Wei Wang

Looking for PostDoc Positions

PhD student in @PKU1898.
Working on #LongReadSequencing #TransposableElements #Multiomics #Bioinfomatics

[Wei Wang @IrvingWang18]

Thanks for ​​Tomoya's attention!
🧵 [1/9] A single-oocyte long-read transcriptome reveals a hidden layer of isoform diversity and TE-mediated stability in human and mouse oocytes.
Here’s what we found 👇
#IsoSeq #Oocyte #transcriptomics #TE #singlecell 🧬

[TAKASHIMA Tomoya @TomoyaTakashima]

Single oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability during oocyte maturation https://t.co/SS28vmrCgA

[Sergiu P. Pasca @Sergiu_P_Pasca]

Today in @Nature, we report a new approach to studying human brain development and modeling disease in vivo.

Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations. Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.

To address some of these limitations and obtain more advanced functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex and hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.

We call these #xenocortical mice (XCX).

Nearly 7 years in the making. Congratulations to an extraordinary team and wonderful collaborators!

Link to the article below 👇

[James Zou @james_y_zou]

Thrilled that #paper2agent is published in @nature today!

Scientific knowledge is traditionally stored in passive papers. Paper2Agent transforms papers into virtual authors that answer questions, apply its methods and collaborate w/ other paper agents to make new discoveries 🧵

[nature @Nature]

Nature research paper: An operational perturbation proteomics-based virtual cell model

https://t.co/H4Fu6zucT5

[Martin Pera @martinperaJAX]

Wt1 splice isoforms bias lineage programmes during formative pluripotency https://t.co/eqZ2maEbLx

[Zinan Zhou @zinan_zhou]

Excited to share our new review in Nature Reviews Neurology, written with my postdoctoral mentor @ChrisAWalsh1 ! We discuss how somatic mosaicism arises in the brain across development and aging, and its emerging roles in neurodegeneration.

[FlyWire @FlyWireNews]

Want to build your own fly simulator on the BANC connectome (the full brain + CNS from a female fly, ~160k neurons)? Here's how. 🧵
TLDR point your agent here: https://t.co/9g2jQ2nP4y

[Breg Grockman @alright_mark]

the fly is using the blinkers 😭

[lyra bubbles @_lyraaaa_]

the fly brain can play beat saber

[Wei Wang @IrvingWang18]

@yuntiandeng

[Cell @CellCellPress]

New issue is out👉https://t.co/uP2kI6DjtL

On the cover: the complete connectome of the male adult D. melanogaster central nervous system. The cover depicts a single representative cell from each of the 11,710 neuron types in the dataset, which contains 166,700 neurons in total.

[James Zou @james_y_zou]

Excited that Tabula Sapiens 2 is out at @CellCellPress! >1 million cells mapped across 28 human tissues. All this data is open!

[Wei Wang @IrvingWang18]

Thats wild

[ashe @ashebytes]

since you guys loved the exploding tesla..

I used GPT-6 Astra to create a 3D website that pulls apart the male anatomy into 2,234 modeled pieces!

we are in a renaissance of learning

[Yodai Takei @yodai_takei]

Happy to share the published version of our work on chromatin recording with LagTag! https://t.co/F0oEJ2K984

[Blainey Lab @BlaineyLab]

Out now in @CellCellPress our approach for cellular-self reporting: live-cell transcriptomics with engineered virus-like particles in collab w/ @LindaGGriffith1 lab @MIT @broadinstitute https://t.co/b7KqYYETav

[Hao Wu | 吴昊 @hao_wu_7]

Excited to share spatial NT-seq, now out @NatureNeuro! By distinguishing newly synthesized from pre-existing RNA, this method turns static snapshots of total RNA into spatially resolved views of RNA life cycles. @PennGenetics @PennEpiInst @PennMedCSO
https://t.co/8RFa5Td4GF

[Lingyan Shi @StimulatedRaman]

Our “Little Red Cat”, has finally been formally adopted by Nature Methods!
—UCSD's SRS metabolic imaging + Yale's spatial omics cell typing: one slide that nails identity, location, and metabolism, all while being extendable to transcriptomics, epigenomics, in live cells&tissues

[Feng Yue @yuefeng_1]

Excited to share Spatial-ATAC-Hi-C @naturemethods, spatial profiling of 3D genome organization + chromatin accessibility in tissue. Excitingly, it detects CNVs and SVs in tumors and reveals spatial heterogeneity.

Great collaboration with @RongFan8.

https://t.co/XO0FhoZepO

[Joseph C Wu, MD, PhD @Joseph_C_Wu]

Our review “Induced pluripotent stem cells from discovery to translation” highlighting 20-year history of iPSCs is now published in @NatureMedicine. Congrats to all authors!
@StanfordDeptMed, @StanfordCVI, @UniLeiden, @MSKCancerCenter, @GreenstoneBio
https://t.co/AykIaO5itZ

[Matthias Mann Lab @labs_mann]

Same single cell, two modalities—both at depth. We digest protein first, run Smart-seq3xpress + C18 (Evotip) separation: peptides captured, cDNA in flowthrough. In HeLa & stem cells, proteome tracks cell state; RNA variance flags transitioning cells.
https://t.co/P0EtDp2Tqu

[Jonathan Weissman's Lab @JswLab]

Excited to share our new preprint led by
@YiChenNeumann with incredible collaborators @labs_mann, @BenGewurz, @StephenE92884, and @hopfnerlab
to characterize the function of thousands of viral microproteins from human-infecting viruses! https://t.co/iRXXkWES0N