Iris Kalka

[Nancy Yacovzada @NancyYaco]

Long-term treatment effect of Direct Oral #AntiCoagulants (#DOACs) in #AtrialFibrillation: real-world evidence for efficacy and safety in retrospective nationwide propensity matched observational study🧵
@segal_eran @YeelaTalmor @H_Rossman
#EHJPharmacotherapy @AgewallStefan
1/n

[Biocodex Microbiota Institute @Microbiota_Inst]

"Systemic #AntibodyResponses against human #microbiota flagellins are overrepresented in #ChronicFatigueSyndrome #patients", a @ScienceAdvances study.

#microbiota #MyalgicEncephalomyelitis #COVID19
@segal_eran @KalkaIris @AdinaBlueBird @WeizmannScience
👇
https://t.co/3LqufjB2DV

[Eric Topol @EricTopol]

The immune system response & gut microbiome have been implicated for both #MECFS and #LongCovid. A new @ScienceAdvances systematic report in people with severe ME/CFS found antibodies vs a specific bacterium antigen https://t.co/8x50AYpZWD
@segal_eran @KalkaIris @WeizmannScience

[Elad Barkan @ebarkan]

Our ALS (Lou Gehrig's disease) paper is out in Nature Neuroscience.
Basically we discovered a new pathway that provides a five-fold protection against ALS.
Congrats to the entire team for years-long of efforts.

[Chen Eitan @Chen_Cep_Eitan]

Out @NatureNeuro!

Very excited to share our #ALS association within the non-coding genome:

“Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS”

https://t.co/UqkeFcNNby

#neurogenetics;#ALSresearch;#MND (1/n)

[Dahlia Neumann (דליה נוימן) @Dahlia_Neumann]

For #NationalScienceDay we were glad to facilitate a meeting between the bright @KalkaIris🇮🇱 and students at Ruparell College🇮🇳
Hope to see some of these young minds studing in Israel in the future👩‍🎓👨‍💻
@DavidsonGifted

[Eran Segal @segal_eran]

Our new work on using nationwide health records to estimate how much of the effectiveness of Metformin (diabetes drug) is heritable (genetic)

Analyzed >80,000 patients, and found that ~13% of the drug response may be genetic

Full paper: https://t.co/nEyocuKI1T

What's cool >>>

[Communications Medicine @CommsMedicine]

💡 NEW RESEARCH! Kalka et al. estimate heritability of response to #metformin in patients with type 2 #diabetes using electronic health records & pedigree data | @KalkaIris @GavrieliAmir @segal_eran @lab_segal

https://t.co/qx3PYjPJt1

[Nancy Yacovzada @NancyYaco]

Check out our work on miRNA-181 as a prognostic #biomarker in #ALS.

https://t.co/4yaXceSspl

[Netta Mendelson @NettaMendelson]

Our paper on clinical lab data and disease trajectories is out today on Nature Medicine. https://t.co/btVimRgRI8 @OmrSch @ramijaschek
@aviezer_l @RanBalicer @LiranShlush

[Ziv Shulman Lab @ZivShulman]

Serum Ab crossreactivity against hu-CoVs was described, but what about other species? With @segal_eran we cloned broadly reactive Ab against hu- and animal-CoVs. Details about the platform and its usage for spillover detection in his Twitt. @SciImmunology https://t.co/Q1S2SayY9m

[Omer Weissbrod @oweissb]

We’re happy to release PolyPred, our new method for trans-ethnic PRS.

First, this is an awesome work with co-1st authors @masakanai @shihuwenbo, A. Price & collab. @genetisaur @PeyrotWouter @amitvkhera @StevenGazi @okada_yukinori H. Finucane

Thread👇
https://t.co/MoOYkzMHKZ

[Nancy Yacovzada @NancyYaco]

Really enjoyed the first day of #MLCB2020.

1. Fascinating to (finally) see applications in biology where DL actually makes a big difference. Not a "buzz word" anymore.
2. Big @zoom conferences can work! gather? less.

Join us tomorrow, with keynote @segal_eran and more.

[David Zeevi @DaveZeevi]

So now that the elections are over, I’d like to tell you about @LiatShenhav and my new paper! I want to share the story behind the paper and the process leading to our discovery. It’s a story about scientific serendipity.
**a thread**
https://t.co/2QwYbX2krx

[Eran Segal @segal_eran]

Our new paper on using >2 million national symptom surveys to devise an algorithm for predicting the probability of an individual to test positive for COVID-19 based on answers to 9 simple questions (age, gender, and symptoms)

https://t.co/jjxp77GtYi

[Eran Segal @segal_eran]

Are some people naturally vaccinated for Covid-19?

Our new study found a cross-immune response between Covid-19 and seasonal coronaviruses that only cause common cold:

Covid-19 exposed have antibodies to both Covid-19 and seasonal coronaviruses

[Iris Kalka @KalkaIris]

I'm thrilled to share our work at @segal_lab with @GavrieliAmir.

We devise a novel approach to estimate the heritable component of response to first-line T2D treatment from a nation-wide population size cohort without the use of genetic tests.

https://t.co/2OXnZPII2s

[Iris Kalka @KalkaIris]

Interesting work looking at ASCVD risk for individuals with normal SBP levels.
I just wished results were disaggregated by sex.
Association of Normal Systolic Blood Pressure Level With Cardiovascular Disease Without Risk Factors https://t.co/dsbDIDxFaD

[Martin Mikl @martinjmikl]

Happy to share that our paper on programmed ribosomal frameshifting (PRF), a regulatory process crucial for replication of many viruses like HIV and coronaviruses, is now out in @NatureComms.
https://t.co/h9a8b2Mkq7
with @segal_eran and @TPilpel 1/9

[Daphna Rothschild @D_Rothschild_]

I am excited to share our work at the @segal_lab with Sigal Leviatan and our collaborators in @daytwohealth.

We analyze a big dataset of ~30,000 IL and ~4,000 US individuals to find robust microbiome-host associations.
Check it out:
https://t.co/o4fe5u7njC