Jackson Cahn

Student of evolution and explorer of enzymes. Biocatalysis, biosynthesis, genome mining, crystallography, science memes. SEA-ALW-LAX-ZRH-EWR. Him.

[Jackson Cahn @jkbcahn]

@giveashitnature @TimWannier An excuse to post the best scientific article title of all time.

[Matt Herdman @MattHerdman]

Happy Pride month to the whole LGBTQNJ+ rainbow!

[Jackson Cahn @jkbcahn]

@LinkofSunshine Strong Christine O'Donnell vibes for those who remember.

[Jackson Cahn @jkbcahn]

@owl_posting With apologies to Jean-Luc Picard:

It is possible to commit no mistakes and still lose. That is not a weakness; that is biology.

[Jackson Cahn @jkbcahn]

@BenAetheling @sam_d_1995 On the contrary, you can just walk to where there are more people. The real scary situation is being stuck in a small car alone with a crazy person.

[Jackson Cahn @jkbcahn]

@AndrewDesiderio

[Bo Wang @BoWang87]

People who actually work on using AI to cure cancer and develop new drugs:

[Science Magazine @ScienceMagazine]

Researchers in Science report a kilogram-scale synthesis of enlicitide, a peptide drug for lowering low-density cholesterol that is in a Phase 3 clinical trial.

This new synthesis route leverages engineered enzymes and crystallization of key intermediates, substantially cutting down the number of reaction steps while improving yield. Learn more in a new #SciencePerspective: https://t.co/2g5nUA7d9G

[Állan Ferrari @ajrferrari]

Now available as its peer-reviewed version in Nature:

https://t.co/eV8gyVYJdk

[Hans Renata @hanzyduzit]

https://t.co/PwQdyi02yu

[Jackson Cahn @jkbcahn]

@NIST 🔥🔥🔥

[Jackson Cahn @jkbcahn]

@SocDane The last 40 years have been the most peaceful and prosperous in human history.

[Gina El Nesr @ginaelnesr]

Excited to report the first de novo enzyme catalyzing two of the most energetically demanding reactions in biology—phosphomonoester and phosphodiester hydrolysis—with catalytic efficiencies comparable to natural enzymes! 🚀

desB was designed zero-shot with dEVA. No structure prediction, no pre-defined motif, no reaction-intermediates. 🧵

@StanfordBiosci @bioe_stanford @SLAClab
@EPFL @hes_so @simonduerr

[Jackson Cahn @jkbcahn]

@GallowayLabMIT Congrats Katie!

[Jennifer Listgarten @jlistgarten]

Our review on AI for protein engineering is out now, about this too-fast-moving field full of hype and overclaim, yet one that is having a real impact on the world and can be described in a coherent manner without histrionics
https://t.co/woOWuyTV5R

[Jackson Cahn @jkbcahn]

I think a better analogy is the Wright Flyer. It legitimately achieved a very difficult technical task that humanity had been working towards for a long time, and gave a glimpse at what could be.

[Nikolay Kukushkin @niko_kukushkin]

Citing alphafold as “solving biology” is like citing a paper airplane for solving interstellar travel

[L.-C. Campeau Ph.D. @DrLCsquare]

Just fantastic news for th approval of this fixed dose combination with two compounds very close to my heart! Congrats to all who contributed to this important milestone for patients. #MerckChemistry

https://t.co/Xoib18gdi1

[Jackson Cahn @jkbcahn]

Melanin does not provide electrical energy to cells. Cells do not use electricity, and even if they did melanin has no mechanism to pass electrons to anything. That energy just becomes heat.

The "source" he cites is an online Bitcoin doctor, whatever the hell that means.

[Thomas P Seager, PhD @seagertp]

Every red light device you've ever seen on Twitter uses wavelengths that target the CCO enzyme in mitochondria to stimulate ATP production, and that's a very good thing.

The MyGreen Forest Flashlight does not do this. It is the first LED phototherapy device in the world that targets melanin, instead of CCO.

Why?

Because @AmmousMD told me that melanin absorbs light to provide electrical energy to cells. So I looked for studies that showed what wavelengths would be most effective for energizing melatonin.

They are green (532nm) and near infrared (730nm), which also happen to be the wavelengths of light that dominate the shady forest.

That's right. Forest light is absorbed by melanin in the outer layers of the skin to produce electricity that powers skin cells.

To test the hypothesis that a LED Forest Flashlight might speed healing of cuts and scars on the skin, I treated myself with this new device of my own invention. The results were spectacular.

Inflammation gone. Redness reduced. Skin growing fast under the scab. Accelerated wound repair.

I noticed improvement the day after a single 10 minute treatment and sent pictures to a wound care nurse to verify the rapid rate of healing of cuts on my arm and leg.

So I offered the Forest Flashlight device at a steep discount to readers who would promise to test it for me and write in with their results.

The first review posted this evening and my tester wrote "the results have been incredible" for healing surgical incisions.

[Jackson Cahn @jkbcahn]

@PodSaveAmerica Never Trumpers without exception say "I am putting my own policy preferences aside to urge you to vote for Democrats no matter what until this national crisis is over." That's the opposite of Hasan's approach.

[Jackson Cahn @jkbcahn]

@Duderichy How much did Sora improve lifespan?