Iva Guberovic

Postdoc @FrezzaLab || Alumni @HaigisLab @MarcusBuschbeck Lab @MSCActions fellow @ChroMeITN | #AllAboutMetabolism

[Trends in Biochemical Sciences @TrendsBiochem]

Check out these three Reviews touching on diseases:
📝Fumarate-induced succination in kidney cancer (@iva_guberovic @FrezzaLab)
📝Atherosclerosis-induced metabolic reprogramming (@claudiomauro6 @MauroLab_bham @Mic_Certo)
📝JMJD proteins in development and as drug targets

[Peter Georgiev @_petergeorgiev_]

Thrilled to share our study on anti-tumor immunity during aging with @jameshan_sj @alisoneringel @HaigisLab. Here we demonstrate that the loss of tumor-reactive CD8+ T cells is a cardinal feature that accelerates tumor outgrowth in aged mice and promotes resistance to immune checkpoint blockade therapy. Our results suggest that by failing to consider antigen specificity, age-associated dysfunction of CD8+ T cells may be inadvertently conflated with bystander responses within the aged TME and resolve a long standing mystery as to why mice beyond a certain age are recalcitrant to immune checkpoint blockade therapy.

Age-associated contraction of tumor-specific T cells impairs antitumor immunity https://t.co/4naEa8eCd9

[Iva Guberovic @iva_guberovic]

It was a lot of fun diving deep into the world of fumarate-induced succination with @FrezzaLab!
I hope you enjoy the read!

[FrezzaLab @FrezzaLab]

I am very happy to share this article that @iva_guberovic and I wrote about fumarate-driven succination. I hope you find this interesting. We are looking forward to hearing your views.

Functional implications of fumarate-induced cysteine succination https://t.co/kytj3ROclM

[Nature Metabolism @NatMetabolism]

REVIEW | Liron Bar-Peled & Nora Kory (@HarvardChanSPH):

Metabolic compartmentalization can shape organismal #metabolism, while its dysregulation can lead to pathological states.

#TBT

https://t.co/MPRnxLpcTn

[Steve Stegen @SteveStegen]

📢 PhD position available in our #research group 📢
We have an exciting project for a motivated #PhD student to study the impact of gender-affirming therapy on #bone! More info 👇: https://t.co/UQE7m9ybkn
Please share and RT!

@KU_Leuven
@ECTS_science
@AcademyEcts
@ASBMR

[Nature Cell Biology @NatureCellBio]

💫NEW: @MartinWuhr, @brangwynnelab & co use filtration chromatography & quantitative #proteomics of Xenopus egg extracts and show that at least 18% of cytoplasmic proteins are organized in small ~100-nm #BiomolecularCondensates.
👉https://t.co/bAHp8DwHuW
https://t.co/C6r6rpoTlH

[Vamsi Mootha @VamsiMootha]

Delighted to introduce PMF-seq: a new way to link genetic perturbations to detailed bioenergetic phenotypes. We use the method to dissect genetics of mitochondrial ETC branching and acute tBID action. Led by https://t.co/jYQkGEVrpg ⁦@broadinstitute⁩. https://t.co/GT8qUYnLCR

[nature @Nature]

Nature research paper: Decoding chromatin states by proteomic profiling of nucleosome readers https://t.co/vBzZ2ibIJm

[nature @Nature]

Nature research paper: Universal recording of immune cell interactions in vivo https://t.co/XVibs39M3W

[Yihui Shen @DrYihuiShen]

Excited to share my postdoc work out in @nchembio!
We explored the preferences and efficiencies of ATP pathways in cells and tissues. By quantifying metabolic flux and proteomics, we found that respiration makes ATP faster per enzyme mass than glycolysis🧵https://t.co/TVKVHH8Icw

[FrezzaLab @FrezzaLab]

whoa, what a day... a milestone for mitochondrial biology in cancer from the Shackelford lab! https://t.co/1c2n20X4jr

[Ed Chouchani @echouchani]

Our work on the discovery of a biochemical mechanism through which lactate regulates protein function, cell cycle, and proliferation, is out today in @nature.

Congrats to lead authors Weihai, Yun, @luiz_bozi & Patrick! A 🧵

@HarvardCellBio @DanaFarber
https://t.co/Zgsce6IrL6

[Iva Guberovic @iva_guberovic]

Awesome story characterizing how fumarare triggers immune response! Congrats to all, super proud! 🙌🏼

[FrezzaLab @FrezzaLab]

Happy to share the results of our collab with @LabPrudent, led by @vincentZecchin1 and Vincent Paupe @Nature ! We show that Fumarate drives mtDNA release in the cytosol via mitochondrial-derived vesicles (MDVs) to trigger innate immunity! https://t.co/O1zDrA4Ys2

[Marcus Buschbeck and Lab @MarcusBuschbeck]

Please RT.
We are recruiting a postdoc!

We look for someone motivated and sharing our interest in #histone_variants and #leukemia.

More info👇
🌐 https://t.co/oSM8jFg1aW

[Chris Chidley @chidley_chris]

I’m excited to share a new #cancer #metabolism preprint where we explore nutrient transport in cells and tumors in CRISPRi/a screens.
https://t.co/10aNyqUV6E
Our question:
How do small molecules like nutrients and drugs get in and out of cells?
🧵(1/12)

[Mol Syst Biol @MolSystBiol]

Estimation of activity changes for >500 kinases & transcription factors in >1,000 cancer samples & cell lines identifies drivers of signalling dysregulation & patient survival ➡️ https://t.co/4QBxFUMSQv
@pedrobeltrao @IMSB_ETH @saezlab @UniHeidelberg @e_petsalaki @emblebi

[Nature Biotechnology @NatureBiotech]

Chem-map profiles drug binding to chromatin in cells https://t.co/Fp9nJKyZqg

[Nature Metabolism @NatMetabolism]

RESEARCH | Led by Zhaohui Feng (@RutgersU):

The authors identify a non-metabolic mechanism through which LDHA promotes cancer progression. LDHA, independently of its enzymatic activity, directly interacts with & activates Rac1.

https://t.co/LCSxRMC6iI

[Dheva Setiaputra @biochemDheva]

Very excited to share a new preprint from the @durocherlab! We used AlphaFold2 to exhaustively map the 53BP1-RIF1-shieldin-CST pathway and found a novel RIF1-SHLD3 binding interface essential for pathway function. 🧵below 1/6
https://t.co/LKdKE9zayI

[Mike White @genologos]

Out today in @NatureGenet, our group’s single-cell MPRA technology for testing activities of gene regulatory elements in whole tissues.

Congrats to Siqi Zhao and the rest of the crew for their great work!

https://t.co/D5BvafuSQZ