JMB

CAMP4 CEO - Mastering RNA to Control Genes. Ex-Biogen, Ex-Genzyme; Co-founder Vico Therapeutics. Born into science.

[CAMP4 Therapeutics @camp4tx]

We are delighted to enter this collaboration with @BioMarin and leverage the capabilities of our RAP platform to identify druggable regRNA targets. Check out the full release here: https://t.co/kcmshjPVz4

[CAMP4 Therapeutics @camp4tx]

Don’t miss CEO @J_M_Brehm discussing the recently launched clinical study of our candidate for the potential treatment of urea cycle disorders on the First in Human podcast.

🎧Listen at: https://t.co/vroF8zn5Bb #biotech #clinicalresearch @VialTrials

[CAMP4 Therapeutics @camp4tx]

Thanks @AlixVentures for the in-depth interview with CAMP4 CEO @J_M_Brehm!

Hear stories behind our beginnings, scientific discoveries, & everything in between leading to the recent initiation of our Ph1 study of our lead mRNA-amplifying therapeutic. #biotech #RNA

[Jorge Conde @JorgeCondeBio]

Congratulations to @camp4tx on dosing the first participant in their Phase 1 study of CMP-CPS-001, a potential 1st-in-class therapeutic for urea cycle disorders.

It’s a demonstration of the power of platforms — from initial screen to Phase 1 in < 3yrs.

[CAMP4 Therapeutics @camp4tx]

We’re pleased to announce that the first participant has been dosed in the Phase 1 #clinicaltrial of CMP-CPS-001, our first-in-class therapeutic for the potential treatment of #ureacycledisorders (UCDs).

📢 Learn more: https://t.co/H0pVOD5pqL

[JMB @J_M_Brehm]

@AppleHelix Likely, but every entrepreneur should consider the residual value beyond the dollar. Residual value = what is the value beyond that capital, if anything. Some firms add no residual value, or even detract, so neutral is not necessarily bad. Some investors add significant value.

[JMB @J_M_Brehm]

When we look back in time we will realize that series B and series C biotech companies were massively mispriced and it was a once in a decade (venture making career) buying opportunity.

[CAMP4 Therapeutics @camp4tx]

Don’t miss the presentation from Alla Sigova, VP of Biology, at next week’s #RNA Biology and Disease Symposium, hosted by @BostonChildrens' Stem Cell Program (which was launched by CAMP4 founder @leonard_zon !).

Register for this free one-day event: https://t.co/r6KDgw5vN2 https://t.co/D7dFoTeZKG

[JMB @J_M_Brehm]

@patricksmalone https://t.co/CVRi1f2x8x

[CAMP4 Therapeutics @camp4tx]

Today, CAMP4 CFO Kelly Gold joins a Fireside Chat at the @UBS Biotechnology Private Company Virtual Symposium to share our approach of amplifying mRNA, leading to increased production of healthy protein & potentially meaningful therapeutic benefits for hundreds of diseases.

[JMB @J_M_Brehm]

@Jack_O_Meara @kulesatony @aryelipman @snowmaker @ycombinator @LongwoodFund @pillar_vc MTAs can (and have) accomplished this if your goal is to punt on heavy negotiation and contracting. Many times they will have some basic terms to set the stage, if that’s what both parties think is logical.

[JMB @J_M_Brehm]

@matthewherper @JMaraganore This is of course a thought exercise, not a criticism. It's a great, thoughtful piece you wrote. You could easily say we don't have your viewpoint as journalists. My point was saying until any of us are in the role it's hard to know all the reasons decisions are made. That's all.

[JMB @J_M_Brehm]

@Angiejyou @angelosgeo @luba_greenwood Amen.

[Molecular Cell @MolecularCell]

Transcription factors interact with RNA to regulate genes https://t.co/vYlB2L9tiS

[JMB @J_M_Brehm]

Congrats to @camp4tx and @FulcrumTx on their collaboration to advance new therapeutics for Diamond-Blackfan Anemia. We are proud to see Fulcrum taking the lead to bring a new drug to patients in need. Well done @golden_atl!
https://t.co/zBuPdRBDHk

[JMB @J_M_Brehm]

@Biotech2k1 CAMP4 has done this in a comprehensive manner, in primary human cells when available, across 7 different cell types (liver, cns, heart, muscle). A LOT of cross talk with and between signaling pathways makes logic circuits more complicated. Beware of ppl doing this in cell lines.

[Jonathan Henninger @jehenninger]

Delighted that our study on transcription factors binding #RNA is now out in @MolecularCell! We provide evidence that TF-RNA binding is pervasive, important for gene control, development, and disease.

Free paper access here for a limited time! https://t.co/LNNce2YAHO

A 🧵:

[JMB @J_M_Brehm]

This week, in a new research paper, @youngricka, one of @camp4tx founders and a brilliant scientist, upended decades-old dogma about transcription factors and human gene regulation. Read my take and why it's a major breakthrough for tx's. https://t.co/jjvFirvyg5

[Jungsu Kim @jungsukim77]

😲 Time to revise textbooks 🤔
Title: "Transcription factors interact with RNA to regulate genes"

"at least half of TFs also bind RNA, doing so through a previously unrecognized domain"
https://t.co/Tql32vXfct