Katie

yeah yeah yeah

[Cameron 🇺🇸 🗽🦅 @CameronCorduroy]

"the Republican Party is ideologically committed to impregnating as many teenage girls as possible" is an objectively true statement that is taboo to admit in mainstream politics

[Eric Michael Garcia @EricMGarcia]

I have talked about this at length. The women in Washington are fabulous. A lot of times, they are driven, determined, hard-working and emotionally mature and well-adjusted. The fellas are all emotionally stunted dweebs who never got over being told they were the smartest kids in 8th grade. That means their social skills are sorely lacking (and yes, I am including myself in this).

[Lady Voldemort @LadyVoldemort09]

My mom is an extreme martyr and so is my oldest friend’s mom. We decided that it’s a flavor of narcissism. You don’t get extra Jesus points for suffering the most, and it really inconveniences the people you “don’t want to bother.”
Eat the fucking sandwich like a normal person

[alaska @145k4]

nolan's odyssey has reminded me of black orpheus (1959), the myth of orpheus and eurydice set in rio de janeiro during carnival. one of the most visually exciting movies i've ever seen

[✨ @shellcherrypill]

“From the same team that created Netflix’s POP STAR ACADEMY—”

[Bryan Johnson @bryan_johnson]

🚨Kate officially diagnosed with endometriosis

> done without surgery
> across three modalities: imaging, blood, and AI
> all non-invasive
> in 42 days

For context, average time to diagnosis is 6.6 years.

And, we found 2 other diagnoses at the same time.

Over the past 6 weeks, we’ve sprinted to confirm or deny Kate’s suspected endometriosis. Endo is notoriously challenging to diagnose.

It’s one of the most gnarly diseases and affects 15% of women.

Men, to get you on the same page, having endo is akin to an alien growing in your guts and balls, self replicating, and glueing everything together. Causing you constant pain and discomfort.

We got to work.

> got an MRI
> got a transvaginal ultrasound
> both results came back negative

At this point, Kate’s patient journey had followed the archetype precisely. Most women don’t get diagnosed for 7-10 years. For Kate, it’s been 7 years. And, like most women, her imaging came back clear even though now we know that she has endo.

This is why diagnosis has traditionally happened via surgery. There has been no other way than to open her up and look inside.

We wanted to avoid surgery so we went back to the drawing board. We searched the world over.

On our second go, we did:

> endo-specific ultrasound
> an endo blood test
> AI MRI
> saliva test

This was successful.

We were able to confirm her endo via ultrasound, blood test, and MRI. Confirmed simultaneously by three unique modalities, as far as we know, a world-first approach.

The extensive measurement allowed us to find additional things.

Her ultrasound showed:

> endometriosis
> PMOS (formerly PCOS) (needs confirmation)
> adenomyosis

30-40% of women have at least one of these conditions. That’s intimidating especially when the path to diagnosis is fraught with so many challenges.

Phase I was getting a diagnosis.

Phase II is curing endometriosis. We’ve already started working.

If you’re a female with suspected endo, here’s what you can do to accelerate your diagnosis.

—
1. Endo-Specific Ultrasound

You want an endo-specific ultrasound. As we saw with Kate, a standard pelvic/transvaginal ultrasound failed to identify her endo.

You want the ultrasound to be performed by a physician or sonographer specifically trained. They follow a special protocol to hunt for endometriosis by mapping the ovaries and uterus, and testing whether organs can slide freely, or are tethered by endometriosis lesions.

It’s best timed just after ovulation, when a small amount of peritoneal fluid aids visualization.

It can detect superficial endometriosis, lesions, and adenomyosis that general imaging misses.

We went to Dr. Kacey Hamilton at Cedar Sinai.

2. AI MRI / MatricesAI

Radiologists miss lesions in up to 60% of cases. We worked with @MatricesAI which leverages AI and a unique dataset to detect endometriosis lesions on pelvic MRI. This model is still new, its first pilot study with 200 participants began in April this year.

Here is how you can work with them:

They’re opening their diagnosis program at the Geneviève Institute to give early access to their AI model in a clinical trial.

They will take you through a state-of-the-art clinical intake questionnaire. Help you advocate for your symptoms with your gynecologist, based on your intake or connect you to a new center where their AI is being piloted and the clinical trial conducted.

3. Blood test / HerResolve

Kate had two small tubes of blood drawn for a test built by @Heranovalifesci.

The test measures seven biological markers (three microRNAs, three proteins, and one hormone) and uses an AI model to help detect endo.

It was highly accurate in its validation study at confirming endo and caught most cases that ultrasound and MRI had missed.

Their technology has been validated in a peer reviewed study (298 women, 11 sites across US/Europe/Hong Kong, published in the Journal of Minimally Invasive Gynecology): specificity 97.5%, sensitivity 80%, with strong diagnostic performance (94.4%), demonstrating it was highly effective at distinguishing women with endometriosis from those without the disease.

A positive result is a strong signal, since only 2.5% of women without endometriosis test positive, though final confirmation is still clinical. A negative is less conclusive, because the test misses about 20% of true cases.

The test identified 61.5% of histologically confirmed cases that transvaginal ultrasound and/or MRI missed.

#

We did one more saliva based test and will report back on that when results are returned.

[Katie @iamacopp]

Clearance jobs dot com

[Dom Technostate ☭ @DomTechnostate]

Is there like a secret second Indeed where you guys are finding all these office jobs that pay a fuck ton of money

[Katie @iamacopp]

And that’s beautiful!!!

[drew @ImNotOwned]

You can go to live in France, but you cannot become a Frenchman. You can go to live in Germany or Turkey or Japan, but you cannot become a German, a Turk, or a Japanese. But anyone, from any corner of the Earth, can come to live in America and become an American.

[ela @kvtlsf]

DANIELA AVANZINI SHUT UPP

[Haley Turnbull @lescarletwoman]

I still remember hearing a mother say "i'd rather my daughter have cancer than sleep around" in regards to the vaccine. These people literally thought the vaccine was going to turn their daughters into whores, which would be worse than them dying from cancer. Insane.

[kit @lesbian_fleabag]

the #satc episode where they all hypothetically discuss who they'd have a threesome with out of the four of them & no one picks miranda which sends her to therapy is an absolute all timer. no notes. also carrie at her most 🏳️‍🌈 choosing samantha & lowkey crushing on big's ex-wife

[A Lizard Lady @LexiconLass]

As it happens, my sex ed teacher DID talk about blue balls. Made sure to tell us that it's not as big a deal as men say it is and not to let them talk us into things we didn't want to do because of it :)

[pyroxiiumn @pyroxiumn]

I’m about to say something that’ll make you mad: I just want it more

[Milay @Ivan_karamazov2]

arkadaşım 37 yaşında adama 33 yaşında kadın bulmuştu. erkek kızı beğendi iş tamam, oğlanın annesi araya girdi “çok yaşlıdır bundan sonra çocuk yapamaz” dedi ayırdı gençleri. kadın ondan sonra evlendi iki çocuk yaptı, adam elli yaşında hala bekar. anasının bastonculuğunu yapıyor

[dani ⁶ @katzdani_]

I truly am kpop's current target audience because I’m eating this shit up

[Hannah @dumbandfunn]

sounds like you only surround yourself with losers…

[Zaid Jilani @ZaidJilani]

“A family from Mexico arrives this morning legally has as much right to the American Dream as the direct descents of the Founding Fathers.”

Bob Dole accepting the Republican nomination for President in 1996.

[cory @coolmathgame_]

horror movie lovers be like i love that movie it made me feel fucking awful and horrible and really scared

[もちーぬ @mochionthetop]

エロ漫画では指一本突っ込まれただけで仰け反ってﾋﾞｸﾝﾋﾞｸﾝするほど敏感エリア扱いなのに婦人科検診になるといきなり無感覚ゾーンということにさせられるダブスタ臓器、膣