Oktay I. Kaplan

The Kaplan lab uses C. elegans as a model system to understand the molecular basis of rare diseases & functional inference of genetic variants.

[Oktay I. Kaplan @KaplanOLab]

@alperakay_ @DimitriadiLab Congrats Alper:)

[European Journal of Human Genetics @ejhg_journal]

Cranioectodermal Dysplasia (skeletal, ectodermal, renal & liver defects) is now linked to a non-IFT gene, CILK1.
#Genetics #CED #Ciliopathy #EJHG

https://t.co/5SUUTtGJfV

[Oktay I. Kaplan @KaplanOLab]

Grateful to my PhD student Ferhan Yenisert for pushing the ciliome field forward
#ciliome #ciliagenes #ciliopathy #genomics #bioinformatics #ciliahub #cilia #cilium

[Oktay I. Kaplan @KaplanOLab]

New preprint!

We all know mitochondria & lysosomes depend on thousands of genes. But what about the ciliome?

👉 How many human genes actually build and regulate cilia?

https://t.co/Cbq5IAxG6I

[Oktay I. Kaplan @KaplanOLab]

The result: ~10% of the human genome encodes ciliary genes. This represents a Gold Standard update of known ciliary genes. Read the preprint: https://t.co/Cbq5IAx8ha
Explore the database: https://t.co/Z5DUiJGu55

Code: https://t.co/28OJEICxJX

[European Journal of Human Genetics @ejhg_journal]

A novel genetic cause of Cranioectodermal Dysplasia (CED) in five new cases @Abdulla97690428, @KaplanOLab
This study identifies CILK1, a non-core-IFT protein-encoding gene, as the first of its kind linked to CED.

https://t.co/5SUUTtGbqn

[Molecular Biosystems Conference @molbiosystems]

⏳ Financial Aid Application deadline approaching!

Child/dependent care support (available to all attendees) and fellowships for ECRs are available.

Don't miss your chance to join us for #mbiosys25.

📆Apply by *this Wednesday*, Apr 30!
🌎 Chile awaits — 🧬🧪🗻

[Oktay I. Kaplan @KaplanOLab]

@tohturemmi Tatile çıkmak:)

[Oktay I. Kaplan @KaplanOLab]

@KonacAhsen @yourUMG Tebrikler Ahsen:)

[Emre Yaksi @yaksi_emre]

Taking about diversity, equity and inclusion. So many students miss the opportunities of their life time, through visa rejections, preventing them from attending conferences. Is this the kind of European immigration policy to recruit talents to Europe ? @ItalyinIstanbul ?

[Oktay I. Kaplan @KaplanOLab]

@MahjoubLab @EuroCilia2024 UCD is a stunning location and the perfect venue for organizing the #Cilia2024 meeting.

[Oktay I. Kaplan @KaplanOLab]

@KarenL_PhD I just finished reading the paper. Fantastic work, Karen!

[Oktay I. Kaplan @KaplanOLab]

@VMacarelli Thanks:)

[Oktay I. Kaplan @KaplanOLab]

A couple of months ago, I had to visit the ER due to severe pain. The team acted quickly and saved my life, and I spent 6 days in the ICU

I'm on the road to recovery now, but paper revisions are delayed as part of this necessary healing process
I was away from X during this time

[Elif Nur Firat-Karalar @CytoLabKoc]

We are happy to contribute to a new paper by @KaplanOLab, which generated the Ciliogenics database for predicting novel ciliary genes. @EfeBegar used localization and loss-of-function experiments to validate new ciliary proteins in mammalian cells. @NAR_Open

[Oktay I. Kaplan @KaplanOLab]

@alunellab @NAR_Open Many thanks

[Oktay I. Kaplan @KaplanOLab]

Our paper "CilioGenics: an integrated method and database for predicting novel ciliary genes" is out in @NAR_Open !

https://t.co/h4AQjwJiRi

A preprint of this work was posted in April 2023.

[Oktay I. Kaplan @KaplanOLab]

We are very excited to share the preprint from our lab:

We combined multiple datasets (scRNA-seq, comparative genomics, PPI, transcription factors based regulatory networks) for predicting novel ciliary genes

[Oktay I. Kaplan @KaplanOLab]

We extend our deepest appreciation to the spirit of open and collaborative science.

[Oktay I. Kaplan @KaplanOLab]

In our study, we combined multiple datasets, including single-cell RNA sequencing (scRNA-seq) from various tissues, comparative genomics, protein-protein interactions (PPI), and transcription factor-based regulatory networks.

[Oktay I. Kaplan @KaplanOLab]

We integrated these to provide a CilioGenics score for each human gene, assessing its potential to be a ciliary gene. In the paper, we describe several newly identified ciliary genes, such as WDR54, TMEM145, ZNF474, and ZC2HC1A.