hausofczon

C Zon - alma científica intento de farmacéutico, biólogo celular, artista y afines 🧬💊🧫🔬 PhD Student

[ShorterLab @ShorterLab]

Autophagy Is Required for Dopaminergic Axon Development and Confers Their Responsiveness to Guidance Cues https://t.co/VmwoXw2i7z

[The Science of Parkinson's @ScienceofPD]

New research reports that "PRKN controls both direct & indirect (GBA1-dependent) transcriptional regulation of SNCA" in cellular, mice models & #Parkinsons-affected brains
https://t.co/pwg6lz8mmo

[hausofczon @hausofczon]

So happy to share with you that our work on the contribution of c-Abl-RIPK3 axis in mitocondrial dysfunction and mitophagy dysregulation got published!

https://t.co/chjb9M8qyY

[The Science of Parkinson's @ScienceofPD]

Researchers report that TMBIM6 (an anti-apoptotic ER protein) enhances dopaminergic neuron survival by modulating the IRE1a pathway in models of #Parkinsons; TMBIM6 protein levels are elevated in postmortem PD substantia nigra
https://t.co/NaXdN4lOij

[The Science of Parkinson's @ScienceofPD]

New data finds that direct current stimulation time dependently reduces alpha-synuclein accumulation (phosphorylated & aggregate forms) within neurons & increased neuronal viability; Implications for DBS in #Parkinsons?
https://t.co/yRfZOYhedC

[Sheila Macrine, Ph.D. @MacrinePhD]

Why does motor coordination keep improving into adulthood? It’s a "cellular handoff"! A new study reveals that star-shaped astrocytes take over GABA regulation in the cerebellum during late adolescence, unlocking the precise, flexible movements of adult agility. https://t.co/ak4NFHsMXq
#Neuroscience #BrainResearch #Astrocytes #MotorSkills #Cerebellum #Biology #HumanDevelopment #ScienceTwitter

[nature @Nature]

Nature research paper: Single-cell and isoform-specific translational profiling of the mouse brain

https://t.co/eIY5nDxht3

[Yin lab @HenryYin19]

I have always been interested in KCC2 and the chloride reversal potential, and this paper shows how it can contribute to in vivo behavioral function. https://t.co/GPZhlHbMzx

[Science Advances @ScienceAdvances]

The protein αSyn plays a crucial role in neurotransmission by modulating L-type calcium channel activity in neurons. αSyn deficiency reduces channel activity, compromising dopamine release in the midbrain and synaptic plasticity in the hippocampus. https://t.co/8Gz86FmCVk

[Science Advances @ScienceAdvances]

New research involving mice spotlights the vagus nerve’s role in the brain’s dopamine reward pathway. https://t.co/ts1wBaJOpr

[The Science of Parkinson's @ScienceofPD]

New paper mapping cellular vulnerability to #Parkinsons-associated a-synuclein in mice finds"αSyn path. propagates along anatomical pathways, but cell-autonomous factors determine if a neuron exposed to misfolded αSyn will develop Lewy-like path. or not"
https://t.co/BM1UDbTlQ8

[The Science of Parkinson's @ScienceofPD]

New research from @wysscoray et al explores the influence of ageing on degrading synaptic proteins; Neuronal protein half-life approx. doubles between 4 months & 24 months of age in mice; It also accumulates in aged microglia, 54% reduction in degradation
https://t.co/tUHmxccr0F

[Colton Casto @_coltoncasto]

The cerebellum supports high-level language?? Now out in @NeuroCellPress, we systematically examined language-responsive areas of the cerebellum using precision fMRI and identified a *cerebellar satellite* of the neocortical language network!
https://t.co/Q1Ia076kdv
1/n🧵👇

[Tal Laviv @LavivTal]

I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain! https://t.co/AHTspCd5mU

[eLife - the journal @eLife]

Microglia adopt fundamentally different strategies for surveilling the health of neurons during chronic neurodegeneration.
https://t.co/yZfnIfq2pT

[ShorterLab @ShorterLab]

Predicting protein-protein interactions in the human proteome | Science https://t.co/yCNebqv7P4

[John Lukens @LukensJohnR]

Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling https://t.co/Tyi3PxJwL4

[Madam Mitochondria @Madam_Mito]

Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy | Nature Communications https://t.co/GhGwGA2QG4

[Subhojit Roy, MD, PhD @Roy_Lab_Thinks]

If you're tired of AI and stuff...we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons: https://t.co/zRMfcIAd78

[Cell Reports @CellReports]

Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro https://t.co/bwl4SjONJD