James Holder

Husband, father and post-doc at Uni of Oxford interested in the impact and regulation of PTMs throughout the cell cycle.

[James Holder @JRHCellCycle]

Very proud to share the new paper from myself (Gergely lab) and Jennifer Miles (@baylisslab) #cellcycle #mitosis #centrosome #kinase

Lots of exciting discoveries within!

https://t.co/19xGmGe7Cc

[Spidr Idp @SPIDR_IDP]

Just out @ChemicalScience - the latest SPiDR publication features TACC3 peptidomimetics - these allosterically displace N-Myc and activate Aurora-A.
https://t.co/9tSCQV7uC6

[The EMBO Journal @embojournal]

Cover & highlight #22 by @osman_lab
N&V on senescence/p21 & the path to fibrosis
Commentary on PIWI & RNAs
and…
CEP192 localises mitotic Aurora-A activity
DELE1 maintains muscle proteostasis
Carboxy-terminal polyglutamylation regulates Dishevelled LLPS
…
https://t.co/MRguhXAFSg

[James Holder @JRHCellCycle]

@RobKlose @VdangioE3lab @HVodermaier Thanks Rob! Very happy it’s out.

[James Holder @JRHCellCycle]

Thank you very much to our editor @HVodermaier for expertly guiding us through the peer review process! And to the reviewers for their comments which really helped us reach the finished product.

[The EMBO Journal @embojournal]

The structure of the human Aurora-A:CEP192 complex reveals its importance in facilitating Aurora-A autophosphorylation, TPX2 binding, and activity on the mitotic spindle
@JRHCellCycle, Jennifer Miles, Richard Bayliss, @fanni_gergely et al
https://t.co/5jFtKOlRID

[James Holder @JRHCellCycle]

Many thanks to the @SPIDR_IDP team and the rest of our collaborators for the help and support on this project.

[James Holder @JRHCellCycle]

Very proud to share the new paper from myself (Gergely lab) and Jennifer Miles (@baylisslab) #cellcycle #mitosis #centrosome #kinase

Lots of exciting discoveries within!

https://t.co/19xGmGe7Cc

[James Holder @JRHCellCycle]

CEP192 uses an extensive bi-modal interaction with AurA to produce this signal, which is then protected by TPX2.

Therefore AurA:CEP192 ensures the correct amount of AurA activity in a cell, maintaining genome stability through error-free mitosis.

[James Holder @JRHCellCycle]

@tomogolgier I feel a very strong desire to continually refresh the page!

[James Holder @JRHCellCycle]

@SPIDR_IDP have organized an intrinsic protein disorder conference, June 10th in Leeds. Lots of opportunities for talks and poster. Keynotes by Prof Tompa and Dr Schade. For more information and to submit your abstracts (by 12th April) use the link below.
https://t.co/8Yt4adnOQt

[James Holder @JRHCellCycle]

Still time to register for Wednesday’s virtual conference. Excited to share some of my work with the community!

[Robertus de Bruin @DeRobertus]

6 breakout talks added!!

Virtual Cell Cycle Club meeting: Wednesday March 13

3 Selected talks: Gergely, Mittnacht & @KabecheLab
6 talks in the Breakout Session
1 Keynote:@JanSkotheim

Please REGISTER as soon as possible for this FREE event @abcam
https://t.co/5VCr6bFv5Q…
📷

[James Holder @JRHCellCycle]

I'll be presenting an exciting story focussed on spatial control of the mitotic kinase Aurora-A at the next virtual Cell Cycle conference (13th March). Very grateful to the organizers for selecting my abstract for a short talk!

There is still time to register to attend.

[Robertus de Bruin @DeRobertus]

PROGRAMME
Virtual Cell Cycle Club meeting: Wednesday March 13

3 short talks: Gergely, Mittnacht & @KabecheLab
Breakout session talks
Keynote: @JanSkotheim

Breakout slots still available, deadline this Friday!!

To REGISTER or SUMIT abstract @abcam
https://t.co/5VCr6bFv5Q

[James Holder @JRHCellCycle]

@tomogolgier Im going to Roscoff too!

[James Holder @JRHCellCycle]

Come by my poster, B174, at #cellbio2023 to learn about our exciting story surrounding Aurora A kinase. We’re very proud of the work from myself and the fantastic @SPIDR_IDP team!

[James Holder @JRHCellCycle]

@LabMeraldi @ASCBiology @divanova_1 @ElenaDoria8 Brilliant work, thank you very much for taking the time to discuss the poster with me.

[James Holder @JRHCellCycle]

Heading to Boston this weekend for #CellBio2023 . Can’t wait to share my work and meeting lots of wonderful cell biologists! Come find me at poster 1900, 13.45 on Monday to learn about my work on Aurora A at centrosomes.

[Spidr Idp @SPIDR_IDP]

Very pleased to see our @SPIDR_IDP paper on constrained N-Myc peptides out @ChemBioChem from @dawber_robert with @MWrightLab @AJWilsonGroup and @baylisslab
https://t.co/s8M4WSOyZT

[James Holder @JRHCellCycle]

@PinesLab Thank you for the fantastic talk today at @Dunn_School . Fascinating story surrounding the spatial control of APC/C activity- congratulations to all those involved. Also great to hear a personal perspective on the earlier stages of your career.

[James Holder @JRHCellCycle]

Happy to have played a part in this great work spearheaded first by @SarahCarden92 and then by @ElisaVitiello . Based on a cool discovery by @dr_takashi_ochi . This really opens the doors to being able to answer some vital questions in centrosome biology.

[Ellyviti @ElisaVitiello]

Interested in studying centrosome composition? Check out CAPture, our 1-step purification method to obtain high-resolution centrosome proteomes from mammalian cells. https://t.co/7YzDyWhoZf

[James Holder @JRHCellCycle]

@dr_takashi_ochi @SarahCarden92 Thanks Takashi!! Big team effort , especially from @ElisaVitiello !