josephblayney

PhD gene regulation 🧬🧫 • food, wine, books, films & weightlifting 🍔🍷📖🎞🏋️ • @UniofOxford • VMO

[Stephen Taylor @bioinfbloke]

Our machine learning approach to peak calling "LanceOtron: a deep learning peak caller for genome sequencing experiments" has been published. If you want better peak calls and less false positives in your ChIP-Seq results, please give it a try! https://t.co/U2hQFztBlS

[Mira Kassouf @MiraKassouf]

#Superenhancers function in an orientation dependent manner,challenging #enhancerbiology paradigm.
@Hele_Fran @josephblayney @MariaC_Su @CazzHarrold @jrmmhughes @DownesDamien @MariekeOudelaar @NatureGenet @Hannah_K_Long @jojdavies @generegulation @MRC_WIMM
https://t.co/Dtd8ZLW3VY

[Rob Beagrie @RobBeagrie]

Only one week left to apply for our postdoc position! If you're interested in human genetics, chromatin, and gene regulation then check it out! Informal inquiries always welcome

[Jef Boeke @JefBoeke]

Have you ever made backwards DNA??? Brendan did - on purpose!! . Check out what happens to "vanilla" DNA in yeast and mouse cells. What do they do with DNA they've never seen before? #darkmatterproject strikes again ... courtesy of @bcamellato https://t.co/OBwCh6utfq

[josephblayney @josephblayney]

Massive thanks to @Hele_Fran @JefBoeke , @MRC_WIMM and @MiraKassouf for her amazing supervision!

[josephblayney @josephblayney]

Very excited to share our new pre-print!: Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression https://t.co/01PPmH9GXM ...short thread below (1/6)

[josephblayney @josephblayney]

Lastly, facilitators show functional hierarchy, although this is encoded in their relative positioning rather than their sequences. (6/6)

[Rob Beagrie @RobBeagrie]

🚨Job Alert🚨 We’re hiring a postdoc to work on genetic diseases of chromatin! 🧬

🏫Come work with us at @HumanGeneticsOx in the beautiful @UniofOxford

🗓Closing 6 July

📨 More details at https://t.co/TRLXH3zl7q

Pls share and RT!

#PostdocJobs #GeneticsJobs #genomics #cohesin

[Mira Kassouf @MiraKassouf]

Kicking off 2022 with my first senior #author research paper.The novelty lies in reimagining the use of a well-established #mESC #invitro system harnessing new technologies to serve genetic studies @Hele_Fran @RobBeagrie @DM_Jeziorska @MRC_WIMM @PLOSONE

https://t.co/oBWshTDdFf

[Ed Tunnacliffe @ed_tunna]

Really happy to see our latest work out on bioRxiv. We used live-cell antibody staining to facilitate the study of alpha-globin transcriptional bursting dynamics throughout erythropoiesis and identified changes in transcriptional noise during differentiation. Check it out! ⬇️⬇️⬇️

[James Davies @jojdavies]

Delighted to share my lab’s @jdavieslab first big paper in @Nature!

We’ve developed a new 3C technique called Micro Capture-C that can generate base pair resolution 3C data https://t.co/Mgr26d2bTE

[@AxelVisel.bsky.social @AxelVisel]

Why are ultraconserved enhancer sequences ultraconserved?

Our latest attempt to solve the mystery, led by @Pribaikalochka

Here is the TL;DR thread (1/n)

https://t.co/27AsCzOD0z

[Patrick Cramer @mpgpresident]

Enhancers may cooperate synergistically to determine cell fate. Synergistic enhancers are defined by eRNA synthesis, depend on cell-specific TFs and differ form occupancy-defined superenhancers. Great collaboration with Graf & Söding labs.
Finally out: https://t.co/en8ctYctzz

[Hughes Group @FoldingGenome]

Out Today! Using our new method (scaRNA-seq) we found enhancers regulate PolII Recruitment and Initiation – rather than Pausing
@MolecularCell @generegulation

#GeneRegulation

https://t.co/5EdBrKaEkk

[Marieke Oudelaar @MariekeOudelaar]

I’m very happy to share this @NatureRevGenet review in which Doug Higgs and I discuss the most recent insights into genome organisation, gene regulation and their relationship: https://t.co/H19OMV8qyv #3Dgenome #generegulation

[Marieke Oudelaar @MariekeOudelaar]

Many insights into gene regulation result from in-depth characterisation of model gene loci. We reviewed recent studies of the alpha-globin cluster and lesson learned about gene regulation & genome organisation: https://t.co/KT1ZNViufn, with @RobBeagrie, @MiraKassouf & Doug Higgs