Ian Silverman

Clinical Bioinformatics - Precision Oncology @reparerx. alumn of @incyte, @ignyta, @penn & @binghamtonu. Tweets are my own.

[Ian Silverman @iansilverman]

@charlie_lees Thanks for sharing this. Very interesting history. Just collected a sample for my daughter last night

[Ian Silverman @iansilverman]

@federalreserve Should be an interesting week ahead!

[Ian Silverman @iansilverman]

@EricTopol Makes a lot of sense that there is a connection between autoimmune risk alleles and IO responsiveness. A double edged sword though…

[Ian Silverman @iansilverman]

@marcelomattar @Nature Congrats Marcelo!

[Ian Silverman @iansilverman]

@davidycli Great take! But isn’t single shot to “true platform” just… Pharma?

[Ian Silverman @iansilverman]

@IldikoMe Looks like a fabulous resource. Thanks for sharing

[Ian Silverman @iansilverman]

@bielleogy I worked on MSPA for nanopore sequencing as an undergrad and this was my favorite thing to tell people about the protein.

[Ian Silverman @iansilverman]

@ElNahhasOSM @jnkath @MOSAICgroup1 @tudresden_de @EKFZdigital @katherlab Congrats Omar!

[Ian Silverman @iansilverman]

@ChefReactions please do the meat pocket from scrumdiddlyumptious! It’s my favorite absurd cooking video of all time.

https://t.co/KEFRVy0RqQ

[Ian Silverman @iansilverman]

@besdao Someone get this kid a glasses wipe

[Ian Silverman @iansilverman]

@adbeggs Very cool. This is the way

[Ian Silverman @iansilverman]

@BiagioRicciutMD @NatureComms Important work and something I thought about frequently when working on fusions. Would be interesting to apply to 5’ fusions like FGFR2 which doesn’t rely on active transcription of the partner.

[Ian Silverman @iansilverman]

@NAChristakis @baym It is. Learned a lot listening to the first few episodes on India and even now on US history

[Ian Silverman @iansilverman]

@Dr_James_Lee @TheCrick @The_MRC @CR_UK @ListerInstitute @CrohnsColitisUK @NIHRBioResource @IBD_BioResource @JoLSchultze @Nature @RoyalFreeNHS @wellcometrust @ucl @imperialcollege That’s helpful, thank you. I’m just a simple minded cancer genomicist and struggle with population genetics and polygenic risk.

I feel like the media and most lay people probable miss this detail but it’s hard to explain.

[Ian Silverman @iansilverman]

@Dr_James_Lee @TheCrick @The_MRC @CR_UK @ListerInstitute @CrohnsColitisUK @NIHRBioResource @IBD_BioResource @JoLSchultze @Nature @RoyalFreeNHS @wellcometrust @ucl @imperialcollege Great thread James and congrats on the amazing paper! Can you comment more on the high prevalence of the risk allele in the general population. I’m struggling to understand how the risk allele can be so ubiquitous. What % of IBD patients actually have the risk allele?

[Ian Silverman @iansilverman]

@philipcball Appreciate the summary but need to clarify that Irratable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are unrelated and often confused. The focus of this paper is on IBD, which comprises crohns disease and ulcerative colitis.

[The Journal of Molecular Diagnostics @JMDiagn]

#LegacyContent: Detection of Biallelic Loss of DNA Repair Genes in Formalin-Fixed, Paraffin-Embedded Tumor Samples Using a Novel Tumor-Only Sequencing Panel. Authors from @RepareRx @MSKCancerCenter, and @Invitae

Free in the #OpenArchive: https://t.co/OCT0TLyyel

[Ian Silverman @iansilverman]

@the_artofhealth You don’t know shit about shit

[Ian Silverman @iansilverman]

@DrBPHealth What about ESR?

[Ian Silverman @iansilverman]

@MarketPalmer_ $4k/month for 1 preschooler and 1 toddler.