Structure of the human SAGA coactivator complex is out today at @NatureSMB! - we determined the architecture and structure of hSAGA and comp. non-conserved features with ySAGA revealing dramatic rearrangements and insights on the splicing mod and disease https://t.co/dQldZucYFI
Check out our paper identifying a role for Tra1 (an essential component of two transcriptional co-activator complexes, SAGA and NuA4) in antifungal resistance! Now published in @GeneticsGSA ๐@patounet80@ShapiroRebecca@brandl_lab
Congrats @lab_hat and the many people involved on these two cool NuA4/TIP60 oncogenic fusion stories out this week!
https://t.co/Slk8tYPyvj
https://t.co/9WvOOhPlmy
Quite striking that mislocalization of NuA4/TIP60 activities, not PRC2, seems the dominant oncogenic mechanism, confirmed in patient samples. Also local inhibition of PRC2 activity by txn-linked H3K36me3 is striking.
Today, predoc Jelly Soffers in the Workman Lab defended her thesis titled "A characterization of the composition and gene-regulatory functions of SAGA-related complexes during Drosophila development".
Just spent 2 days at @ScienceStowers on the mock search committee for their job market bootcamp for PDs along w/ the awesome @McKnightLab_UO@elliehoopla@eldavies03
We (constructively) ripped apart practice job talks & chalk talks...
Well Research Gate is good for something. lol
Way to go, Jerry!
With 98 new reads, your contributions were the most read contributions from your institution
Achieved on Dec 30, 2018