dependencies on histone chaperone complexes: https://t.co/LwvZp2RR38
Roles of SETD2 in Leukemia -- Transcription, DNA-Damage, and Beyond [Feb 27, 2019] @anna_skucha @JessicaEbner92 @florian_grebien @IJMS_MDPI https://t.co/tdyGrpsson #SETD2 #leusm #mmsm
![mtmdphd's tweet photo. Roles of SETD2 in Leukemia -- Transcription, DNA-Damage, and Beyond [Feb 27, 2019] @anna_skucha @JessicaEbner92 @florian_grebien @IJMS_MDPI https://t.co/tdyGrpsson #SETD2 #leusm #mmsm https://t.co/59yt1bD60Z](https://pbs.twimg.com/media/FGaays_XoAcDAKF.jpg)
![mtmdphd's tweet photo. Roles of SETD2 in Leukemia -- Transcription, DNA-Damage, and Beyond [Feb 27, 2019] @anna_skucha @JessicaEbner92 @florian_grebien @IJMS_MDPI https://t.co/tdyGrpsson #SETD2 #leusm #mmsm https://t.co/59yt1bD60Z](https://pbs.twimg.com/media/FGaaxSAXsAY5rfX.jpg)
Epizyme Pipeline - SETD2 Inhibitor Advancing into the Clinic in 2021 vs t(4;14) myeloma [Mar 2, 2021] @EpizymeRx https://t.co/SeCENtwCR1 #SETD2 #mmsm #PrecisionMedicine #caxtx
New tool to probe mysterious histone methyltransferase
https://t.co/bp9103jIqg
A small starting point and smart medchem produce low nanomolar, highly selective inhibitor of #SETD2, an epigenetic writer that might spur tumors, or stall them
@ACSMedChemLett @EpizymeRx
Welcome to read the paper in Frontiers in Bioscience-Landmark: SETD2, an epigenetic tumor suppressor: a focused review on GI tumor by Xiu-li Liu @UFMedicine
https://t.co/YvEj84n4Gg
#SETD2 #Histone #Tubulin_Methylation #DNADamageRepair #biomarker #RNA_Alternative_Splicing
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