Top Tweets for #singleplot
This is a remarkable paper that addresses a fundamental question: how do genes evolve? It feels like an instant classic. #singleplot to follow soon
1/ 🧵 New work from the Clowney lab, by Margarita Brovkina and Margaret Chapman. Here, we seek an evolutionary explanation for the linear organization of genes along mammalian chromosomes. https://t.co/ojrHrwjYd8
3/ #Singleplot
F. Twort discovers Bacteriophages, later named so by d'Herelle
https://t.co/yXCL5pbvrb
First image(s) by H. Ruska (1939-40)
https://t.co/hegkxmuyp0
(scale of 1 µm)
2/ #Singleplot J. Sumner isolates urease proving that (some/most?) "enzymes are proteins", upturning a dogma
https://t.co/RI2Wrhk4hC
J. Northrop isolates pepsin (PMID: 17758437)
https://t.co/pfQEaWrGzm
Can't find a direct PMID but this is the closest PMID: 12202621
@jobruusgaard @leslievosshall Nice! i would have picked this classic graph from Bliss and Lømo (1973). I think it beautifully illustrates the entire concept of LTP (6 hours in vivo). And apparently a fun story behind the gaps in the data (either playing ping pong or napping, I've heard both!).
#singleplot is a great initiative from @leslievosshall and here's my favourite. The discovery of LTP in 1966 by Terje Lømo. "an example of a plastic change in a neuronal chain (...) which may last for hours" Notice decreased latency, implying increased synaptic efficiency
Often a major scientific discovery can be boiled down to a #singleplot in a paper. Mullis & Faloona describe "polymerase-catalyzed chain reaction". We did this paper in 1st year journal club @RockefellerUniv and concluded that nobody would ever use this method #PCR
PMID: 3431465
Often a major scientific discovery can be boiled down to a #singleplot in a paper. Lee (@nyckevil), Barnea, & Axel develop TANGO. Membrane receptor tethered to transcription factor clipped by protease activated by ligand. Cells glow when receptor ligand is sensed!
PMID: 18165312
Often a major scientific discovery can be boiled down to a #singleplot in a paper. Troemel and Bargmann @betenoire1 show that when you put a receptor for a yummy smell into a yucky neuron, the yummy smell now smells yucky (neuron not receptor encodes valence) PMID: 9346234
Not a #singleplot, but still cool:
February 16, 1956, handwritten notes from weekly @MayoClinic EMG case conference. Patient with weakness, decrement, and facilitation
➡️ First written description of Lambert-Eaton myasthenic syndrome #LEMS Notes from Dr. Lambert in black
Hi Tweeps,
I'm having fun boiling down scientific discoveries into a single plot. Someone asked if I can thread them, but instead I am hash-tagging them so you all can find them
"Often a major scientific discovery can be boiled down to a #singleplot in a paper."
Love what Leslie started with #singleplot.
In 1987, Hal Weintraub and colleagues showed that the expression of a single gene (MyoD) converts naive cells into muscle cells. Some call it master regulatory gene (not a fan of genes being masters or servants).
https://t.co/jo9VAq5bRc
Hi Tweeps,
I'm having fun boiling down scientific discoveries into a single plot. Someone asked if I can thread them, but instead I am hash-tagging them so you all can find them
"Often a major scientific discovery can be boiled down to a #singleplot in a paper."
Often a major scientific discovery can be boiled down to a #singleplot in a paper. Ebru Demir and @BarryJDickson show that expressing the male version of the fruitless gene in female flies causes them to sexually court other female flies. PMID: 15935764
Often a major scientific discovery can be boiled down to a #singleplot in a paper. @HaftingFyhnLAB @MayBrittMoser, @EdvardMoser discover the Grid Cell. Neurons that keep track of where you are in space, like a tiny GPS in your brain. PMID: 15965463
@leslievosshall "Often a major grant award can be boiled down to a #singlesentence ."
The research proposal submitted by Otto Warburg to the Emergency Association of German Science in 1921 consisted of a single sentence: “I require 10K marks”. The application was funded in full.
#singleplot
Imagine listening to the Love Song and nobody comes to your mind.
That's the final stage of being completely Single.😂🤣
#LoveSongsForSingle
#singleplot
#WorldMusicDay
Can't miss this one! Another great example of #singleplot - the era of #CRISPR started from here. DOI: 10.1126/science.1225829
@leslievosshall @NobelPrize @UMich has Niremberg’s original codon chart on display - codons on left, amino acids on top, each number is the amt of radioactive tRNA associated with the codon.
#singleplot
[you beat me to this one!]
Often a major scientific discovery can be boiled down to a #singleplot in a paper. The first demonstration that green fluorescent protein from the luminescent jellyfish Aequorea victoria can make other critters fluoresce green @NobelPrize PMID: 8303295
Hotta and Benzer (1972) “Mapping of Behaviour in Drosophila Mosaics.” Astoundingly creative paper using mosaic boundaries to map the site of action of genes involved in behavior. This one, Hyperkinetic (Hk), maps to the ventral nervous system. #singleplot
https://t.co/HxEtcSgYYq
Hi Tweeps,
I'm having fun boiling down scientific discoveries into a single plot. Someone asked if I can thread them, but instead I am hash-tagging them so you all can find them
"Often a major scientific discovery can be boiled down to a #singleplot in a paper."
Often a major scientific discovery can be boiled down to a #singleplot in a paper. Mullis & Faloona describe "polymerase-catalyzed chain reaction". We did this paper in 1st year journal club @RockefellerUniv and concluded that nobody would ever use this method #PCR
PMID: 3431465
Love this #singleplot explosion. Perhaps we should be clear that these tweets are ‘boiling down’ as @leslievosshall set out, and not implying one gel/ plot/ image is sufficient support, nor all the effort that went in
Hi Tweeps,
I'm having fun boiling down scientific discoveries into a single plot. Someone asked if I can thread them, but instead I am hash-tagging them so you all can find them
"Often a major scientific discovery can be boiled down to a #singleplot in a paper."
@leslievosshall @JoseTelesReis @NobelPrize Simply legendary.. thank you very much @leslievosshall for the #singleplot series!! We are enjoying 💯!
@leslievosshall The phase 1 in CML patients is a #Singleplot in and of itself.
https://t.co/I2LPFfeIWX
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