Ivan Kuznetsov

[Ivan Kuznetsov @ia_kuznetsov]

https://t.co/5rGCK8t9re

[Ivan Kuznetsov @ia_kuznetsov]

Previous work suggested that the role of genes in educational attainment was higher in contemporary Estonia than during the Soviet era. With a tenfold larger dataset, our new preprint finds limited evidence to support this.

[Ivan Kuznetsov @ia_kuznetsov]

@jasonmfletcher @genomicstartu @FranceCardil @ukuv @maitbb However, the patterns of migration between the cities are consistent with what you show. We also find that longer-distance moves tend to be more selective.

[Ivan Kuznetsov @ia_kuznetsov]

Remember the famous UKB migration paper? We found that internal migration also shapes population structure in Estonia. Key patterns replicate within families.
Paper link in the last tweet.

[Ivan Kuznetsov @ia_kuznetsov]

@jasonmfletcher @genomicstartu @FranceCardil @ukuv @maitbb Thanks for sharing these, very relevant, and apologies for missing them earlier. You’re right that we don’t analyze migration flows between regions except those involving the major cities. This would be interesting to check.

[Ivan Kuznetsov @ia_kuznetsov]

7/7 Many thanks to the participants and the team at the Estonian Biobank @genomicstartu, Vasili Pankratov, who led this study, and our amazing coauthors @FranceCardil @ukuv @maitbb and Luca Pagani.
The study: https://t.co/6mqwUD5xHS

[Ivan Kuznetsov @ia_kuznetsov]

6/7 Caution is needed in interpretation: polygenic scores correlate with many traits, not just a single phenotype, and are influenced by various confounders. Further work is required to identify the specific phenotypic pathways linking genotype to migration decisions.

[Mait Metspalu @maitbb]

We are hiring! Looking for two postdocs. Topics: a) ancestry informed polygenic scores for mixed ancestry individuals and b) integrating polygenic risk models with clinically actionable rare variants for comprehensive disease risk assessment.

https://t.co/gEaxLR6SgM

[Abdel Abdellaoui @dr_appie]

Nice replication: recent migrations influenced by SES reshape the landscape of human DNA. Old geographic patterns of ancestry dissolve, giving way to new distributions of polygenic scores 🧬🧳

@uk_biobank paper: https://t.co/TUMiOkb0sH
@ESTbiobank paper: https://t.co/zXOCBt5USm

[Ivan Kuznetsov @ia_kuznetsov]

Assessing the impact of 20th century internal migrations on the genetic structure of Estonia https://t.co/oPFFSDSNIX

[Ivan Kuznetsov @ia_kuznetsov]

Excellent overview of our preprint!
Here we explore how recent migrations have altered the population structure in Estonia, generating G-E correlations, and hypothesise on why this could occur

[Shai Carmi @ShaiCarmi]

An interesting preprint from the Estonian biobank.
Across 180k genotyped Estonians, the authors looked at how genetic structure and polygenic scores for education were shaped by migration to Estonia's big cities.
🧵
https://t.co/9nOFhl7kLo

[Ivan Kuznetsov @ia_kuznetsov]

Link for free access https://t.co/8M482GtjG0

[Ivan Kuznetsov @ia_kuznetsov]

Genotype-by-environment interactions in chronic back pain https://t.co/vjboUa3yxN

[European Journal of Human Genetics @ejhg_journal]

Adult height is the exemplar complex trait; the more individuals we include in a study...the more complex models to predict height need to bt.
https://t.co/j7mrQHZy4y