Jason Stein

Associate to the Prof, UNC Neuroscience Center & Dept of Genetics

[Luis de la Torre-Ubieta @LTULab]

New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome.
#brain #singlecell #multiomics #DownSyndrome

https://t.co/Rqzg66QQzd

[Nature Neuroscience @NatureNeuro]

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors

@jsteinlab @NanaMatoba @jmvalone4 @BrandonDLe

https://t.co/M38j3Ymtop

[Nana Matoba @NanaMatoba]

It’s been a long journey🚢, with about 1 & 1/2 year since posting on bioRxiv and of course even longer since the project started, but our paper has finally been published in @NatureNeuro 🌠
Congrats @BrandonDLe @jmvalone4 @jsteinlab and all co-authors !
https://t.co/oRwbKavXlh

[AJHG @AJHGNews]

📢New from @jsteinlab!
📰 #Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis
https://t.co/eljvgrFFvG

[Organoid News @organoidscience]

Dr. Jason Stein's lab (@jsteinlab) at @UNC determined the cross-site reproducibility of human cortical #organoid 🧫 (hCO) differentiation using three independent research groups to assay hCOs in multiple differentiation replicates.

@stemcellreports | https://t.co/hdJTP3RaLh

[ASHG @GeneticsSociety]

The authors of @AJHGNews' latest article identify cell-type-specific genetic regulation of RNA editing and alternative polyadenylation in human neurons and neural progenitor cells. Read the full article here: https://t.co/KcdXoNj6Rt #ASHG @jsteinlab

[Hyejung Won @hyejung_won]

I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. This is in collaboration with @jsteinlab, @srikosuri, @mikelove, @_josedavila, @brad_ruzicka, @AP_Boyle. 🧵 follows.

[Nil Aygun @NilAygun8]

We @jsteinlab are delighted to present our recent preprint investigating the impact of genetic variants on cell-type-specific post-transcriptional regulation in human brain https://t.co/bsZmUyfJeP

[Zoltan Molnar @ZoltanMolnar64]

Neocortical Neurogenesis in Development and Evolution edited by WIELAND B. HUTTNER is out https://t.co/DwsR2DBpX4. Superb resource to learn about cortical progenitors; lineages; specification; migration; patterning; cortical regionalisation; folding; disorders; evolution.

[Rose Glass @MagnesiumLass]

Excited to share a new preprint on the cross-site reproducibility of human cortical organoids co-led with Elisa Waxman & Deborah French at CHOP and Satoshi Yamashita & Kazue Hashimoto-Torii at Children's National and my PI @jsteinlab! https://t.co/Ze6YKqrcWM 1/9

[Jason Stein @jsteinlab]

@njahanshad @JulioVillaln1 @lilOHBM I always wondered what happened to that poster

[Jason Stein @jsteinlab]

@mikelove @natstann @hyejung_won @dphansti @cohenlaboratory probably have some ideas

[JoVE @JoVEJournal]

Learn how Felix Kyere, Ian Curtin, Jason Stein and colleagues of @UNC perform whole-brain single-cell imaging and analysis of mouse brains using MRI, tissue clearing, and light-sheet microscopy.

Watch on JoVE: https://t.co/0dkzIQWXck

@jsteinlab @FelixKyere @curtin_ian

[Nil Aygun @NilAygun8]

Our recent work together with @jsteinlab and @mikelove is published in @GenomeBiology, to understand cell-type specific causal gene regulatory networks via mediation analysis. To access the full article please click
https://t.co/Cui9iivvjB

[Jason Stein @jsteinlab]

@TheHectorFranco Congrats Associate Professor Franco! Let's party! 🥳

[Jason Stein @jsteinlab]

@jameemaemusic That's a pretty cool paper I hear

[Sarah Marzi @sj_marzi]

Super excited to host @BrandonDLe from @jsteinlab next Tuesday at 3pm for the #neurogenomics seminars. Bran will present the lab's excellent recent work linking wnt pathway activation with context specific regulatory QTLs. DM/email for the zoom link

[Jason Stein @jsteinlab]

@RRSharp122 @sean_johnsen I hope this helps explain our lab's goals and also clears up any incorrect perceptions. You are welcome to join our lab meetings or journal clubs to come and learn more about what we do and discuss further.

[Jason Stein @jsteinlab]

@RRSharp122 @sean_johnsen Enrichment of educational attainment GWAS within regulatory elements active in the brain and developing brain, and colocalization of brain e/caQTLs with educational attainment GWAS