Joe Chambers

Researcher @TheCIMR @Cambridge_Uni @MarciniakLab interested in cell biology, especially proteostasis and the ER. More active @joechambers.bsky.social

[Joe Chambers @je_chambers]

Our paper is now out in @ScienceAdvances !

https://t.co/mX05lMhSR7

We found that the disease-causing “Z” mutant of α1-antitrypsin “gums-up” the endoplasmic reticulum (ER) by forming a solid matrix, shown here by hypotonic shock… 1/8

[@drsimoncook.bsky.social @DrSimonCook1]

I have a BBSRC CTP PhD on protein kinases & cancer therapies available to start in Oct 2025. It is a collaboration between my lab @BabrahamInst and @CR_Horizons @BabrahamUK We're a friendly bunch. We like cake. What's not to like? Please RT
https://t.co/i7sG6gA5DL

[Avezov lab @AvezovL]

Our new paper is out, https://t.co/gsfDCeZHHX📄 on how a membrane-curving protein RTN4/Nogo links neurite regeneration and the tubular ER🕸️🧠

It's all about how it narrows tubules, slows luminal transport, restricting Ca2+ supply for the outgrowth puffs ☁️🧑‍🤝‍🧑@koslovergroup
🧵

[Avezov lab @AvezovL]

🚨With @AbellJonny & @Kosloverlab we are excited to organise  “The Endoplasmic Reticulum Structure and Function Across Cell Types” session at #cellbio2024 #ASCBEMBO!

If you are interested in ER, its cellular functions, send us your abstracts by Aug 6🔬

https://t.co/6eq3cyGlVZ

[Joe Chambers @je_chambers]

@dgershlick @EdenJess @TheCIMR @CellBiol_MRCLMB @JLS_Lab Congrats guys. Great stuff!

[Joe Chambers @je_chambers]

@Janin865 @Cambridge_Uni Great to see this out! Congrats!

[Joe Chambers @je_chambers]

@marke_kub @maxplanckpress @GuckLab @MPI_Light Amazing news! Congrats!

[Joe Chambers @je_chambers]

Brilliant news! Congratulations Marina!

[Kuimova Group @KuimovaGroup]

Congratulations to Marina for being awarded the Corday-Morgan #RSCPrizes for the development of unique probes and methodologies in fluorescence imaging! 🎉🔬

[Joe Chambers @je_chambers]

@KuimovaGroup Huge congratulations Marina!

[Alexandra Davies @Alex_Doune]

Only two days left to apply to join my new lab at the University of Manchester @MCF_UoM @FBMH_UoM!

#PleaseShare #Applynow

[Hayley Sharpe @Sharpe_Lab]

We're starting to recruit postdocs to work on this exciting ERC (now UKRI) project. Please get in touch if you would like to join us, or spread the word. #phosphatases #redox #Tcells @SFRR_Europe @ListerInstitute @EMBO_YIP

[Joe Chambers @je_chambers]

@chrisgrbbn @Nature @VallierLab Amazing stuff. Congrats Chris!

[Joe Chambers @je_chambers]

@Prof_Marciniak @bedoctored Goose fair is my mushy pea and mint sauce happy place

[Joe Chambers @je_chambers]

Fantastic opportunity to work with a brilliant scientist using really innovative approaches. Apply!

[Camilla Godlee @CamillaGodlee]

I am hiring a research assistant for my lab working on host-pathogen interactions of bacterial infections.

Please send to anyone who might be interested.

https://t.co/yyTQSd6QqK

[Evan Reid @ReidLab_HSP]

If you're interested in ER morphology and lysosome function in neurons then check our new BioRxiv paper out:
Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons https://t.co/8GBAzdzNLS

[Daniel Fazakerley @DPhaz]

Delighted our paper on oxygen tension in cell culture is now out in @embojournal. Particular congratulations to @joycelyntsi (see her🧵here). Thank you to our many
collaborators, and to funders @wellcometrust @The_MRC @TheBHF
👇
https://t.co/mBTcGhwmYm

[Joe Chambers @je_chambers]

@MCF_UoM @Alex_Doune @acmedsci @FBMH_UoM Congrats Alex! Great news!

[Avezov lab @AvezovL]

Our📰 in PNAS now on how the ER shaped as nanoscopic pipework powers Ca2+ firing

Explains why ER is shaped as a tubular network🕸️🔬and how ER defects cause neurodegeneration🧠?

It’s all about Ca2+

Led by @CecileCrapart 👭👬@koslovergroup @AvezovL

https://t.co/mbM153ULCe
1/4

[Avezov lab @AvezovL]

Luminal transport through intact endoplasmic reticulum limits the magnitude of localized Ca2+ signals | now our in PNAS https://t.co/mbM153ULCe

Additions include analysis of what happens to Ca2+ releases from sheets

and ER misshaping effects on the Ca2+ releasing ip3 receptor

[Joe Chambers @je_chambers]

Come and work with an amazing scientist on amazing questions at the amazing @TheCIMR. It's a no-brainer! Apply!

[Jonny Nixon-Abell @AbellJonny]

🚨 JOB CALL!!! 🚨

If you’re interested in neuronal cell biology, come and work with us to use custom imaging and omics tools to study organelle contact sites in neurons.

Please RT friends‼️

Open calls for a @wellcometrust funded Post doc and RA position listed below…