Jacob R Anderson, M.D. Ph.D.

Interested in structural basis of biologic mechanisms

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

How does VWF form a molecular rope to tether platelets to basement membrane? We elucidate part of the mechanism in our study now online @BloodJournal

https://t.co/JqbCsgueQ9

@alanbrownhms @TimSpringerLab @Jing21346461

1/6

[Marie Hollenhorst, MD, PhD @HollenhorstM]

Thanks for highlighting our commentary on this interesting study! @jacobranderso

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@AnnabelZWang Really awesome work and neat idea looking at physician-patients! Congratulations!

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

Neat back-to-back papers on nodal cilia role in left-right asymmetry. Crazy experiment shows optically trapping a *single-cilium* and wiggling it can determine the organisms final heart position depending on the wiggle side.

https://t.co/fLguDEJtoZ
https://t.co/7HWLG7w0bG

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@conesamingo @AlisterBurt @scipion_em Amazing! Thanks for the link and the heavy lifting. Ill definitely give it a go. Looks like it would be much more convenient than plotting the x/y coordinates on a single Z slice!

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@bj_charles @NatureComms @LuptonCJ @ClaudiaSpahn3 @MonashUni @MonashBDI Congrats! Really neat biology!

[Thorsten Wagner @pixelbaumarkt]

TomoTwin official release pt 1 🥳! After some code streamlining and writing documentation we’ve released the first stable build of TomoTwin. Here’s an example of TomoTwin picking Tc toxins based on a single reference without having to be trained on the protein beforehand. 🧵1/6

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@cryo2go Oh most definitely. Reddit has not been kind to my "How to build a 4x3090 machine" inquiries.

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@cryo2go Totally wicked. In the words of Darth Sidious: “Unlimited Power”. Awesome build. And helpful to have idea of specs for future DIY.

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@cryo2go Is it 2x1600w PSUs? Did you need to install a >30 A breaker?

[Sven Klumpe @svenklumpe]

Interested in pFIB-SEM? Check out this paper by Maud Dumoux, @mcgrange et al. : https://t.co/Wq99tcjmX4 . Happy I could help out with some SerialFIB scripting! Want high contrast and quality images in cryo-FIB-SEM tomography? Imaging at 90 degrees helps! #vEM #FIBSEM #PFIB.

[Blood Journals Portfolio @BloodPortfolio]

Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange https://t.co/Xgq0iha8bN

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

Honored our work contributing to understanding VWF concatamer formation is featured on the latest cover of @BloodJournal !

[Blood Journals Portfolio @BloodPortfolio]

The newest issue of Blood is now available featuring 2022 recommendations from an international expert panel on behalf of the ELN for the diagnosis and management of #AML in adults https://t.co/UiDeuNKGXx

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@cryo2go @benjaminbarad @Supermicro_SMCI Nice. Looks wicked. Should be a fun build !

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@tix2tottenham @HotspurTickets Leicester. Followed

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

@cryo2go @benjaminbarad What mobo will you use and with which 4xgpus? I always felt most mobos couldn't fit 4 3090s.

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

It was great fun to work on such an important molecule. And a fun project to work on with @Jing21346461

6/6

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

How does VWF form a molecular rope to tether platelets to basement membrane? We elucidate part of the mechanism in our study now online @BloodJournal

https://t.co/JqbCsgueQ9

@alanbrownhms @TimSpringerLab @Jing21346461

1/6

[Jacob R Anderson, M.D. Ph.D. @jacobranderso]

Serendipitously, we found VWFs A1 domain is a component of the VWF tubule wall! The A1 domain has important functions in VWF biology, and we were surprised to find it linking helical repeats in the VWF tubule.

5/6