MikeMan🇺🇸

One prediction market whale is a trade. 100 is a signal. 👇👇👇

[MikeMan🇺🇸 @Kaneness]

@KHerriage $88,500

[Cernovich @Cernovich]

So many people need jaw surgery it really is insane make sure your kids are eating solid food and masticating this is an epidemic of bad breathing

[Polymarket @Polymarket]

JUST IN: Eli Lilly says its experimental obesity drug cut sleep apnea severity by 60.6% in a Phase 3 trial.

[Afshine Emrani MD FACC @afshineemrani]

1/5
I'm a cardiologist. I see it every day in clinic. Heart failure. Clogged arteries. Early cognitive decline. Fatty liver progressing toward cirrhosis. Patients on five medications who are still losing ground.All driven by the same metabolic storm. A drug just dropped Phase 3 data that has the entire field paying attention. And this isn't just another weight-loss shot.
Retatrutide.
Eli Lilly's triple agonist.
The data is unlike anything we've seen in cardiometabolic medicine. Let me walk you through exactly why — and what it means for the future of heart disease.

[Real Peptides @realpeptides]

Retatrutide additional phase 3 results are out, and the data keeps getting better:

- 28.3% bodyweight lost on 12mg over 80 weeks (70.3 lbs)
- 30.3% at 104 weeks in higher-BMI patients (85 lbs)
- 65.3% dropped below the obesity BMI threshold
- Knee osteoarthritis pain reduced by up to 75.8% (1 in 8 patients are fully pain-free)
- Obstructive sleep apnea significantly improved
- Major drops in triglycerides (41%), non-HDL cholesterol (24.2%), and blood pressure
- A1C fell up to 2.0% and weight down 16.8% in diabetic patients, in just 40 weeks

For those that are unfamiliar, retatrutide now has Phase 3 data showing it reaches well beyond weight loss.

It directly treats the complications that have historically required entirely separate medications.

This is becoming a new category of medicine, and the data is only getting stronger.

[vittorio @IterIntellectus]

what's new is that they didn't use classic CRISPR cutting, which can cause unintended damage and chromosomal chaos.
they used base editing, which lets you edit single DNA letters far more precisely.

in this study, they altered genes that influence LDL cholesterol and hemoglobin in the blood.

it's going to be amazing

[vittorio @IterIntellectus]

holy shit. it happened

they just edited human embryo DNA.

this is the beginning of the end of genetic diseases.

[Cernovich @Cernovich]

“If this becomes law, anyone in New York State currently younger than 21 will never be legally permitted to purchase cigars or any tobacco product, even once they turn 21 years old (the legal age to purchase tobacco goods in the United States).”

[Coinbase 🛡️ @coinbase]

Pre-IPO perps are coming to Coinbase.

Starting today with SpaceX - now live for eligible users outside the US.

24/7 trading. USDC-settled. No expiry.

[MikeMan🇺🇸 @Kaneness]

Good job

[d1namit @0xd1namit]

Today is exactly 1 year since I wrote my first post about Polymarket

A month before that, I had started my X and was posting about different topics like trading and other projects. Then I remembered Polymarket and decided to write a post about their growth

Right away I saw a lot of activity from the community, for example a comment from @Polysights back when they were just starting their journey

I really liked it, I started deepdiving, reviewing projects, coming up with different strategies and so on

Over time the team noticed me, specifically @shayne_coplan, and we even had a call. Some time later I got onboarded and became one of the first affiliates, maybe even the very first one

Back then I even had the blue Polymarket badge for a couple of days before they created the Polymarket Traders account

I also was helping with social media for around 4 months. It was an incredible experience, so thank you @williamlegate and the rest of the team

Then I pivoted into building @Poly_Helper, and I’m still actively working on it to this day. The results are impressive and for me this is the future full pro version of Polymarket

Thank you to everyone who has been with me on this journey. We keep building and grinding

[Mohamed A. El-Erian @elerianm]

Bloomberg on the latest development in US tariff policies.
#economy #tariffs #markets #trade

[Hedgie @HedgieMarkets]

🦔 About half of the US data centers planned to open in 2026 are expected to be delayed or canceled, according to analysts at Sightline Climate. Of the 12 gigawatts of data center capacity announced for this year, only a third is actually under construction. The problem is not money or ambition but electrical components. Transformers, switchgear, and batteries make up less than 10% of data center construction costs but are impossible to build without. US manufacturing cannot meet demand so builders have been sourcing from China, Canada, Mexico, and South Korea. Transformer delivery times have stretched to as long as five years. US imports of high-power transformers from China jumped from fewer than 1,500 in all of 2022 to more than 8,000 in the first ten months of 2025 alone.

My Take
This is the physical reality underneath the AI infrastructure announcements and it deserves more attention than it gets. Hyperscalers have committed over $650 billion in AI infrastructure spending this year. The Atlantic piece I shared last week laid out how the supply chain for this buildout runs directly through the Middle East and China. This story is the electrical component version of the same problem. The US cannot build the data centers it has announced because it cannot manufacture the parts fast enough, and the parts it can get come primarily from China, the country it is simultaneously trying to decouple from through tariffs.

The numbers get more difficult the further out you look. For data centers planned to open in 2027, only 6.3 gigawatts are under construction against 21.5 gigawatts announced. For 2028 through 2032 the vast majority haven't broken ground. There is a growing gap between what has been promised to investors and what is physically being built, and that gap sits underneath valuations that assume the buildout happens on schedule.

Hedgie🤗

[AoverK @AoverK]

The person with a paid-off car, low housing costs, and useful skills has more leverage and options than their lifestyle suggests.

[MikeMan🇺🇸 @Kaneness]

ouch

[Gwart @GwartyGwart]

Someone should build a version of polymarket where you can bet on something and then you win the bet if that thing happens

[MikeMan🇺🇸 @Kaneness]

This wallet put $18k on the Dodgers
https://t.co/0dz3SQUjE1

[Adam Townsend @adamscrabble]

🎂 Scott Adams and I share a birthday and we use to DM “we did it again” and wishes for a good year.

[InGame @InGameHQ]

Kalshi has filed to offer contracts related to fantasy football for the first time, having self-certified contracts on players’ average draft position.

The contracts use Sleeper’s single-QB point-per-reception redraft leagues as the sole source agency to determine ADP. In February, Sleeper started offering Kalshi’s sports event contracts.

[Real Peptides @realpeptides]

Retatrutide's liver data is unlike anything we've seen from a weight loss drug:

- 86% liver fat reduction at 48 weeks, most of it within the first 24 weeks
- 93% of patients achieved completely normal liver fat levels

For context, tirzepatide reduces liver fat by 45–57%.

One in three adults has fatty liver disease and most don't know it.

The reason for this is retatrutide's glucagon receptor. It tells the liver directly to burn its stored fat, not just reduce calories coming in.

[Silky 2.0 @SilkLifeMedSpa]

Each and every one of us exist for a purpose far more than the job you hold, the career you have or how much money you have in your bank account… The current matrix is so flawed, and does the opposite of recognize humanities brilliance

[MikeMan🇺🇸 @Kaneness]

Having financially illiterate children is not a mark of true spirituality

[Justin Cabral @justincabra1]

@6Steeler @luke_mccown Teaching financial literacy in this way is not contrary to one’s true value in Christ.

In fact, a better understanding of value-for-value actually enriches the meaning of the unmerited grace of God.

Having financially illiterate children is not a mark of high spirituality.

[MikeMan🇺🇸 @Kaneness]

66% prediction market whales are predicting “no” on this one

[Polymarket Sports @PolymarketSport]

A trader just put $1,550,444.00 on Arsenal to win the Champions League at a 47% chance

The payout is $3,250,230.00

This would be the first Champions League title in Arsenal’s history