Pei Yee

Post-doc at Urbé/Clague lab. Previously @LMCB_UCL
Interested in membrane trafficking and ubiquitin biology 🧑‍🔬

[Pei Yee @imPeiYee]

My PhD work, funded by @wellcometrust, is out now! We showed that the #trafficking and rapid turnover of CTLA4 is #ubiquitin dependent and is linked to a complex architecture of ub chain linkages. Big thanks to @jnpruneda, Almut and Klaus-Peter for this great collab @LivUniISMIB

[Journal of Cell Biology @JCellBiol]

.@imPeiYee, Urbé et al. @LivUni characterize the role of #ubiquitin in the rapid turnover kinetics of the immune checkpoint protein CTLA4. https://t.co/0O47JHcZag

#Cancer #Trafficking #Biochemistry #ProteinHomeostasis

[Portland Press @PPPublishing]

#Immunotherapy relies on the targeting of immune checkpoint receptors and their respective ligands. Immunotherapy advancement however has outstripped our understanding of these receptors. Tey et al showcase the proteostasis of immune checkpoint receptors.https://t.co/hiZnVTC9z0

[Pei Yee @imPeiYee]

Our review "Proteostasis of immune checkpoint receptors" is out in @Biochem_Journal!

We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4.
https://t.co/aSw14dTstj

[Kirsty McMillan @KirstyJMcMillan]

We have an exciting 18 month postdoc position available in our new lab in Liverpool. If you have experience in primary cultures and are interested in Endosomal Biology and Neurodegeneration do take a look. Please repost and share.
https://t.co/jWslLiVF7E

[Journal of Cell Biology @JCellBiol]

.@impeiyee, Clague, Urbé et al. characterize the role of #ubiquitin in the rapid turnover kinetics of the immune checkpoint protein CTLA4. https://t.co/6jOHiWtbsX

📕 In Immune Cell Biology 2025: https://t.co/4lt3gifYUX

#AAI2025

[Pei Yee @imPeiYee]

@valeria_marotta @Official_BSCB Thank you!

[Pei Yee @imPeiYee]

Deeply honoured to receive the 2025 Raff Medal!
Huge thanks to @Official_BSCB for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.

[BSCB @Official_BSCB]

Congratulations to our 2025 Raff PhD medal winner Pei Yee Tey

https://t.co/47IBd4Tnp3

[Molecular Cell @MolecularCell]

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains https://t.co/XlaRUXzWnO

[Hofmann_Lab @LabHofmann]

Our paper on bacterial clippases is now out in @MolecularCell. These really interesting enzymes can make deconjugation of #ubiquitin irreversible. Thanks to @UniCologne and @C2fBiochemistry for support.
https://t.co/78lxodHhQa

[Pei Yee @imPeiYee]

Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import https://t.co/ADCHscDXXS

[Science Magazine @ScienceMagazine]

"Research is messy. … Trying to protect students from that reality does them a disservice."

On #InternationalDayOfEducation, take a look back at this #ScienceWorkingLife on teaching students about scientific failure. https://t.co/LG0prXpxYf

[Rashmi Agrata @Rashmi_Agrata]

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩:
Excited to share our review article in @MolecularCell , diving deep into everything #ubiquitin

Read here 👉 https://t.co/i30YRMmGi1

@CellPressNews
@WEHI_research @komander_lab

[Natalia Sanchez-Soriano @Natsansor]

🚀 Hot off the press! Our latest findings from @LivUniISMIB on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team!
https://t.co/jzqTg7BF2J

[Valeria Marotta @valeria_marotta]

I am excited to share that my PhD work was published in @emboreports this week. A collaborative work of amazing scientists that I had the pleasure to work with! Go and check it out! https://t.co/Lzg6mOyocw

[Pei Yee @imPeiYee]

@valeria_marotta @emboreports Congratulations!

[Pei Yee @imPeiYee]

My friend, Victoria, is joining the knitting/crocheting challenge this December to raise funds for @CR_UK. She created thoughtful science-inspired crochet gifts for our lab members (pics attached). Donate here if you'd like to show your support! https://t.co/TfzVqvCktJ

[MRC PPU @mrcppu]

Ian Ganley awarded prestigious 2025 Hooke Medal https://t.co/wR9dEN1HVK @LabGanley @Official_BSCB

[Pei Yee @imPeiYee]

Mon amie @IoannaCGeorgiou won the poster prize at the PINK1 meeting a week before passing her PhD viva 😊 There she was receiving the certificate from Mr PINK1. Very well deserved 🎉

[Biochemical Society @BiochemSoc]

We hope everyone enjoyed PINK1 pathway to Parkinson's disease last week! Commemorating 20 years of research, a special congratulations go to Ioanna, Nafizul and Wolfdieter who all won poster prizes.
@biochem_journal

[Journal of Cell Biology @JCellBiol]

#Ubiquitin chain restriction (UbiCRest) analysis reveals K63, K27, and K29 ubiquitin chain association with CTLA4-HA. From @imPeiYee, Urbé et al. showing that rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation https://t.co/qDG54sHKFH

[Journal of Cell Biology @JCellBiol]

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation, say Pei Yee Tey (@imPeiYee), Sylvie Urbé @LivUni and colleagues: https://t.co/bIbhTyiehj

#Cancer #Trafficking #Biochemistry #ProteinHomeostasis #ubiquitin

[Jonathan Pruneda @jnpruneda]

Check out this beautiful study from @imPeiYee, now published in @JCellBiol!