Eric Geertsma

Membrane biochemist @mpicbg with a strong affection for solute carriers and their transport mechanisms. Dreams big about nanobodies. Will one day own a herd.

[Eric Geertsma @inverted_repeat]

@AhmadRezaMehdi1 @seegerlab @NatureComms And thank you for your help with this guy as well!

[Eric Geertsma @inverted_repeat]

Man-made hinges date back to 1600 BC. ⭐️postdoc Benedikt Kuhn et al. now show that elevator-like #solutecarriers had them long before 🤩 to control conformational space + function!
Great collab w Julian Langer lab and @seegerlab. Out in @NatureComms
https://t.co/EoNqdqCB6l

[Eric Geertsma @inverted_repeat]

Positive news for negative ions! 👉@HendrikSikkema received a #MSCA postdoctoral fellowship!!! 🎉🥳
QuantiCl will study anion transport in organ development & function @mpicbg . Stay tuned!😊

[Eric Geertsma @inverted_repeat]

@Josy_terBeek @BerntssonLab @UmeaUniversity I had a fabulous time at @UmeaUniversity and the @BerntssonLab. Thx for having me!
What I learned:
1) Umeå ≠ Umea 🙃
2) Umeå is not only cold, it's also a very cool place! Great people, great science, great infrastructure! 👍
3) nice labmates last forever. Pick yours carefully!

[Eric Geertsma @inverted_repeat]

@jvveenvliet @mpicbg Simple: steered back to soon after metal pole 👉 pannier hit pole 👉 kryptonite lock in respective pannier flew in wheel 👉 lock followed wheel rotation 👉 lock forced metal rod of mudguard upward 👉 bend mudguard.
I suggest this sequence only to people that know how to bike 🙄

[Eric Geertsma @inverted_repeat]

A true achievement @mpicbg: I managed to secure bike-stand #1. That will be a lot of walking on campus today cause I am not gonna give up this baby.. 😎

[Eric Geertsma @inverted_repeat]

@CPaulino_ Following the triplet Frankfurt/Zurich/Groningen, Germany is the logical next step, I hear ya Christina! Congrats and welcome back! 😃

[IMPRS-CellDevoSys @imprs_mpicbg]

#Biophysics #Lifesciences #Chemistry Looking for interdisciplinary backgrounds for our diverse projects, from @jvveenvliet @tablerlab @lepuslapis @DoraTang5 @MOSAICgroup1 @ClaudiaGerri @c_kurzthaler @inverted_repeat @carldmodes @rita_d_mateus 🐠🧪🧮🔬🐁

[Eric Geertsma @inverted_repeat]

@IHanelt @jakobsilberberg Meanwhile @IHanelt was cracking the tough nut of integrating the complete spectrum of integrative structural biology methods for studying conformational dynamics of membrane transporters at our #mPEPC2 course in @EMBLHamburg. I was there! #proudformercolleague 😀

[Eric Geertsma @inverted_repeat]

It has a name!
Connectionless beta-helix or beta-helix nanotube!
First proposed by.. 🥁Max Perutz in 2002.
Described in more detail here: https://t.co/6qxmbo1rpP
Credits to @Poslab_RND

[Eric Geertsma @inverted_repeat]

Somewhat confused.. anyone ever stumbled over this 👇 structural element? What is it called? An alpha-helical beta-strand? 🙄
Or is this AI-fantasy?💥🌈🦄
Found in #alphafold's Period: https://t.co/WKSOicX3ps

[Eric Geertsma @inverted_repeat]

@iamgkadam @AthiNaganathan @okapik fantasy: if it exclusively exists in the (deep)mind 😉
confident: never
reasonably confident: if we as a community fail to get experimental support in a 2-3 year timeframe

[Eric Geertsma @inverted_repeat]

@CoskunPLID @mpicbg @LangeNacht_DD 🙃..and then you did not even hear me speak german(-ish)! 👉https://t.co/hbWPW1Kirw (with subtitles!) 😎

[Eric Geertsma @inverted_repeat]

Wow! 👇Well-earned!😀🍾

Bert Poolman appointed Knight in the Order of the Dutch Lion https://t.co/vW2imSpXQC

[Eric Geertsma @inverted_repeat]

@kudryashev_lab @MDC_Berlin Congratulations Misha!
The east is the new west! 😉😎

[Eric Geertsma @inverted_repeat]

From mega to macro to pro-macro.. and my guess is this is not the end of it yet. 😎
How a small #nanobody turned big and rigid (and on the fly contributed to the structure of the LptDE outer membrane protein complex!!!)👇

[leadXpro @leadxpro]

leadXpro is happy to report the structure of LptDE - solved by cryo-EM at high resolution - which provides structural basis for the discovery of novel antibiotics targeting lipopolysaccharide (LPS) transport on the bacteria outer membrane. https://t.co/IkUonqDWCG

[Eric Geertsma @inverted_repeat]

@BjornPPedersen Insane idea from the 50s!
But then again, maybe not so insane..👇 (okay, primary transport and "only" 90 degrees in plane, but still! 😉)
Let's see what's out there. At least the name is coined Bjørn! 😎
https://t.co/8tAadVCtn2

[Eric Geertsma @inverted_repeat]

The #alpacalypse continues..
https://t.co/2SUBN5d1ZG

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

24 yrs ago, Roger Tsien et al introduced the first fluorescent biosensors based on #GFP. Today, we introduce the first acoustic biosensors based on #gasvesicles. Now it's possible to image the action of specific molecules (enzymes) in the body w/ultrasound https://t.co/OoRgCC3Lew

[Eric Geertsma @inverted_repeat]

https://t.co/piwfbjLuGH