Jan Böhning

Postdoc @MRC_LMB

[Jan Böhning @janboeh]

Great to have this out. Many thanks to my wonderful colleagues and collaborators!

[Reika Watanabe @ReikaWatanabe2]

Our in-situ structural analysis of the Ebola virus nucleocapsid is now published in @CellCellPress! Using cryo-FIB-ET, we revealed a 9Å structure, identifying novel layers and conserved interfaces that may serve as antiviral targets. #Ebola #Virology #StructuralBiology

[Jan Böhning @janboeh]

Great to see this finally out. Many thanks to all involved!

[Carter Lab @Carter_Lab]

Happy to share our new preprint: We imaged protrusions of Drosophila cells with cryoET and found filaments in the microtubule lumen. Subtomo-avg and RNAi suggest these are cofilin-bound actin (cofilactin). By @CamillaVenturaS in collab with Stephen Rogers.
https://t.co/0RFaY19Dph

[cryoEM Papers @cryoEM_Papers]

Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules https://t.co/A1vO8mQ6o5

[Cara Ellison @CaraEllison8]

So excited to share latest work from @Elliott_Lab_Ox! We find BIRC6, an enormous #ubiquitin IAP ligase, directly inhibits caspases and we show how this is blocked by SMAC. https://t.co/xSGWSKk1uh Plus great mass spec collab with @adanpinto @kesslerlabox

[Svetlana Dodonova @Sveta_Dodonova]

Check out our latest story! 🧬❄️🔬
https://t.co/4sJjI8NTUo
The structural connection between the linear nucleosome spacing, 3D tetranucleosome arrangement and linker histone occupancy! @mdombro_ @Sveta_Dodonova @c_dienemann @CramerLab

[Jan Böhning @janboeh]

@nuno_5M @TBharat_lab @lab_chai @ProfSyK @ConradoPedebos @danielabbas99 Thanks! Indeed, we don’t think these are TasA, but rather a contaminant that becomes more pronounced due to the absence of TasA fibres. We sometimes see this contaminant in small amounts in wildtype samples as well.

[Jan Böhning @janboeh]

Glad that I was able to contribute some EM to this exciting proof of concept: proteins can be softly deposited on grids using preparative MS and imaged in cryo. Interestingly, grids can be plunged into liquid N2 since they are not covered by a water film! Congrats to Tim and team

[Jan Böhning @janboeh]

@TheVillaLab @ucsdbiosciences Congratulations Elizabeth! About time they give you tenure - well-deserved! ☺️

[Andres Leschziner @aleschziner]

Our paper with @SamReckPeterson, @TheVillaLab and Stefan Knapp on #LRRK2 and #parkinson is out! Thanks to @MichaelJFoxOrg for their support. Congrats to @ColinDeniston, @JSalogiannis, @ChasingKinases and the rest of the team! #cryoEM

https://t.co/M9r6oHvvvT

[cryoEM Papers @cryoEM_Papers]

The In Situ Structure of Parkinson’s Disease-Linked LRRK2 https://t.co/DgCppPFmWZ