Stanford Immunology PhD student in the @Bendall_Lab. Interested in multiplexed brain imaging and Alzheimer’s disease. @stanfordimmuno / @astar_research
Congratulations to Dr. Rachel Ee for defending her dissertation on "APOE4 reshapes the microglial landscape of neurodegeneration in Alzheimer's disease". ❤️ 👏
#stanfordimmunology#stanfordphd#alzheimers#bendalllab
Microglia (🟢iba1) starting to express HLA-DR (🔴) when activated! It is #FluorescenceFriday! Additional markers: neurons (🟣NeuN) and Dapi (🔵). @zeiss_micro
The second annual Spatial Biology Workshop is just two weeks away! This free event will showcase the power of spatial techniques to answer biological questions. We'll be showcasing new methods for data generation and analysis, as well as the novel findings they enable (1/x)
Research Highlight by @madhuramukho: @Bendall_Lab present scMEP, a single cell method to connect a cell’s phenotypic identity to its metabolic profile. Paper in @NatureBiotech (https://t.co/NRi4HZmKbh).
https://t.co/r95cSZHTVr
For the macrophage fans:
Next Tuesday 3rd of November I will be giving a Webinar for @nature in collaboration with @10xGenomics and @illumina.
Subject: Macrophage biology in the single-cell era.
You can register here:
https://t.co/j3GpcPl0rS
I hope to see you there! Pls RT.
Full disclosure for the grad students struggling out there.
I was in lab for 15h yesterday. And my experiments didn't work. I've done this assay over 1000 times. And it didn't work. It happens sometimes.
Looking at my lab notes today to work out what went wrong.
Hang in there.
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease. (2020) https://t.co/iM79dm2zf3 APOE and TREM2 risk variants are associated with a significant reduction in a distinct subpopulation of CD163-positive amyloid-responsive microglia.
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis | SpringerLink https://t.co/rEEJ1mJfXG
What diverse ways do MG talk w neurons? Do MG exist as functional clusters & does this depend on brain region? How do we link MG heterogeneity to function? Very excited to share the first review from my lab w/ @SebastiaanDeSc2 & Ger Crowley!!! #microglia https://t.co/pkMR1mHKr2
Virtual/distanced lab rotations are not optimal, but they do show how the lab responds to stressful situations. And that is invaluable information as the pandemic won’t be the last stressful time in academia.
Some thoughts for incoming grad students 💭 👇
@AcademicChatter
Biologic & disease processes need to be viewed from an age perspective. How does your favorite gene change with age? check out Tabula Muris Senis and this App combining sc and bulkRNAseq across 10 ages https://t.co/CCljE3npfS in https://t.co/NMjKBrmpjG and https://t.co/DipHgHYE1L
Very excited to share work of Andrew Yang, supported by a fantastic team and productive collaborations with @mjameslab and @CarolynBertozzi: https://t.co/rvRsuG2uHK
Brain blood vessels soak up blood proteins defying barrier stigma. Thanks for a wonderful review by Rich Daneman!!
"Remyelination-Promoting Inflammation: Novel Role for MyD88 Signaling in Microglia/Macrophages"
@TrendsNeuro Spotlight by Gopal Murugaiyan, Mai Fujiwara & Lucien P. Garo
on Cunha et al. 2020 @JExpMed Mikael Simon group
50day free access link:
https://t.co/f4wT9Wv7l3