Jason Prini 🔶

Web technologist, designer, developer; learning systems & interactive content. AI tools aficionado. Digital 2D/3D/VR artist

[Jason Prini 🔶 @jasonprini]

“You are the average of the five people you spend the most time with.” - Jim Rohn

The Internet is the permissionless opportunity to be the average of five great people.

[Jason Prini 🔶 @jasonprini]

@hieudinh_ Apple Pencil support: yes

Otherwise: no

[Jason Prini 🔶 @jasonprini]

@Outdoctrination 2 kiwis contains <200mg vitamin C. This is a lot to you? Maybe to someone deeply Vitamin C deficient. But not to anyone eating even a half decent diet.

[Jason Prini 🔶 @jasonprini]

@NateLytea @isabellasg3 That’s how they work, by lowering food drive, causing a sustained caloric deficit. All doctors prescribe resistive training exercise together with glp-1s to reduce lean body mass loss, which happens in any caloric deficit if you don’t work out.

[Jason Prini 🔶 @jasonprini]

@Smadan3k @TheJerzWay This leaves out CPP & EI, as the OP mentioned.

[Jason Prini 🔶 @jasonprini]

@mrrasmulan @grok Maybe if the "boat" is made of solid lead or tungsten?

[Jason Prini 🔶 @jasonprini]

@uberarchangel @ryanhallyall not how any of that works.

[Jason Prini 🔶 @jasonprini]

"The breakdown of aspartame occurs in the gastrointestinal tract by esterases and peptidases, and none of the intact, unhydrolyzed aspartame reaches the bloodstream. Only the digestion products, ie, methanol (≈10% weight of aspartame) and the 2 amino acids phenylalanine (≈50%) and aspartic acid (≈40%), reach the circulation, and they are in the same form as when absorbed into the body from natural food sources such as fruits, vegetables, and protein foods such as meat, fish, eggs, dairy, or legumes."

https://t.co/z6lQ9R80Uc

[Jason Prini 🔶 @jasonprini]

@agingroy Compared to what right? Like how if you stop exercising it stops working? :P

[Jason Prini 🔶 @jasonprini]

@RedPill1991 @MonitoringBias @nypost https://t.co/wg4Vhgrhwn

[Jason Prini 🔶 @jasonprini]

Studies show faster weight loss is associated with reduced incidence of gaining the weight back over multiple years. Every single person I've talked to who's doctor prescribed them GLP1 also said they were prescribed weight training and told to prioritize adequate protein intake. What is "tissue waste"?

[Jason Prini 🔶 @jasonprini]

@RedPill1991 @MonitoringBias @nypost Right, if you hard-diet without protein or training you'll also shed lean-mass = it's not the GLP1s, just as the research I cited shows. Ozempic's primary function is to reduce food drive, helping the user maintain a caloric deficit which is how one loses weight.

[Jason Prini 🔶 @jasonprini]

Of course. Although we have studies that have shown if you maintain adequate protein intake, muscle loss during a sustained caloric deficit can be minimal even without resistive training. With minimal training you can pretty much stop any muscle loss regardless how you maintain a deficit, GLP-1 or not.

Regeneron is studying combing GLP-1s with a myostatin inhibitor (trevogrumab) and anti-activin A (garetosmab) to further mitigate lean mass loss during weight-loss.

[Jason Prini 🔶 @jasonprini]

The studies I cited all show experimental data of no significant muscle loss caused by GLP-1 use. Your links are weight-loss advertisements.

*All diets* that result in significant weight loss will come with lean mass reductions. The studies I cited were able to show data there there was no additional lean mass loss caused by GLP-1s.

[Jason Prini 🔶 @jasonprini]

The muscle loss claim has been debunked.

Sources:
Langer HT, Gilmore NK, Hayden CMT, et al. Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans. Cell Rep Med. 2026;7(3):102665. doi:10.1016/j.xcrm.2026.102665

Look M, Dunn JP, Kushner RF, et al. Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275

Karasawa T, Choi RH, Meza CA, Rout S, Drummond MJ, Chaix A, Funai K. Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Cell Metab. 2025;37(8):1619-1620. doi:10.1016/j.cmet.2025.07.004.

Linge J, Birkenfeld AL, Neeland IJ. Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss?. Circulation. 2024;150(16):1288-1298. doi:10.1161/CIRCULATIONAHA.124.067676

[Jason Prini 🔶 @jasonprini]

@Paragramf0rm @HarmonicLodge @sadreturns The circadian rhythm effect is wildly overblown. The research says blue light causes "statistically significant" change to CR but the experimental data shows it's something like a few minutes a day - which is really no big deal in reality. Hate that flicker though!

[Nathan Clark @nathanclark_]

it’s in gemini, just create it in ai studio. oh, that’s for your personal google one account. for workspace you need gemini business. no, not gemini advanced, that’s ai pro now. unless you need ai ultra. oh agents? you do that in spark actually. no, not gemini api managed agents, that’s different. for coding use jules. unless you mean the agentic ide, that’s antigravity. no, that’s the old antigravity, download the new one. actually gemini cli is being deprecated, use antigravity cli. no the flash model is smarter than the pro model. unless you need pro. if it’s video, use flow. no, flow uses veo. no, nano banana is images. actually that’s in gemini now. unless you’re in search, then it’s ai mode. no, research is notebooklm. anyway it’s all very simple.

[Jason Prini 🔶 @jasonprini]

@KitchenRecipes_ so close - replace bland tomato slice with ketchup/bbq sauce and🤌

[Jason Prini 🔶 @jasonprini]

@taiyasaki @theworldlabs How many people can even run this open source framework themselves compared to how many will pay a few hundred bucks a year to use Marble? Won't @theworldlabs be able to improve from what they can learn from Lyra 2.0? Even just a single 5090 still costs $5000+CAD today on newegg.

[Jason Prini 🔶 @jasonprini]

UVB light is required to stimulate skin to produce Vitamin D, and these lights require eye protection to be worn while in use. SAD lamps do not emit UVB and so do not stimulate Vitamin D. Also, window glass blocks nearly 100% of UVB from sunlight, so you do not get Vitamin D stimulation through natural windows.

If you can't get outside regularly for decent sunlight, just take Vitamin D supplements. They're cheaper than dirt.

[Jason Prini 🔶 @jasonprini]

Alien invasion